Protein Alignment dmrt93B and DMRTA2

DIOPT Version :10

• Sequence 1: NP_524428.1
• Gene: dmrt93B / 42494
• FlyBaseID: FBgn0038851
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_115486.1
• Gene: DMRTA2 / 63950
• HGNCID: 13908
• Length: 542
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 125/488 - (25%)
• Similarity: 178/488 - (36%)
• Gaps: 195/488 - (39%)

  Fly     2 ASSSGEPADEVAN---------KRPRLVAN------PKATKIVEPTPAKVTNRVPKCARCRNHGI 51
            |:::|.|...||:         ..|..||.      |...:..|..|     |.||||||||||:
Human    19 ATATGPPVASVASVAAAAAAAASLPVSVAGGLLRGPPLLLRAAEKYP-----RTPKCARCRNHGV 78

  Fly    52 ISELRGHKKLCTYKNCKCAKCVLIFERQRIMAAQVALKRQQAVEDAIAMR---LVANKTGRSIDA 113
            :|.|:|||:.|.:|:|.||||.||.||||:|||||||:||||.|:..|..   |.....|.::.|
Human    79 VSALKGHKRYCRWKDCLCAKCTLIAERQRVMAAQVALRRQQAQEENEARELQLLYGTAEGLALAA 143

  Fly   114 ----LPPG---NIFG------------------------------------------LTVTQPSS 129
                :||.   .:||                                          |...:|.|
Human   144 ANGIIPPRPAYEVFGSVCAADGGGPGAGAPAGTGGGAAGAGGSEAKLQKFDLFPKTLLQAGRPGS 208

  Fly   130 P--------------------------------------------RAKRE--------------- 135
            |                                            ||.:|
Human   209 PLPPPVKPLSPDGADSGPGTSSPEVRPGSGSENGDGESFSGSPLARASKEAGGSCPGSAGPGGGG 273

  Fly   136 DDQVEKTISEVEQQHLKQREEEYSESPAVAQDL---SAPRRDNVSQTAIDMLAQLFPQRKRSVLE 197
            ::....:.|.:..:...:.::|..|: |.|..|   |.||:    :|.:|:|.::||..:|.|||
Human   274 EEDSPGSASPLGSESGSEADKEEGEA-APAPGLGGGSGPRQ----RTPLDILTRVFPGHRRGVLE 333

  Fly   198 LVLKRCDLDLIRAIENV---------SPTGKSSPVD--------VTSNQLPSQ------------ 233
            |||:.|..|:::|||.|         :..|.::|.|        ...:..||:
Human   334 LVLQGCGGDVVQAIEQVLNHHRGGLAAGLGPAAPPDKAAVGAAAAADDAWPSRVDAAAAAAAAAG 398

  Fly   234 EPGMLTTMPQP------APPR-----SSAFRPVITDQYQSKSVVE-LKPPV--FGGSASAAAAAA 284
            .||    :|.|      |||.     :.|..|.......|:|... |:|..  ||..|.|....|
Human   399 GPG----LPAPLQAGPAAPPHHRPLLAGAMAPGALGSLSSRSAFSPLQPNASHFGADAGAYPLGA 459

  Fly   285 ICAYPKWFVP--LSFPVTMGH---LSNLAPRCT 312
                |....|  |::.....|   |:.:||..|
Human   460 ----PLGLSPLRLAYSAAAAHSRGLAFMAPYST 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dmrt93B	NP_524428.1	DM	39..85	CDD:459924	31/45 (69%)
		CUE_DMA	176..214	CDD:270553	17/37 (46%)
DMRTA2	NP_115486.1	DM	66..112	CDD:459924	31/45 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..316		16/119 (13%)
		CUE_DMA_DMRTA2	312..353	CDD:270601	19/44 (43%)
		DMRT5_DMB	434..513	CDD:466773	17/59 (29%)