DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmrt93B and dmrt3a

DIOPT Version :9

Sequence 1:	NP_524428.1	Gene:	dmrt93B / 42494	FlyBaseID:	FBgn0038851	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_001005779.2	Gene:	dmrt3a / 450035	ZFINID:	ZDB-GENE-021220-3	Length:	448	Species:	Danio rerio

Alignment Length:	354	Identity:	104/354 - (29%)
Similarity:	146/354 - (41%)	Gaps:	119/354 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PAKVTNRVPKCARCRNHGIISELRGHKKLCTYKNCKCAKCVLIFERQRIMAAQVALKRQQAVEDA 97
            |.....|.||||||||||::|.|:|||:.|.:|:|.|.||:||.||||:|||||||:||||.|.
Zfish    18 PRAPLQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQANES- 81

  Fly    98 IAMRLVANKTGRSIDALPPGNIFGLTVT---QPSSPRAKRED----------------------- 136
                 :.:....|:.|||     |:||:   |.::|||...|
Zfish    82 -----LESLIPESLRALP-----GITVSSGEQSANPRASDIDLRWNTETGTPKTPQDLSDELSGE 136

  Fly   137 ---------DQVEKTISEVEQQH------------LKQREE-------------------EYSES 161
                     |:..:.:|..|:..            ..|.||                   :||..
Zfish   137 QSGGENGGSDREPEAVSSPEESKPNLCCTPDTSDPSPQLEESRFGLSKSCSDPEPKSDNPKYSPE 201

  Fly   162 P-----AVAQDLSAPRRDNVSQTAIDMLAQLFPQRKRSVLELVLKRCDLDLIRAIE-NVSPTGKS 220
            |     .::..:|.|.....::..:::|.::||..|.:||||:||.|..||:.||| .:|.....
Zfish   202 PNLLIEGLSGSVSLPFSLRANRPPLEVLKKIFPAHKPAVLELILKGCGGDLVGAIEILLSSRSTM 266

  Fly   221 SPVDVTSNQ-----LPSQEPGMLTTMPQPAPPRS-------SAFRPVITDQYQSKSVVELKPPVF 273
            .|..:.|..     |||.  |.|...|..:.|.|       ||||...:.::.|:|        .
Zfish   267 KPEKILSESSDALVLPSN--GHLFEHPLSSYPVSSSKWSVGSAFRVPDSLRFSSES--------S 321

  Fly   274 GGSASAAAAAAICAYPKWFVPLSFPVTMG 302
            ||....              |||.|:..|
Zfish   322 GGVVPG--------------PLSMPLQHG 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmrt93B	NP_524428.1	DM	39..85	CDD:279137	30/45 (67%)
dmrt93B	NP_524428.1	CUE_DMA	176..214	CDD:270553	16/38 (42%)
dmrt3a	NP_001005779.2	DM	24..70	CDD:279137	30/45 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..203		14/104 (13%)
		CUE_DMA_DMRTA3	221..263	CDD:270602	17/41 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..448
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D383821at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12322
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3693
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.910