DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmrt93B and Dmrta2

DIOPT Version :9

Sequence 1:	NP_524428.1	Gene:	dmrt93B / 42494	FlyBaseID:	FBgn0038851	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_001101421.2	Gene:	Dmrta2 / 313471	RGDID:	1308173	Length:	536	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	122/485 - (25%)
Similarity:	176/485 - (36%)	Gaps:	194/485 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASSSGEPADEVAN---------KRPRLVAN------PKATKIVEPTPAKVTNRVPKCARCRNHGI 51
            |:::|.|...||:         ..|..||.      |...:..|..|     |.||||||||||:
  Rat    18 ATATGPPVASVASVAAAAAAAASLPVSVAGGLLRAPPLLLRAAEKYP-----RTPKCARCRNHGV 77

  Fly    52 ISELRGHKKLCTYKNCKCAKCVLIFERQRIMAAQVALKRQQAVEDAIAMR---LVANKTGRSIDA 113
            :|.|:|||:.|.:|:|.||||.||.||||:|||||||:||||.|:..|..   |.....|.::.|
  Rat    78 VSALKGHKRYCRWKDCLCAKCTLIAERQRVMAAQVALRRQQAQEENEARELQLLYGTAEGLALAA 142

  Fly   114 ----LPPG---NIFG------------------------------------------LTVTQPSS 129
                :||.   .:||                                          |...:|.|
  Rat   143 ANGIIPPRPAYEVFGSVCATDGGGPGAGAPAGSAGGAGGAGGAEAKLQKFDLFPKTLLQAGRPDS 207

  Fly   130 P--------------------------------------------RAKR---------------- 134
            |                                            ||.:
  Rat   208 PQPPPGKPLSPDGADSGPGTSSPEVRPGSGSENGDGESFSGSPLARASKEAGGSCPGSAGASGGG 272

  Fly   135 EDDQV-------EKTISEVEQQHLKQREEEYSESPAVAQDLSAPRRDNVSQTAIDMLAQLFPQRK 192
            |:|..       .::.||.:::     |.|.:.:|.:... ..||:    :|.:|:|.::||..:
  Rat   273 EEDSPGSSSPLGSESGSEADKE-----EAEAAPTPGLGGG-PGPRQ----RTPLDILTRVFPGHR 327

  Fly   193 RSVLELVLKRCDLDLIRAIENV---------SPTGKSSPVD--------VTSNQLPSQE------ 234
            |.||||||:.|..|:::|||.|         :..|.::|::        ...:..|.:.
  Rat   328 RGVLELVLQGCGGDVVQAIEQVLNHHRGGLAAGLGPAAPLEKAAVSAAAAVEDAWPGRVEAAAAG 392

  Fly   235 ----PGMLTTMPQPAPPR-----SSAFRPVITDQYQSKSVVE-LKPPV--FGGSASAAAAAAICA 287
                |..|.|.| .|||.     :.|..|.......|:|... |:|..  ||..|.|....|
  Rat   393 GAGLPAPLQTGP-AAPPHHRPLLAGAMTPGALGSLSSRSAFSPLQPNASHFGADAGAYPLGA--- 453

  Fly   288 YPKWFVP--LSFPVTMGH---LSNLAPRCT 312
             |....|  |::.....|   |:.:||..|
  Rat   454 -PLGLSPLRLAYSAAAAHSRGLAFMAPYST 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmrt93B	NP_524428.1	DM	39..85	CDD:279137	31/45 (69%)
dmrt93B	NP_524428.1	CUE_DMA	176..214	CDD:270553	17/37 (46%)
Dmrta2	NP_001101421.2	DM	65..111	CDD:395608	31/45 (69%)
Dmrta2	NP_001101421.2	CUE_DMA_DMRTA2	311..352	CDD:270601	19/44 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12322
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X984
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010