DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmrt93B and DMRT2

DIOPT Version :9

Sequence 1:	NP_524428.1	Gene:	dmrt93B / 42494	FlyBaseID:	FBgn0038851	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_001374487.1	Gene:	DMRT2 / 10655	HGNCID:	2935	Length:	561	Species:	Homo sapiens

Alignment Length:	380	Identity:	101/380 - (26%)
Similarity:	147/380 - (38%)	Gaps:	138/380 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RPRLV--ANPKATKIVEP-TPA------KVTNRVPKCARCRNHGIISELRGHKKLCTYKNCKCAK 71
            ||.|.  |:|..|...|. |||      :..:|.||||||||||::|.|:|||:.|.:::|:||.
Human    87 RPPLAPQASPAGTGPRERCTPAGGGAEPRKLSRTPKCARCRNHGVVSCLKGHKRFCRWRDCQCAN 151

  Fly    72 CVLIFERQRIMAAQVALKRQQAVED--------------AIAMR------LVANKTGRSIDALPP 116
            |:|:.||||:|||||||:||||.||              |:..|      |:|.........:|.
Human   152 CLLVVERQRVMAAQVALRRQQATEDKKGLSGKQNNFERKAVYQRQVRAPSLLAKSILEGYRPIPA 216

  Fly   117 GNIFGLT--VTQPSSPRAKRE----DDQVEKTISEVEQQHLKQRE-------------------- 155
            ....|.|  :..|.|.|.::.    |.::|..:.|.|   .|:||
Human   217 ETYVGGTFPLPPPVSDRMRKRRAFADKELENIMLERE---YKEREMLETSQAAALFLPNRMVPGP 278

  Fly   156 ------EEYSESPAVAQDLSAPRRD--NVSQTAIDMLAQL---------------------FPQR 191
                  ..||.||     :..|.:|  |...|.:|:..|.                     :|..
Human   279 DYNSYKSAYSPSP-----VEPPSKDFCNFLPTCLDLTMQYSGSGNMELISSNVSVATTYRQYPLS 338

  Fly   192 KRSVL---------ELVLKRCDLDLIRAIENVSP------------TGKSSPVDVTSNQLPSQEP 235
            .|.::         .|:.::|.|:...:::.:.|            .|.|:..|:    :||:..
Human   339 SRFLVWPKCGPISDTLLYQQCLLNATTSVQALKPGASWDLKGARVQDGLSAEQDM----MPSKLE 399

  Fly   236 GMLTTMPQP-------------APPRSSAFRP--------VITDQYQSKSVVELK 269
            |.|.....|             |.|..|||.|        |.||...::..|..|
Human   400 GSLVLPHTPEIQTTRSDLQGHQAVPERSAFSPPRRNFSPIVDTDSLAAQGHVLTK 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmrt93B	NP_524428.1	DM	39..85	CDD:279137	28/45 (62%)
dmrt93B	NP_524428.1	CUE_DMA	176..214	CDD:270553	8/67 (12%)
DMRT2	NP_001374487.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..119		10/31 (32%)
		DM	119..165	CDD:395608	28/45 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..435		6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D383821at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.780