DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment r-l and URA5

DIOPT Version :9

Sequence 1:	NP_524427.1	Gene:	r-l / 42493	FlyBaseID:	FBgn0003257	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_013601.1	Gene:	URA5 / 854865	SGDID:	S000004574	Length:	226	Species:	Saccharomyces cerevisiae

Alignment Length:	208	Identity:	55/208 - (26%)
Similarity:	98/208 - (47%)	Gaps:	38/208 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EINAFKFGDFKMKVGINSPVYFDLRVIVSYPDVMQTVSDLLVEH---IKDKQLSAKHVCGVPYTA 79
            |..|.:||.||:|.|..||.:|:|.:.    :..:.:|:|...:   |....|....:.|..|..
Yeast    18 ECQALRFGSFKLKSGRESPYFFNLGLF----NTGKLLSNLATAYAIAIIQSDLKFDVIFGPAYKG 78

  Fly    80 LPLATIVSVQ---------QGTPMLVRRKEAKAYGTKKLVEGIFNAGDTCLIVEDVVTSGSSI-- 133
            :|||.||.|:         |.......|||||.:|...::.|........||::||:|:|::|
Yeast    79 IPLAAIVCVKLAEIGGSKFQNIQYAFNRKEAKDHGEGGIIVGSALENKRILIIDDVMTAGTAINE 143

  Fly   134 -LDTVRDLQGEGIVVTDAVVVVDREQ----------GGVANIA-KHGVRMHSLFTLSFLLNTLHE 186
             .:.:.:.:|:   |..:::.:||::          .....:: |:|:.:.|:.:|..::..|.
Yeast   144 AFEIISNAKGQ---VVGSIIALDRQEVVSTDDKEGLSATQTVSKKYGIPVLSIVSLIHIITYLE- 204

  Fly   187 AGRI---EKSTVE 196
             |||   |||.:|
Yeast   205 -GRITAEEKSKIE 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r-l	NP_524427.1	PRTases_typeI	1..202	CDD:294217	55/208 (26%)
r-l	NP_524427.1	OMPdecase	258..479	CDD:278637
URA5	NP_013601.1	pyrE	14..199	CDD:129436	47/187 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0461
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.88686	Normalized mean entropy	S1042
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100519
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1047
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.690