DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment r-l and umps

DIOPT Version :9

Sequence 1:	NP_524427.1	Gene:	r-l / 42493	FlyBaseID:	FBgn0003257	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	XP_031749134.1	Gene:	umps / 496817	XenbaseID:	XB-GENE-5874685	Length:	541	Species:	Xenopus tropicalis

Alignment Length:	496	Identity:	232/496 - (46%)
Similarity:	318/496 - (64%)	Gaps:	30/496 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AQNSDKMRALALKLFEINAFKFGDFKMKVGINSPVYFDLRVIVSYPDVMQTVSDLLVEHIKDKQL 67
            |...:.:|.||.:|:.:.|.|||.|.:|.|..||||||||||||:|.::..|:|:|.:..::..:
Frog    64 AGEREPLRDLAARLYRVQALKFGSFVLKSGAVSPVYFDLRVIVSHPTLLNQVADVLYQTARNGGV 128

  Fly    68 SAKHVCGVPYTALPLATIVSVQQGTPMLVRRKEAKAYGTKKLVEGIFNAGDTCLIVEDVVTSGSS 132
            ....||||||||||:|||:..|...|||:||||||.||||:||||....|:||||:|||||||||
Frog   129 PYTSVCGVPYTALPIATIICSQHQLPMLIRRKEAKDYGTKRLVEGTITPGETCLIIEDVVTSGSS 193

  Fly   133 ILDTVRDLQGEGIVVTDAVVVVDREQGGVANIAKHGVRMHSLFTLSFLLNTLHEAGRIEKSTVEA 197
            :::|...|:.||:||.||:|:|||||||...:|:.|:|:||:|:||.|:..|...|.:...||..
Frog   194 VMETAEVLRREGLVVEDAIVLVDREQGGRERLAQGGIRLHSVFSLSLLMELLRSLGAVGSETVSN 258

  Fly   198 VAKYIAAVQI-----NSDGTFVGGDKGDVVRANDLQRTKLTYENRANL-AKSAVAKRLFNLIASK 256
            |.::|...|:     ..|...|                 :.|..||.. ....||.|||.::|.|
Frog   259 VQRFIQENQVPAPTPTPDPPSV-----------------MEYSRRACAPGVHPVASRLFAIMARK 306

  Fly   257 QTNLCLAADLTHADEILDVADKCGPYICLLKTHVDIVEDFSDKFIADLQALAQRHNFLLMEDRKF 321
            :|||||:||:|.|.|:|.:|.:.||.||:||||:||:.||:.|..::|||||::|.|||.|||||
Frog   307 ETNLCLSADVTDASELLRLAAELGPSICMLKTHIDILGDFTPKVASELQALAEQHQFLLFEDRKF 371

  Fly   322 ADIGNTVSLQYGKGIYKISSWADLVTAHTLPGRSILQGLKAGLGEGGAGKERGVFLLAEMSASGN 386
            |||||||..||..|||:||||||:|.||.:||..::|||:    |.|....||..|:||||:.|:
Frog   372 ADIGNTVRHQYEGGIYRISSWADVVNAHVVPGPGVVQGLR----EVGGPINRGCLLIAEMSSEGS 432

  Fly   387 LIDAKYKENSNKIATEGADVDFVAGVVCQSSDAFAFPGLLQLTPGVKIDEGVDQLGQQYQSPEHV 451
            |....|.:.:.::|.:..  |||.|.: ........|.|:.|||||:|..|.|:|||:||:|..|
Frog   433 LATGDYTKAAVQMAEQHR--DFVIGFI-SGRRVGRDPALVHLTPGVQIQAGGDELGQRYQTPYEV 494

  Fly   452 VKERGADIGVVGRGILKASSPKQAAQTYRDRLWAAYQDRVA 492
            :..:|:|:.:||||||.|::..:.|:.||...|.||...:|
Frog   495 IVNKGSDVIIVGRGILSAANRLEVAEMYRRAGWEAYLSAIA 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r-l	NP_524427.1	PRTases_typeI	1..202	CDD:294217	103/198 (52%)
r-l	NP_524427.1	OMPdecase	258..479	CDD:278637	109/220 (50%)
umps	XP_031749134.1	PRTases_typeI	66..266	CDD:412297	103/199 (52%)
umps	XP_031749134.1	OMPdecase	308..522	CDD:395160	109/220 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	205	1.000	Domainoid score	I2861
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H319
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1758
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1303452at2759
OrthoFinder	1	1.000	-	-		FOG0003431
OrthoInspector	1	1.000	-	-		oto103506
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2793
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060