DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment r-l and ura4

DIOPT Version :9

Sequence 1:	NP_524427.1	Gene:	r-l / 42493	FlyBaseID:	FBgn0003257	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_587705.1	Gene:	ura4 / 2538768	PomBaseID:	SPCC330.05c	Length:	264	Species:	Schizosaccharomyces pombe

Alignment Length:	268	Identity:	120/268 - (44%)
Similarity:	166/268 - (61%)	Gaps:	19/268 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 TYENRANLAKSAVAKRLFNLIASKQTNLCLAADLTHADEILDVADKCGPYICLLKTHVDIVEDFS 297
            :|..||...|:.:||.|..|:..||:||.:|.|||...|||::.||.|||:|::|||:|:||||.
pombe     8 SYSARAEGMKNPIAKELLALMEEKQSNLSVAVDLTKKSEILELVDKIGPYVCVIKTHIDVVEDFD 72

  Fly   298 DKFIADLQALAQRHNFLLMEDRKFADIGNTVSLQYGKGIYKISSWADLVTAHTLPGRSILQGLKA 362
            ...:..|.||.::|.||:.||||||||||||.|||..|:|||:|||.:...||:||..|:||||
pombe    73 QDMVEKLVALGKKHRFLIFEDRKFADIGNTVKLQYASGVYKIASWAHITNCHTVPGEGIIQGLK- 136

  Fly   363 GLGEGGAGKERGVFLLAEMSASGNLIDAKYKENSNKIATEGAD--VDFVAGVVCQSSDAFAFPGL 425
               |.|....||:.||||||:.|:|....|.|.:.:...:..|  ..|:||        ..||.|
pombe   137 ---EVGLPLGRGLLLLAEMSSKGSLATGSYTEKTLEWFEKHTDFCFGFIAG--------RRFPNL 190

  Fly   426 ----LQLTPGVKIDEGVDQLGQQYQSPEHVVKERGADIGVVGRGILKAS-SPKQAAQTYRDRLWA 485
                :.::||:.:|...|.|||||::||.|:...|:||.:||||:..|. :|...|:.||:..|.
pombe   191 QSDYITMSPGIGLDVKGDGLGQQYRTPEEVIVNCGSDIIIVGRGVYGAGRNPVVEAKRYREAGWK 255

  Fly   486 AYQDRVAK 493
            |||.|:::
pombe   256 AYQQRLSQ 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r-l	NP_524427.1	PRTases_typeI	1..202	CDD:294217
r-l	NP_524427.1	OMPdecase	258..479	CDD:278637	103/227 (45%)
ura4	NP_587705.1	OMPdecase	33..249	CDD:278637	103/227 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	191	1.000	Domainoid score	I721
eggNOG	1	0.900	-	-		E1_COG0461
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	222	1.000	Inparanoid score	I899
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003431
OrthoInspector	1	1.000	-	-		oto101120
orthoMCL	1	0.900	-	-		OOG6_100519
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1047
SonicParanoid	1	1.000	-	-		X2793
TreeFam	1	0.960	-	-
	11	10.750