DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment r-l and Umps

DIOPT Version :9

Sequence 1:	NP_524427.1	Gene:	r-l / 42493	FlyBaseID:	FBgn0003257	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_033497.1	Gene:	Umps / 22247	MGIID:	1298388	Length:	481	Species:	Mus musculus

Alignment Length:	488	Identity:	222/488 - (45%)
Similarity:	315/488 - (64%)	Gaps:	14/488 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SDKMRALALKLFEINAFKFGDFKMKVGINSPVYFDLRVIVSYPDVMQTVSDLLVEHIKDKQLSAK 70
            |..:..|..:|:::.|||||.|.:|.|::||||.|||.|||.|.::..|:|:|.:..|:..:|..
Mouse     5 SQALGPLVTELYDVQAFKFGSFVLKSGLSSPVYIDLRGIVSRPRLLSQVADILFQTAKNAGISFD 69

  Fly    71 HVCGVPYTALPLATIVSVQQGTPMLVRRKEAKAYGTKKLVEGIFNAGDTCLIVEDVVTSGSSILD 135
            .|||||||||||||::......|||:||||.|.||||:||||..|.|.|||::|||||||:|:|:
Mouse    70 SVCGVPYTALPLATVICSANHIPMLIRRKETKDYGTKRLVEGEINPGQTCLVIEDVVTSGASVLE 134

  Fly   136 TVRDLQGEGIVVTDAVVVVDREQGGVANIAKHGVRMHSLFTLSFLLNTLHEAGRIEKSTVEAVAK 200
            ||..||.||:.||||:|::||||||...:...|:|:|::.|||.:|..|.:..:|:...|..|.:
Mouse   135 TVEVLQKEGLKVTDAIVLLDREQGGKDKLQAQGIRLHAVCTLSQMLEILQQQEKIDADMVGRVKR 199

  Fly   201 YIAAVQINSDGTFVGGDKGDVVRANDLQRTKLTYENRANL-AKSAVAKRLFNLIASKQTNLCLAA 264
            :|      .:..|...:...:.........:|::..||.| ....:|.:|..|:..|:|||||:|
Mouse   200 FI------QENVFSAANHNGLPPPEKKACKELSFGARAELPGTHPLASKLLRLMQKKETNLCLSA 258

  Fly   265 DLTHADEILDVADKCGPYICLLKTHVDIVEDFSDKFIADLQALAQRHNFLLMEDRKFADIGNTVS 329
            |::.|.|:|.:||..||.||:|||||||:.||:...:.:|.|||:||.||:.||||||||||||.
Mouse   259 DVSEARELLQLADALGPSICMLKTHVDILNDFTLDVMEELTALAKRHEFLIFEDRKFADIGNTVK 323

  Fly   330 LQYGKGIYKISSWADLVTAHTLPGRSILQGLKAGLGEGGAGKERGVFLLAEMSASGNLIDAKYKE 394
            .||..|.:||:||||:|.||.:||..:::||:    |.|....|...|:||||::|:|....|.:
Mouse   324 KQYESGTFKIASWADIVNAHVVPGSGVVKGLQ----EVGLPLHRACLLIAEMSSAGSLATGNYTK 384

  Fly   395 NSNKIATEGADVDFVAGVVCQSSDAFAFPGLLQLTPGVKIDEGVDQLGQQYQSPEHVVKERGADI 459
            .:..:|.|  ..:||.|.:..|..:.. |..|.|||||:::.|.|.|||||.||:.|:.:||:|:
Mouse   385 AAVGMAEE--HCEFVIGFISGSRVSMK-PEFLHLTPGVQLETGGDHLGQQYNSPQEVIGKRGSDV 446

  Fly   460 GVVGRGILKASSPKQAAQTYRDRLWAAYQDRVA 492
            .:||||||.|::..:||:.||...|.||..|:|
Mouse   447 IIVGRGILAAANRLEAAEMYRKAAWEAYLSRLA 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r-l	NP_524427.1	PRTases_typeI	1..202	CDD:294217	98/195 (50%)
r-l	NP_524427.1	OMPdecase	258..479	CDD:278637	107/220 (49%)
Umps	NP_033497.1	OPRTase	1..214		100/214 (47%)
		PRTases_typeI	9..204	CDD:294217	98/200 (49%)
		Domain linker	215..220		0/4 (0%)
		OMPdecase	221..481		122/266 (46%)
		OMPdecase	252..466	CDD:278637	107/220 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849799
Domainoid	1	1.000	207	1.000	Domainoid score	I2887
eggNOG	1	0.900	-	-		E1_COG0461
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H319
Inparanoid	1	1.050	416	1.000	Inparanoid score	I1806
Isobase	1	0.950	-	0.88686	Normalized mean entropy	S1042
OMA	1	1.010	-	-		QHG55508
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003431
OrthoInspector	1	1.000	-	-		oto93261
orthoMCL	1	0.900	-	-		OOG6_100519
Panther	1	1.100	-	-	LDO	PTHR19278
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1047
SonicParanoid	1	1.000	-	-		X2793
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740