DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment r-l and R12E2.11

DIOPT Version :9

Sequence 1:	NP_524427.1	Gene:	r-l / 42493	FlyBaseID:	FBgn0003257	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_491317.1	Gene:	R12E2.11 / 172008	WormBaseID:	WBGene00020036	Length:	227	Species:	Caenorhabditis elegans

Alignment Length:	186	Identity:	81/186 - (43%)
Similarity:	120/186 - (64%)	Gaps:	5/186 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LFEINAFKFGDFKMKVGINSPVYFDLRVIVSYPDVMQTVSDLLVEHIKDKQLSAKHVCGVPYTAL 80
            |:::..|:.|:|.:|.|..:|:|.|||.|:|.|.|::..:..:.|.|....|...:|.||||.||
Worm    37 LYQMECFRTGEFYLKSGQMTPIYIDLRRIMSSPRVLRMAAQAMCEKIVASNLKFDYVVGVPYAAL 101

  Fly    81 PLATIVSVQQGTPMLVRRKEAKAYGTKKLVEGIFNAGDTCLIVEDVVTSGSSILDTVRDLQGEGI 145
            ||||:||.....|||::||||||||||:|:||::..|.|.|:||||||||.||.:|...::.|.:
Worm   102 PLATLVSDILNVPMLMKRKEAKAYGTKQLIEGVYQPGGTVLLVEDVVTSGESIRETAEAIRNENL 166

  Fly   146 VVTDAVVVVDREQGGVANIAKHGVRMHSLFTLSFLLNTLHEAGRIEKSTVEAVAKY 201
            :||||:.|:||:||..||:|:..:...|..|:..:|:     |.|.|:.:....|:
Worm   167 LVTDAIAVLDRQQGATANLAEDNLNFLSFLTMEKILD-----GLITKNEMTEERKH 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
r-l	NP_524427.1	PRTases_typeI	1..202	CDD:294217	81/186 (44%)
r-l	NP_524427.1	OMPdecase	258..479	CDD:278637
R12E2.11	NP_491317.1	PyrE	32..221	CDD:223537	81/186 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I3812
eggNOG	1	0.900	-	-		E1_COG0461
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.88686	Normalized mean entropy	S1042
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1303452at2759
OrthoFinder	1	1.000	-	-		FOG0003431
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19278
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1047
SonicParanoid	1	1.000	-	-		X2793
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.900