DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB9 and ANXA9

DIOPT Version :9

Sequence 1:	NP_001262796.1	Gene:	AnxB9 / 42492	FlyBaseID:	FBgn0000083	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_003559.2	Gene:	ANXA9 / 8416	HGNCID:	547	Length:	345	Species:	Homo sapiens

Alignment Length:	302	Identity:	98/302 - (32%)
Similarity:	162/302 - (53%)	Gaps:	4/302 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FDPVEDAAILRKAMKGFGTDEKAIIEILARRGIVQRLEIAEAFKTSYGKDLISDLKSELGGKFED 85
            |...:||..|.:|:.|.|.|..||:::|..|...||..|:..|:....:||:..|::.|.|..|.
Human    41 FSVDKDAQRLLRAITGQGVDRSAIVDVLTNRSREQRQLISRNFQERTQQDLMKSLQAALSGNLER 105

  Fly    86 VILALMTPLPQFYAQELHDAISGLGTDEEAIIEILCTLSNYGIKTIAQFYEQSFGKSLESDLKGD 150
            :::||:.|..||.||||..|:....:..:..||||.|.:...::.....|:.:|......|:..:
Human   106 IVMALLQPTAQFDAQELRTALKASDSAVDVAIEILATRTPPQLQECLAVYKHNFQVEAVDDITSE 170

  Fly   151 TSGHFKRLCVSLVQGNRDENQG-VDEAAAIADAQALHDAGEGQWGTDESTFNSILITRSYQQLRQ 214
            |||..:.|.::|.:|.||...| :|...|..|.|||..| ||.  :.|.|:..:...|:.:.|.:
Human   171 TSGILQDLLLALAKGGRDSYSGIIDYNLAEQDVQALQRA-EGP--SREETWVPVFTQRNPEHLIR 232

  Fly   215 IFLEYENLSGNDIEKAIKREFSGSVEKGFLAIVKCCKSKIDYFSERLHDSMAGMGTKDKTLIRII 279
            :|.:|:..:|.::|:|::..|.|..:...|.:....|:...||:::||.::.......:.||||:
Human   233 VFDQYQRSTGQELEEAVQNRFHGDAQVALLGLASVIKNTPLYFADKLHQALQETEPNYQVLIRIL 297

  Fly   280 VSRSEIDLGDIKEAFQNKYGKSLESWIKGDTSGDYKRALLAI 321
            :||.|.||..|:..|:.|:||||.|.::....||.:.||||:
Human   298 ISRCETDLLSIRAEFRKKFGKSLYSSLQDAVKGDCQSALLAL 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB9	NP_001262796.1	Annexin	26..90	CDD:395139	21/63 (33%)
		Annexin	97..162	CDD:395139	18/64 (28%)
		Annexin	188..246	CDD:395139	15/57 (26%)
		Annexin	256..321	CDD:395139	26/64 (41%)
ANXA9	NP_003559.2	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	41..112		24/70 (34%)
		Annexin	46..110	CDD:278615	21/63 (33%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	113..184		21/70 (30%)
		Annexin	117..182	CDD:278615	18/64 (28%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	197..266		20/71 (28%)
		Annexin	201..264	CDD:278615	19/65 (29%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	270..341		27/70 (39%)
		Annexin	274..339	CDD:278615	26/64 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141937
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D856254at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.760