DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB9 and ANXA8L1

DIOPT Version :9

Sequence 1:	NP_001262796.1	Gene:	AnxB9 / 42492	FlyBaseID:	FBgn0000083	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001092315.2	Gene:	ANXA8L1 / 728113	HGNCID:	23334	Length:	327	Species:	Homo sapiens

Alignment Length:	311	Identity:	161/311 - (51%)
Similarity:	215/311 - (69%)	Gaps:	1/311 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TVYPADPFDPVEDAAILRKAMKGFGTDEKAIIEILARRGIVQRLEIAEAFKTSYGKDLISDLKSE 78
            ||..:..|:|..||..|.|||||.||:|:|||::|.:|...||.:||::||..:||||...||||
Human    14 TVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSE 78

  Fly    79 LGGKFEDVILALMTPLPQFYAQELHDAISGLGTDEEAIIEILCTLSNYGIKTIAQFYEQSFGKSL 143
            |.||||.:|:|||.|..::.|:|||||:.||||.|..|||||.:.:...::.|.:.||:.:|.||
Human    79 LSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSL 143

  Fly   144 ESDLKGDTSGHFKRLCVSLVQGNRDE-NQGVDEAAAIADAQALHDAGEGQWGTDESTFNSILITR 207
            |.|::.||||:.:|:.|.|:||:||: :..||.|.|:.|||.|:.|||...||||..|.:||.||
Human   144 EEDIQADTSGYLERILVCLLQGSRDDVSSFVDPALALQDAQDLYAAGEKIRGTDEMKFITILCTR 208

  Fly   208 SYQQLRQIFLEYENLSGNDIEKAIKREFSGSVEKGFLAIVKCCKSKIDYFSERLHDSMAGMGTKD 272
            |...|.::|.|||.::...||.:||.|..||:|:..|.:|||.::...||:|||:.:|.|.||:|
Human   209 SATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRD 273

  Fly   273 KTLIRIIVSRSEIDLGDIKEAFQNKYGKSLESWIKGDTSGDYKRALLAIVG 323
            .||||.|||||||||..||..|:..|||:|.|.|..|||||||.|||::||
Human   274 GTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVG 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB9	NP_001262796.1	Annexin	26..90	CDD:395139	36/63 (57%)
		Annexin	97..162	CDD:395139	30/64 (47%)
		Annexin	188..246	CDD:395139	27/57 (47%)
		Annexin	256..321	CDD:395139	42/64 (66%)
ANXA8L1	NP_001092315.2	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	21..92		40/70 (57%)
		Annexin	26..90	CDD:395139	36/63 (57%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	93..164		32/70 (46%)
		Annexin	97..162	CDD:395139	30/64 (47%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	177..249		33/71 (46%)
		Annexin	181..247	CDD:395139	31/65 (48%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	253..324		42/70 (60%)
		Annexin	257..322	CDD:395139	42/64 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141934
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760