DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB9 and Anxa2

DIOPT Version :9

Sequence 1:	NP_001262796.1	Gene:	AnxB9 / 42492	FlyBaseID:	FBgn0000083	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_063970.1	Gene:	Anxa2 / 56611	RGDID:	621170	Length:	339	Species:	Rattus norvegicus

Alignment Length:	316	Identity:	132/316 - (41%)
Similarity:	199/316 - (62%)	Gaps:	5/316 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PTVY----PADPFDPVEDAAILRKAMKGFGTDEKAIIEILARRGIVQRLEIAEAFKTSYGKDLIS 73
            |:.|    |...||...||..:..|:|..|.||..|:.||..|...||.:||.|::....|:|.|
  Rat    21 PSAYGSVKPYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELPS 85

  Fly    74 DLKSELGGKFEDVILALMTPLPQFYAQELHDAISGLGTDEEAIIEILCTLSNYGIKTIAQFYEQS 138
            .:||.|.|..|.|:|.|:....|:.|.||..::.||||||:::|||:|:.:|..::.|.:.|::.
  Rat    86 AMKSALSGHLETVMLGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM 150

  Fly   139 FGKSLESDLKGDTSGHFKRLCVSLVQGNRDENQGVDEAAAI-ADAQALHDAGEGQWGTDESTFNS 202
            :...||.|:..||||.|::|.|:|.:|.|.|:..|.:...| .||:.|:|||..:.|||...:.|
  Rat   151 YKTDLEKDIISDTSGEFRKLLVALAKGKRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWIS 215

  Fly   203 ILITRSYQQLRQIFLEYENLSGNDIEKAIKREFSGSVEKGFLAIVKCCKSKIDYFSERLHDSMAG 267
            |:..||...|:::|..|::.|..|:.::|::|..|.:|..||.:|:|.::|..||::||:|||.|
  Rat   216 IMTERSVCHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG 280

  Fly   268 MGTKDKTLIRIIVSRSEIDLGDIKEAFQNKYGKSLESWIKGDTSGDYKRALLAIVG 323
            .||:||.||||:|||||:|:..|:..|:.||||||..:|:.||.|||::|||.:.|
  Rat   281 KGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYFIQQDTKGDYQKALLYLCG 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB9	NP_001262796.1	Annexin	26..90	CDD:395139	26/63 (41%)
		Annexin	97..162	CDD:395139	26/64 (41%)
		Annexin	188..246	CDD:395139	20/57 (35%)
		Annexin	256..321	CDD:395139	39/64 (61%)
Anxa2	NP_063970.1	S100A10-binding site. /evidence=ECO:0000255	2..24		1/2 (50%)
		Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	33..104		29/70 (41%)
		Annexin	37..102	CDD:395139	26/64 (41%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	105..176		28/70 (40%)
		Annexin	109..174	CDD:395139	26/64 (41%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	189..261		25/71 (35%)
		Annexin	193..259	CDD:395139	24/65 (37%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	265..336		40/70 (57%)
		Annexin	269..334	CDD:395139	39/64 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335640
Domainoid	1	1.000	72	1.000	Domainoid score	I9085
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.760