DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB9 and anxa2a

DIOPT Version :9

Sequence 1:	NP_001262796.1	Gene:	AnxB9 / 42492	FlyBaseID:	FBgn0000083	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_861426.1	Gene:	anxa2a / 325557	ZFINID:	ZDB-GENE-030131-4282	Length:	337	Species:	Danio rerio

Alignment Length:	315	Identity:	141/315 - (44%)
Similarity:	199/315 - (63%)	Gaps:	11/315 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PTVYPADPFDPVEDAAILRKAMKGFGTDEKAIIEILARRGIVQRLEIAEAFKTSYGKDLISDLKS 77
            |||.|...|||.:|||.:..|:|..|.||:.||:||.:|...||.|||.|::....||:||.||.
Zfish    23 PTVVPEANFDPDKDAARIETAIKTKGVDEQTIIDILTKRTYNQRREIAFAYERRAKKDMISALKG 87

  Fly    78 ELGGKFEDVILALMTPLPQFYAQELHDAISGLGTDEEAIIEILCTLSNYGIKTIAQFYEQSFGKS 142
            .|.|..|.|||.||....|:.|.|:..:|.|||||||::|||||:.||..|..|.:.|.:.|.|.
Zfish    88 ALSGSLETVILGLMKSTAQYDASEIKASIKGLGTDEESLIEILCSRSNAEIMEIKKVYRELFKKE 152

  Fly   143 LESDLKGDTSGHFKRLCVSLVQGNRDEN------QGVDEAAAIADAQALHDAGEGQWGTDESTFN 201
            ||.|:.|||||.|.:|.::||:..|::.      |.:||     ||:||:|||..:.|||...:.
Zfish   153 LEKDVAGDTSGDFAKLLLALVEAKREQTSSVIDYQRIDE-----DARALYDAGVKRKGTDVKCWI 212

  Fly   202 SILITRSYQQLRQIFLEYENLSGNDIEKAIKREFSGSVEKGFLAIVKCCKSKIDYFSERLHDSMA 266
            ||:..||...|:::|..|::.|..|::::|::|..|.:||.||.:|:|.::|..||:.||.|:|.
Zfish   213 SIMSERSVPHLQKVFDRYKSYSPYDMQESIRKEVKGDLEKSFLTLVQCFENKQLYFASRLQDAMK 277

  Fly   267 GMGTKDKTLIRIIVSRSEIDLGDIKEAFQNKYGKSLESWIKGDTSGDYKRALLAI 321
            ..|.|:|.|.||:|||.|:||..|::.|:..:||||...|...|.|||:||||::
Zfish   278 SKGAKEKVLTRIMVSRCEVDLKKIRQEFKQHFGKSLHQTIAEHTKGDYQRALLSL 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB9	NP_001262796.1	Annexin	26..90	CDD:395139	31/63 (49%)
		Annexin	97..162	CDD:395139	32/64 (50%)
		Annexin	188..246	CDD:395139	21/57 (37%)
		Annexin	256..321	CDD:395139	33/64 (52%)
anxa2a	NP_861426.1	Annexin	36..100	CDD:278615	31/63 (49%)
		Annexin	107..172	CDD:278615	32/64 (50%)
		Annexin	192..257	CDD:278615	26/64 (41%)
		Annexin	267..332	CDD:278615	33/64 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574820
Domainoid	1	1.000	69	1.000	Domainoid score	I9568
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.760