DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB9 and ANXA5

DIOPT Version :9

Sequence 1:	NP_001262796.1	Gene:	AnxB9 / 42492	FlyBaseID:	FBgn0000083	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001145.1	Gene:	ANXA5 / 308	HGNCID:	543	Length:	320	Species:	Homo sapiens

Alignment Length:	312	Identity:	158/312 - (50%)
Similarity:	213/312 - (68%)	Gaps:	2/312 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TPTVYPADPFDPVEDAAILRKAMKGFGTDEKAIIEILARRGIVQRLEIAEAFKTSYGKDLISDLK 76
            |.|.:|.  ||...||..|||||||.||||::|:.:|..|...||.||:.||||.:|:||:.|||
Human     8 TVTDFPG--FDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLK 70

  Fly    77 SELGGKFEDVILALMTPLPQFYAQELHDAISGLGTDEEAIIEILCTLSNYGIKTIAQFYEQSFGK 141
            |||.||||.:|:|||.|...:.|.||..|:.|.||:|:.:.||:.:.:...::.|.|.||:.:|.
Human    71 SELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYGS 135

  Fly   142 SLESDLKGDTSGHFKRLCVSLVQGNRDENQGVDEAAAIADAQALHDAGEGQWGTDESTFNSILIT 206
            |||.|:.|||||:::|:.|.|:|.|||.:.|:|||....|||||..|||.:|||||..|.:|..|
Human   136 SLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGT 200

  Fly   207 RSYQQLRQIFLEYENLSGNDIEKAIKREFSGSVEKGFLAIVKCCKSKIDYFSERLHDSMAGMGTK 271
            ||...||::|.:|..:||..||:.|.||.||::|:..||:||..:|...|.:|.|:.:|.|.||.
Human   201 RSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTD 265

  Fly   272 DKTLIRIIVSRSEIDLGDIKEAFQNKYGKSLESWIKGDTSGDYKRALLAIVG 323
            |.||||::||||||||.:|::.|:..:..||.|.||||||||||:|||.:.|
Human   266 DHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCG 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB9	NP_001262796.1	Annexin	26..90	CDD:395139	38/63 (60%)
		Annexin	97..162	CDD:395139	26/64 (41%)
		Annexin	188..246	CDD:395139	28/57 (49%)
		Annexin	256..321	CDD:395139	38/64 (59%)
ANXA5	NP_001145.1	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	15..86		42/70 (60%)
		Annexin	20..84	CDD:395139	38/63 (60%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	87..158		28/70 (40%)
		Annexin	91..156	CDD:395139	26/64 (41%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	170..242		35/71 (49%)
		Annexin	174..240	CDD:395139	33/65 (51%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	246..317		39/70 (56%)
		Annexin	250..315	CDD:395139	38/64 (59%)
		[IL]-x-C-x-x-[DE] motif. /evidence=ECO:0000305\|PubMed:25417112	314..319		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141919
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760