DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AnxB9 and ANXA3

DIOPT Version :9

Sequence 1:	NP_001262796.1	Gene:	AnxB9 / 42492	FlyBaseID:	FBgn0000083	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_005130.1	Gene:	ANXA3 / 306	HGNCID:	541	Length:	323	Species:	Homo sapiens

Alignment Length:	308	Identity:	146/308 - (47%)
Similarity:	198/308 - (64%)	Gaps:	2/308 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YPADPFDPVEDAAILRKAMKGFGTDEKAIIEILARRGIVQRLEIAEAFKTSYGKDLISDLKSELG 80
            ||  .|.|..||..::||::|.|||||.:|.||..|...||..|.:.::.:|||:|..|||.:|.
Human    15 YP--DFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKELKDDLKGDLS 77

  Fly    81 GKFEDVILALMTPLPQFYAQELHDAISGLGTDEEAIIEILCTLSNYGIKTIAQFYEQSFGKSLES 145
            |.||.:::||:||...|.|::|..::.|.||:|:|:||||.|.::..:|.|:|.|...:.|||..
Human    78 GHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGD 142

  Fly   146 DLKGDTSGHFKRLCVSLVQGNRDENQGVDEAAAIADAQALHDAGEGQWGTDESTFNSILITRSYQ 210
            |:..:|||.|::..::|..|.|||:..|||..|..|||.|:.|||.:|||||..|..||..||:.
Human   143 DISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFP 207

  Fly   211 QLRQIFLEYENLSGNDIEKAIKREFSGSVEKGFLAIVKCCKSKIDYFSERLHDSMAGMGTKDKTL 275
            ||:..|.||.|:|..||..:||.|.||..|...||||.|.::...:.:||||.::.|:||.:.||
Human   208 QLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTL 272

  Fly   276 IRIIVSRSEIDLGDIKEAFQNKYGKSLESWIKGDTSGDYKRALLAIVG 323
            .||:||||||||.||:..|:..||.||.|.||.||||||:..||.|.|
Human   273 NRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKICG 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AnxB9	NP_001262796.1	Annexin	26..90	CDD:395139	28/63 (44%)
		Annexin	97..162	CDD:395139	25/64 (39%)
		Annexin	188..246	CDD:395139	29/57 (51%)
		Annexin	256..321	CDD:395139	37/64 (58%)
ANXA3	NP_005130.1	Annexin 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	18..89		32/70 (46%)
		Annexin	23..87	CDD:278615	28/63 (44%)
		Annexin 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	90..161		27/70 (39%)
		Annexin	94..159	CDD:278615	25/64 (39%)
		Annexin 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	173..245		36/71 (51%)
		Annexin	177..243	CDD:278615	33/65 (51%)
		Annexin 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01245	249..320		38/70 (54%)
		Annexin	255..318	CDD:278615	37/62 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141929
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0819
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54302
OrthoDB	1	1.010	-	-		D500720at33208
OrthoFinder	1	1.000	-	-		FOG0000105
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X76
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760