DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cortactin and ABP1

DIOPT Version :9

Sequence 1:	NP_001247222.1	Gene:	Cortactin / 42491	FlyBaseID:	FBgn0025865	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_010012.1	Gene:	ABP1 / 850450	SGDID:	S000000684	Length:	592	Species:	Saccharomyces cerevisiae

Alignment Length:	551	Identity:	126/551 - (22%)
Similarity:	205/551 - (37%)	Gaps:	143/551 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 EQADLDKKKQLLKDQNAGYGYGGKFGVEKDR----------MDKSAVGHDYQGKVGKHASQKDYS 119
            ::.|||:.:.|:|..||.   |.::.::...          :.||.........|.|....|..|
Yeast   122 DEDDLDENELLMKISNAA---GARYSIQTSSKQQGKASTPPVKKSFTPSKSPAPVSKKEPVKTPS 183

  Fly   120 DGFGGKFG--VQEDRKDKSAVGWDHVEKVEKHASQKDYATGFGGKFGVQSDRVDKSAVGWDHIEK 182
            .....|..  |.::..|..   |:..|..|:...|..          ::.::.....:|...::|
Yeast   184 PAPAAKISSRVNDNNDDDD---WNEPELKERDFDQAP----------LKPNQSSYKPIGKIDLQK 235

  Fly   183 VEKHESQKDYSK------GFGGKFGVQED---RKDKSAVGWDHK--------EAPQKHASQVDHK 230
            |...|..|:..:      ..|.|.....|   .|::|.:..|.:        :.|....|.:.:.
Yeast   236 VIAEEKAKEDPRLVQKPTAAGSKIDPSSDIANLKNESKLKRDSEFNSFLGTTKPPSMTESSLKND 300

  Fly   231 VKPVIEGAK----PSNLRAKFENLAKNSEEESRKRAE---------EQKRLREAKDKRDREEAAK 282
            ...||:|.:    |:.|.|  |..||.:...:..:||         |.:...:.||.:.:.|...
Yeast   301 DDKVIKGFRNEKSPAQLWA--ERKAKQNSGNAETKAEAPKPEVPEDEPEGEPDVKDLKSKFEGLA 363

  Fly   283 KTVAENTPRTSTEAPPPKGSRAAIQTGRTGGIGNAISAFNQMQSPV----SETPPARKEPIIIPK 343
            .:..|.....:..|||||.|...|.:.:         .|::.|.||    :|.|....:.|..|
Yeast   364 ASEKEEEEMENKFAPPPKKSEPTIISPK---------PFSKPQEPVKAEEAEQPKTDYKKIGNP- 418

  Fly   344 AQPVKIELEAKEEPTAS-------TTSAAVAPTPTVVPAREPET-APVAKAAAPPPDVVPQIEVE 400
            ...:.||.:.:|||..:       ...||..|    :|:|...: |||.|......::.|.:
Yeast   419 LPGMHIEADNEEEPEENDDDWDDDEDEAAQPP----LPSRNVASGAPVQKEEPEQEEIAPSL--- 476

  Fly   401 TVDTPPRSEPQSPVYVPTPQPEVHAQVQVQPEPQPQADPEPVVEEE-----PLYQNQAEIKAASP 460
                |.|:.      :|.|          :.|..|:..||..:|||     |  |..:...||.|
Yeast   477 ----PSRNS------IPAP----------KQEEAPEQAPEEEIEEEAEEAAP--QLPSRSSAAPP 519

  Fly   461 LPPTNGTVSEAVAPSGTATVPEEAIYANSDNLADYLEDTGIHAIALYDYQAADDDEISFDPDDVI 525
            .||...|..:.         |:|..:|.::                |||.||:|:|::|..:|.|
Yeast   520 PPPRRATPEKK---------PKENPWATAE----------------YDYDAAEDNELTFVENDKI 559

  Fly   526 THIEKIDDGWWRGLCK--NRYGLFPANYVQV 554
            .:||.:||.||.|..:  ...||||:|||.:
Yeast   560 INIEFVDDDWWLGELEKDGSKGLFPSNYVSL 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cortactin	NP_001247222.1	HS1_rep	84..119	CDD:396686	6/44 (14%)
		HS1_rep	121..156	CDD:396686	7/36 (19%)
		HS1_rep	158..193	CDD:396686	5/34 (15%)
		HS1_rep	195..229	CDD:396686	8/44 (18%)
		rne	<327..489	CDD:236766	43/178 (24%)
		SH3_Cortactin	502..554	CDD:212892	24/53 (45%)
ABP1	NP_010012.1	ADF_drebrin_like	6..141	CDD:200437	7/21 (33%)
		PTZ00108	<148..404	CDD:240271	53/279 (19%)
		SH3_Abp1_fungi_C2	536..590	CDD:212894	25/69 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I2900
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46800
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10829
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100