DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cortactin and Cttn

DIOPT Version :9

Sequence 1:NP_001247222.1 Gene:Cortactin / 42491 FlyBaseID:FBgn0025865 Length:559 Species:Drosophila melanogaster
Sequence 2:XP_006230684.1 Gene:Cttn / 60465 RGDID:619839 Length:546 Species:Rattus norvegicus


Alignment Length:666 Identity:258/666 - (38%)
Similarity:314/666 - (47%) Gaps:234/666 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MWKASAGHQIQATSAASAED---DDWETDPDFVNDVSEQEQRWGSKTIDGSGRTAGTIDMDKLRE 62
            ||||||||.:..|.    :|   |||||||||||||||:|||||:||:.|||... .|::.||||
  Rat     1 MWKASAGHAVSITQ----DDGGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQE-HINIHKLRE 60

  Fly    63 ET-EQADLDKKKQLLKDQNAGYGYGGKFGVEKDRMDKSAVGH----------------------- 103
            .. ::....|:|:|.....|.:|||||||||:||||||||||                       
  Rat    61 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRGFGGKF 125

  Fly   104 --------------DYQGKVGKHASQKDYSDGFGGKFGVQEDRKDKSAVGWDHVEKVEKHASQKD 154
                          :||||..|||||||||.|||||:|||.||.||||||:|:..|.|||.||||
  Rat   126 GVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQKD 190

  Fly   155 YATGFGGKFGVQSDRVDKSAVGWDHIEKVEKHESQKDYSKGFGGKFGVQEDRKDKSAVGWDHKEA 219
            |:.|||||:|:..|:|||||||:::..|.|||||||||.||||||||||.||:||.|:||||:|.
  Rat   191 YSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEK 255

  Fly   220 PQKHASQVDHKV----------------------------------------------------- 231
            .|.|.||.|:|.                                                     
  Rat   256 LQLHESQKDYKTGFGGKFGVQSERQDSSAVGFDYKEKLAKHESQQDYAKGFGGKYGVQKDRMDKN 320

  Fly   232 ---------------KPV-IEG--AKPSNLRAKFENLAKNSEEESRKRAEEQKRLREAKDKRDRE 278
                           |.| ||.  :|.||:||.||||||..|:|.|::||.::..|.|::::::|
  Rat   321 ASTFEEVVQVPSAYQKTVPIEAVTSKTSNIRANFENLAKEREQEDRRKAEAERAQRMAQERQEQE 385

  Fly   279 EAAKKTVAENTPRTSTEAPPPKGSRAAIQTGRTGGIGNAISAFNQMQSPVSETPPARKEPIIIPK 343
            ||.:|  .|...|...:.||...|                      ..|..:.||:..   |...
  Rat   386 EARRK--LEEQARAKKQTPPASPS----------------------PQPAEDRPPSSP---IYED 423

  Fly   344 AQPVKIELEAKEEPTASTTSAAVAPTPTVVPAREPETAPVAKAAAPPPDVVPQIEVETVDTPPRS 408
            |.|:      |.||:..::              |||               |:...|....|..|
  Rat   424 AAPL------KAEPSYGSS--------------EPE---------------PEYSTEAAGLPEAS 453

  Fly   409 EPQSPVYVPTPQPEVHAQVQVQPEPQPQADPEPVVEEEPLYQNQAEIKAASPLPPTNGTVSEAVA 473
            ..|...|.                            .||:|:                       
  Rat   454 NQQGLAYT----------------------------SEPVYE----------------------- 467

  Fly   474 PSGTATVPEEAIYANSDNLADYLEDTGIHAIALYDYQAADDDEISFDPDDVITHIEKIDDGWWRG 538
               |..||.. ..|..|....|..|.||.||||||||||.|||||||||||||:||.||||||||
  Rat   468 ---TTEVPGH-YQAEDDTYDGYESDLGITAIALYDYQAAGDDEISFDPDDVITNIEMIDDGWWRG 528

  Fly   539 LCKNRYGLFPANYVQV 554
            :||.||||||||||::
  Rat   529 VCKGRYGLFPANYVEL 544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CortactinNP_001247222.1 HS1_rep 84..119 CDD:396686 30/71 (42%)
HS1_rep 121..156 CDD:396686 25/34 (74%)
HS1_rep 158..193 CDD:396686 23/34 (68%)
HS1_rep 195..229 CDD:396686 23/33 (70%)
rne <327..489 CDD:236766 25/161 (16%)
SH3_Cortactin 502..554 CDD:212892 45/51 (88%)
CttnXP_006230684.1 HS1_rep 83..116 CDD:396686 19/32 (59%)
HS1_rep 120..155 CDD:396686 11/34 (32%)
HS1_rep 157..192 CDD:396686 25/34 (74%)
HS1_rep 194..228 CDD:396686 22/33 (67%)
HS1_rep 231..265 CDD:396686 23/33 (70%)
HS1_rep 268..303 CDD:396686 0/34 (0%)
HS1_rep 305..>330 CDD:396686 0/24 (0%)
DUF4670 <357..400 CDD:406200 16/44 (36%)
SH3_Cortactin 492..544 CDD:212892 45/51 (88%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 99 1.000 Domainoid score I6959
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3834
Inparanoid 1 1.050 392 1.000 Inparanoid score I1918
OMA 1 1.010 - - QHG48031
OrthoDB 1 1.010 - - D1243441at2759
OrthoFinder 1 1.000 - - FOG0004044
OrthoInspector 1 1.000 - - oto95681
orthoMCL 1 0.900 - - OOG6_105161
Panther 1 1.100 - - O PTHR10829
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2789
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.980

Return to query results.
Submit another query.