DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cortactin and hcls1

DIOPT Version :9

Sequence 1:	NP_001247222.1	Gene:	Cortactin / 42491	FlyBaseID:	FBgn0025865	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_005164938.1	Gene:	hcls1 / 563056	ZFINID:	ZDB-GENE-030131-7191	Length:	550	Species:	Danio rerio

Alignment Length:	676	Identity:	228/676 - (33%)
Similarity:	317/676 - (46%)	Gaps:	247/676 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWKASAGHQIQATSAASAEDDDWETDPDFVNDVSEQEQRWGSKTIDGSGRTAGTIDMDKLREETE 65
            |||:..||.:  |....::.|||||||:|.|||||||||||:|||:||||.......|..:..:.
Zfish     1 MWKSVVGHDV--TVETESQGDDWETDPNFENDVSEQEQRWGAKTIEGSGRKEHISIADLRQNVSR 63

  Fly    66 QADLDKKKQLLKDQNAGYGYGGKFGVEKDRMDKSAVGH--------------------------- 103
            :.::.|||:|.:...|.||||||||||||||||.|:||
Zfish    64 EHEVVKKKELDQGPKASYGYGGKFGVEKDRMDKGALGHSYVAEVEQHSSQTDAAKGFGGKFGVQK 128

  Fly   104 ----------DYQGKVGKHASQKDYSDGFGGKFGVQEDRKDKSAVGWDHVEKVEKHASQKDYATG 158
                      :|:.:|.:|||||||:.|||||:|||::|.||:|:|:|:..:.|||.||||||.|
Zfish   129 DRVDKSAMSYEYKAQVQQHASQKDYAQGFGGKYGVQKERVDKAAMGYDYKGETEKHQSQKDYAKG 193

  Fly   159 FGGKFGVQSDRVDKSAVGWDHIEKVEKHESQKDYSKGFGGKFGVQEDRKDKSAVGWDHKEAPQKH 223
            ||||:||:.::|||:|:|:|:..:.|||:|||||:||||||:||::::.||:|:|:|:|...:||
Zfish   194 FGGKYGVEKEKVDKAAMGYDYKGETEKHQSQKDYAKGFGGKYGVEKEKVDKAALGYDYKGETEKH 258

  Fly   224 ASQVDH-------------KV-------------------------------------------- 231
            .||.|:             ||
Zfish   259 QSQKDYAKGFGGKYGVEKEKVDKAALGYDYKGETEKHQSQKDYAKGFGGRYGVQEDRMDKNASSF 323

  Fly   232 -----------KP-VIEGAK--PSNLRAKFENLAKNSEEESRKRAEEQKRLREAKDKRDREEAAK 282
                       || ..||:.  ..||:|.|||:||.|:|:::|:|||::..|.|::||:||||.:
Zfish   324 NKMESPSSSYEKPQAFEGSSVGAGNLKACFENMAKASDEDNKKKAEEERTRRLAREKREREEARR 388

  Fly   283 KTVAENTPRTSTE--APPPKGSRAAIQTGRTGGIGNAISAFNQMQSPVSETPPA--RKEPIIIPK 343
            |. .|.:.....|  :|||                          .|||:.|..  ||.|.|
Zfish   389 KQ-EEQSQHVEEEKQSPPP--------------------------VPVSQKPQQEFRKLPEI--- 423

  Fly   344 AQPVKIELEAKEEPTASTTSAAVAPTPTVVPAREPETAPVAKAAAPPPDVVPQIEVETVDTPPRS 408
                                                         |..::.|.:|.|  :.|...
Zfish   424 ---------------------------------------------PREEIEPDVEEE--NQPENE 441

  Fly   409 EPQSPVYVPTPQPEVHAQVQVQPEPQPQADPEPVVEEEPLYQNQAEIKAASPLPPTNGTVSEAVA 473
            ||.|                :.|.|....:.|...|.||              ||
Zfish   442 EPPS----------------LPPRPSDLLEDETYAECEP--------------PP---------- 466

  Fly   474 PSGTATVPEEAIYANSDNLA------DYLEDT---GIHAIALYDYQAADDDEISFDPDDVITHIE 529
                  ||:|..|.:..:.:      || ||.   |..|.|:||||..|.|||||.|||:||:||
Zfish   467 ------VPQEEDYEDVGSYSAQAGENDY-EDLGGGGTTARAIYDYQGEDSDEISFMPDDIITNIE 524

  Fly   530 KIDDGWWRGLCKNRYGLFPANYVQVV 555
            .:|:|||:|:|..|.|||||::|:::
Zfish   525 MVDEGWWKGMCNGRTGLFPASFVELL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cortactin	NP_001247222.1	HS1_rep	84..119	CDD:396686	26/71 (37%)
		HS1_rep	121..156	CDD:396686	21/34 (62%)
		HS1_rep	158..193	CDD:396686	20/34 (59%)
		HS1_rep	195..229	CDD:396686	17/33 (52%)
		rne	<327..489	CDD:236766	28/163 (17%)
		SH3_Cortactin	502..554	CDD:212892	32/51 (63%)
hcls1	XP_005164938.1	HS1_rep	82..117	CDD:280396	18/34 (53%)
		HS1_rep	119..154	CDD:280396	8/34 (24%)
		HS1_rep	156..191	CDD:280396	21/34 (62%)
		HS1_rep	193..228	CDD:280396	20/34 (59%)
		HS1_rep	230..265	CDD:280396	18/34 (53%)
		HS1_rep	267..302	CDD:280396	2/34 (6%)
		HS1_rep	304..>330	CDD:280396	0/25 (0%)
		SH3	497..549	CDD:302595	32/51 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8452
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	374	1.000	Inparanoid score	I2062
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1243441at2759
OrthoFinder	1	1.000	-	-		FOG0004044
OrthoInspector	1	1.000	-	-		otm26036
orthoMCL	1	0.900	-	-		OOG6_105161
Panther	1	1.100	-	-	LDO	PTHR10829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5379
SonicParanoid	1	1.000	-	-		X2789
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.000