Protein Alignment Cortactin and dbnlb

DIOPT Version :9

• Sequence 1: NP_001247222.1
• Gene: Cortactin / 42491
• FlyBaseID: FBgn0025865
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: XP_005167394.1
• Gene: dbnlb / 553729
• ZFINID: ZDB-GENE-050522-293
• Length: 476
• Species: Danio rerio
• Alignment Length: 580
• Identity: 140/580 - (24%)
• Similarity: 222/580 - (38%)
• Gaps: 175/580 - (30%)

  Fly    31 NDV--SEQEQRWGSKTIDGSG---RTA--GTIDMDKLREETEQADLDKKKQLLKDQNAG------ 82
            |:|  .:.|..|...|.:|:.   |.|  |...::::.||.....:......:||.|:|
Zfish    17 NEVVGEKSETNWVLFTYEGNTNDIRLAEKGDGGLEEMVEELNSGKVMYGFCRVKDPNSGLPKYVL 81

  Fly    83 YGYGGKFGVEKDRMDKSAVGHDYQGKVGKH-ASQKDYSDGFGGKFGVQ-EDRKDKSAVGWDHVEK 145
            ..:.|: ||:..|          :|:...| :|..::..|.......: |:..:..||    :||
Zfish    82 INWTGE-GVKDAR----------KGQCANHVSSMANFLKGAHVTINARAEEDVEPDAV----MEK 131

  Fly   146 VEKHASQKDYATGFGGKFGVQSDRVDKSA----VG--------------------WDHIEKVEKH 186
            |.|       |:|....|..::.|...|.    ||                    |...||.|:.
Zfish   132 VAK-------ASGANYSFHKETSRFRDSGPQGPVGSVYQKTNAMSEIKKTNKDTFWAQAEKDEEK 189

  Fly   187 ESQKDYSKGFGGKFGVQEDRKDKSAVGWDHKEA------PQKHASQVDHKVKPVIEGAKPSNLRA 245
            ..|::..:....:..::::|||:     :.|||      .::.|||:|
Zfish   190 RLQEEKRRAVDERQQLEKERKDR-----EMKEAELRDKKTKERASQID----------------- 232

  Fly   246 KFENLAKNSEEESRKRAEEQKRLREAKDKRDREEAAKKTVAENTPRTSTEAPPPKGSRAAIQTGR 310
                       |.||..::|.....|:.|:..||..||..|:..|....|:.......||:.:.|
Zfish   233 -----------EQRKYQQKQDVDNRAQQKQLEEEEEKKQAAQQKPFYRGESVEKANEAAALVSQR 286

  Fly   311 TGGIGNAISAFNQMQSPVSETPPARKEPIIIPKAQPVKIELEAKEEPTASTTSAAVAPTPTVVPA 375
            :   .|....|.|.:..::                |...:...:..|.....::......:..|
Zfish   287 S---VNPREMFKQREMGIN----------------PTNTDSNTQSSPKPGRLNSPFLSKQSCDP- 331

  Fly   376 REPETAPVAKAAAPPPDVVPQIEVETVDTPPRSEPQSPVYVPTPQPEVHAQ---VQV------QP 431
             ||..:|| :.|:|....|...|.:     |||:     ||.. :.|..|:   |||      .|
Zfish   332 -EPFRSPV-RQASPLRAAVASFEEQ-----PRSQ-----YVEA-EAEAEAEYEDVQVVSDKYEAP 383

  Fly   432 EPQPQADPEPVVEEEPLYQNQAEIKAASPLPPTNGTVSEAVAPSGTATVPEEAIYANSDNLADYL 496
            ..|.|...|.|.|.:.:|:|..:::..|...|                                :
Zfish   384 VEQQQPQYEAVEEPDAVYENPTQVEEQSTYEP--------------------------------V 416

  Fly   497 EDTGIHAIALYDYQAADDDEISFDPDDVITHIEKIDDGWWRGLCKN-RYGLFPANYVQVV 555
            ::.|:.|.||||||||||.||||||||:||.||.||:|||||...: .:|:||||||:::
Zfish   417 DERGVCARALYDYQAADDTEISFDPDDIITSIEMIDEGWWRGYGPDGHFGMFPANYVELL 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cortactin	NP_001247222.1	HS1_rep	84..119	CDD:396686	7/35 (20%)
		HS1_rep	121..156	CDD:396686	8/35 (23%)
		HS1_rep	158..193	CDD:396686	11/58 (19%)
		HS1_rep	195..229	CDD:396686	9/39 (23%)
		rne	<327..489	CDD:236766	31/170 (18%)
		SH3_Cortactin	502..554	CDD:212892	37/52 (71%)
dbnlb	XP_005167394.1	ADF_drebrin_like	3..138	CDD:200437	31/142 (22%)
		RILP-like	182..>243	CDD:304877	18/93 (19%)
		SH3_Abp1_eu	422..475	CDD:212893	37/52 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910