DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cortactin and dbnla

DIOPT Version :9

Sequence 1:	NP_001247222.1	Gene:	Cortactin / 42491	FlyBaseID:	FBgn0025865	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001002201.1	Gene:	dbnla / 431748	ZFINID:	ZDB-GENE-040704-42	Length:	496	Species:	Danio rerio

Alignment Length:	488	Identity:	135/488 - (27%)
Similarity:	198/488 - (40%)	Gaps:	136/488 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 GVQEDRKDKSAVGWDHVEKVEKHASQKDYATGFGGKFGVQS-DRVDKSAVGWDHIEKVEKHESQK 190
            ||::.||...|   .||.      |..::..|.......:| |.|:.:|:    :|||
Zfish    86 GVKDLRKGVCA---RHVH------SMANFLRGAHVTINARSDDDVEPAAI----MEKV------- 130

  Fly   191 DYSKGFGGKFGVQEDRKDKSAVGWDHKEAPQKHASQVDHKVKPV--IEGAKPSNLRAKFENLAKN 253
              :||.|..:.:..:....     :|.|.|.:..| |..||..:  |:|....|..|:.|...||
Zfish   131 --AKGSGVNYNIHRESSQN-----NHSEPPGRVGS-VYKKVSALDEIQGTSRDNFWAQAERDEKN 187

  Fly   254 SEEESRKRAEEQKRLREAKDKRDRE--EA--------------------AKKTVAENTPRTSTEA 296
            ..:|.|::|:|: |.|..|::||:|  ||                    .||..|||     .|.
Zfish   188 RRQEERRKADEE-RQRLEKERRDQESREAEERERRRKEREKEIDQQRIFEKKLEAEN-----KEE 246

  Fly   297 PPPKGSRAAIQTGRTGGI--GNAISAFNQMQSPVSETPPARKEPIIIPKAQPVKIELEAKEEPTA 359
            ...|..:...||....||  ..::...|:..|.:|:....       |:...:|.|.....:.|:
Zfish   247 EQRKLEKEQQQTPVKAGILRSASVQKANEAASIISQRSTN-------PRELFMKKERSLVNDATS 304

  Fly   360 STTSAAVAPTPTVVPAREPETAPVAKAAAPPPDVVPQIEVETVDTP--PRSEPQSPVYVPTPQPE 422
            |.:|           :|:.:...            |.:..:.|.||  .||:|.||:........
Zfish   305 SPSS-----------SRQGQLRS------------PFLSQQAVSTPSESRSQPLSPLQPVASVSH 346

  Fly   423 VHAQV----QVQPEPQPQADPEPVVEEEPLYQNQAE----------IKAASPLP----------- 462
            |.|:|    :.|..|...|||   ..::|....|||          .:.:||..
Zfish   347 VPAKVSPVRETQTFPVKTADP---FSDDPFVSEQAEDYDDEWDDSDAEVSSPAATHKQNADGNST 408

  Fly   463 ----PTNGTVSEAVAPSGTATVPEEAIYANSDNLADYLEDTGIHAIALYDYQAADDDEISFDPDD 523
                |:|.::.|.|.....:...||   .|.||       ..|.|.|||||||:||.||||||||
Zfish   409 YMNIPSNQSLYENVHQDFQSPADEE---ENGDN-------QNICARALYDYQASDDTEISFDPDD 463

  Fly   524 VITHIEKIDDGWWRGLCKN-RYGLFPANYVQVV 555
            ||:.|:.||:|||||...: .||:||||||:::
Zfish   464 VISGIDMIDEGWWRGYGPDGHYGMFPANYVELM 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cortactin	NP_001247222.1	HS1_rep	84..119	CDD:396686
		HS1_rep	121..156	CDD:396686	8/28 (29%)
		HS1_rep	158..193	CDD:396686	8/35 (23%)
		HS1_rep	195..229	CDD:396686	7/33 (21%)
		rne	<327..489	CDD:236766	37/192 (19%)
		SH3_Cortactin	502..554	CDD:212892	36/52 (69%)
dbnla	NP_001002201.1	ADF_drebrin_like	3..135	CDD:200437	18/70 (26%)
		Cgr1	<180..>205	CDD:281823	9/25 (36%)
		SH3_Abp1_eu	442..495	CDD:212893	36/52 (69%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910