Protein Alignment Cortactin and Abp1

DIOPT Version :10

• Sequence 1: NP_524426.2
• Gene: Cortactin / 42491
• FlyBaseID: FBgn0025865
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_648657.1
• Gene: Abp1 / 39520
• FlyBaseID: FBgn0036372
• Length: 531
• Species: Drosophila melanogaster
• Alignment Length: 563
• Identity: 143/563 - (25%)
• Similarity: 228/563 - (40%)
• Gaps: 160/563 - (28%)

  Fly    25 TDPDFVNDVSEQEQRWGSKTIDGSGRTAGTIDMDKLREETEQADLDKKKQLLKDQNAGYGYGGKF 89
            |..:.:.||        |..:.|:..|....:.|.:       |||:..:.|...::.|.:....
  Fly    96 TCANHIRDV--------SNLLSGAHLTINARNEDDI-------DLDRLLKKLSTVSSAYSFKEPR 145

  Fly    90 GVEKDRMDKSAVGHDYQGKVGKHASQKDYSDGFGGKFGVQEDRKDKSAVGWDHVEKVEKHASQKD 154
            |..:::  |:.||.:|...:    ..|:.:......|..:|:.:          ||:.:.|.:
  Fly   146 GAMEEQ--KAPVGTNYTRVI----PTKELNASVMQDFWKKEEAE----------EKLRQEAEK-- 192

  Fly   155 YATGFGGKFGVQSDRVDKSAVGWDHIEKVEKHESQKDYSKGFGGKFGVQEDRKDKSAVGWDHKE- 218
                       :|.|::        ::|:|:.                |..|::|     :|||
  Fly   193 -----------ESKRLE--------LQKLEQE----------------QRSREEK-----EHKER 217

  Fly   219 ------APQKHASQVDHKVKPVIEGAKPSNLRAKFENLAKNSEEESRKRAEEQKRLREAKDKRDR 277
                  ..:...:.|..|..|  :...|......|.|...::|           |:|:|:::..|
  Fly   218 EKLVISTTKLQPAHVPIKTSP--QPLSPEKTAPGFANNLTDAE-----------RMRQARNQEAR 269

  Fly   278 E------EAAKKTVAENTPRTSTEA-----PPPKGSRAAIQTGRTGGIGNAISAFNQMQ---SPV 328
            |      .|||....::|.....::     ||.|.:|        ..|...|:.|||.|   :||
  Fly   270 ELIGSRVGAAKAMFTKHTSEGQLQSKLNTQPPAKPAR--------NSIAQRINVFNQNQPQDAPV 326

  Fly   329 SETPPARKEPIIIPKAQPVKIELEAKEEPTASTTSAAVAPTPTVVPAREPETAPVAKAAAPPPDV 393
             .:||....|     |:|:.:|                ||.| ||||  |..||.|..||.....
  Fly   327 -PSPPRAASP-----AKPLPVE----------------APEP-VVPA--PAIAPAAPVAAEVVST 366

  Fly   394 VPQI-EVETVDTPP---RSEPQSPVYVPTPQPEVHAQVQVQPEPQPQADPEPVVEEEPLYQNQAE 454
            :.:: |.:.||..|   .||..|.:...........|.|...|.....:.:..|.:|    .:.|
  Fly   367 IAEVEESQPVDDLPLAHESEQFSTIKRSPHSKSNSLQSQSPDETTSSNETDTAVSQE----QEEE 427

  Fly   455 IKAASPLPPTNGTV--SEAVAPSGTATVPEEAI--YANSDNL--ADYLEDTGIHAIALYDYQAAD 513
            ::.     ..:.||  |::|..||.:|:...|:  ..|.|:.  .:.|.|.|..|.|||||||||
  Fly   428 VRT-----KVSVTVQQSQSVKSSGMSTLERNALTDLVNEDDFICQETLGDLGQRARALYDYQAAD 487

  Fly   514 DDEISFDPDDVITHIEKIDDGWWRGLCKN-RYGLFPANYVQVV 555
            :.||:|||.||||||::||:|||:||..: .|||||||||:::
  Fly   488 ETEITFDPGDVITHIDQIDEGWWQGLGPDGTYGLFPANYVEII 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cortactin	NP_524426.2	HS1_rep	84..119	CDD:460497	6/34 (18%)
		HS1_rep	121..156	CDD:460497	5/34 (15%)
		HS1_rep	158..193	CDD:460497	4/34 (12%)
		HS1_rep	195..230	CDD:460497	7/41 (17%)
		rne	<327..489	CDD:236766	42/169 (25%)
		SH3_Cortactin	502..554	CDD:212892	37/52 (71%)
Abp1	NP_648657.1	ADF_drebrin_like	3..138	CDD:200437	11/56 (20%)
		SH3_Abp1_eu	476..529	CDD:212893	37/52 (71%)