DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cortactin and HCLS1

DIOPT Version :9

Sequence 1:	NP_001247222.1	Gene:	Cortactin / 42491	FlyBaseID:	FBgn0025865	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_005326.3	Gene:	HCLS1 / 3059	HGNCID:	4844	Length:	486	Species:	Homo sapiens

Alignment Length:	567	Identity:	233/567 - (41%)
Similarity:	332/567 - (58%)	Gaps:	94/567 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWKASAGHQIQATSAASAEDDDWETDPDFVNDVSEQEQRWGSKTIDGSGRTAGTIDMDKLREE-T 64
            |||:..||.:..  :...:.|||:||||||||:||:|||||:|||:|||||. .|::.:||.: :
Human     1 MWKSVVGHDVSV--SVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTE-HINIHQLRNKVS 62

  Fly    65 EQADLDKKKQLLKDQNAGYGYGGKFGVEKDRMDKSAVGHDYQGKVGKHASQKDYSDGFGGKFGVQ 129
            |:.|:.:||::.....|.:||||:||||:||||||||||:|..:|.||:||.|.:.|||||:||:
Human    63 EEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGFGGKYGVE 127

  Fly   130 EDRKDKSAVGWDHVEKVEKHASQKDYATGFGGKFGVQSDRVDKSAVGWDHIEKVEKHESQKDYSK 194
            .||.||||||:|:..:||||.|||||:.||||::||:.|:.||:|:|:|:..:.||||||:||:|
Human   128 RDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAK 192

  Fly   195 GFGGKFGVQEDRKDKSAVGWDHKEAPQKHASQVDHKVKPVIEGAKPS--NLRAKFENLAKNSEEE 257
            ||||::|:|:||.||||||::..|||     ...:|....||.|...  .|:||||::|    ||
Human   193 GFGGQYGIQKDRVDKSAVGFNEMEAP-----TTAYKKTTPIEAASSGTRGLKAKFESMA----EE 248

  Fly   258 SRKRAEEQKRLREAKDKRDREEAAKKTVAENTPRTSTE-----APPPKGSRAAIQTGRTGGIGNA 317
            .|||.||:|..:.|:.:::|:...|::.....|..:.|     ||.||                .
Human   249 KRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPK----------------K 297

  Fly   318 ISAFNQMQSPVSETPPARKEPIIIPKAQPVKIELEAKEEPTASTTSAAVAPTPTVVPAREPETAP 382
            ||  ::...||...|.:..||:...:..||.:                       :|.|  :|.|
Human   298 IS--SEAWPPVGTPPSSESEPVRTSREHPVPL-----------------------LPIR--QTLP 335

  Fly   383 VAKAAAP--PPDVVPQIEVETVDTPPRSEPQSPVYVPTPQPEVHAQVQVQPEPQPQADPEPVVEE 445
            ......|  ||..:..::||          :.|||...|:||      .:|||:|:.|.|. |||
Human   336 EDNEEPPALPPRTLEGLQVE----------EEPVYEAEPEPE------PEPEPEPENDYED-VEE 383

  Fly   446 EPLYQNQAEIKA--ASPLPPTNGTVSEAVAPSGTATVPEEAIYANSDNLADYLEDTGIHAIALYD 508
            ...::.:.|.:.  ...|.|.:.:.|.|:|  |::..|..   |.:..:|     .||.|:|:||
Human   384 MDRHEQEDEPEGDYEEVLEPEDSSFSSALA--GSSGCPAG---AGAGAVA-----LGISAVAVYD 438

  Fly   509 YQAADDDEISFDPDDVITHIEKIDDGWWRGLCKNRYGLFPANYVQVV 555
            ||....||:|||||||||.||.:|:|||||.|...:||||||||:::
Human   439 YQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cortactin	NP_001247222.1	HS1_rep	84..119	CDD:396686	25/34 (74%)
		HS1_rep	121..156	CDD:396686	24/34 (71%)
		HS1_rep	158..193	CDD:396686	19/34 (56%)
		HS1_rep	195..229	CDD:396686	17/33 (52%)
		rne	<327..489	CDD:236766	40/165 (24%)
		SH3_Cortactin	502..554	CDD:212892	34/51 (67%)
HCLS1	NP_005326.3	Involved in HAX-1 binding	27..66		23/39 (59%)
		Cortactin 1	79..115		25/35 (71%)
		HS1_rep	82..117	CDD:308050	25/34 (74%)
		Cortactin 2	116..152		22/35 (63%)
		HS1_rep	119..154	CDD:308050	24/34 (71%)
		Cortactin 3	153..189		19/35 (54%)
		HS1_rep	156..191	CDD:308050	19/34 (56%)
		Cortactin 4, truncated	190..212		15/21 (71%)
		HS1_rep	193..>218	CDD:308050	15/24 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..419		59/241 (24%)
		GGN	259..>348	CDD:330621	25/131 (19%)
		SH3_HS1	431..485	CDD:213006	35/53 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8435
eggNOG	1	0.900	-	-		E1_28JSJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	391	1.000	Inparanoid score	I2001
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1243441at2759
OrthoFinder	1	1.000	-	-		FOG0004044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105161
Panther	1	1.100	-	-	LDO	PTHR10829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5379
SonicParanoid	1	1.000	-	-		X2789
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860