DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cortactin and Hcls1

DIOPT Version :9

Sequence 1:	NP_001247222.1	Gene:	Cortactin / 42491	FlyBaseID:	FBgn0025865	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001011898.1	Gene:	Hcls1 / 288077	RGDID:	1304754	Length:	476	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	235/565 - (41%)
Similarity:	331/565 - (58%)	Gaps:	99/565 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWKASAGHQIQATSAASAEDDDWETDPDFVNDVSEQEQRWGSKTIDGSGRTAGTIDMDKLREE-T 64
            |||:..||.:..  :...:.|||:||||||||:||:|||||:|||:|||||. .|::.:||.: :
  Rat     1 MWKSVVGHNVSV--SVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTE-HINIHQLRNKVS 62

  Fly    65 EQADLDKKKQLLKDQNAGYGYGGKFGVEKDRMDKSAVGHDYQGKVGKHASQKDYSDGFGGKFGVQ 129
            |:.|:.||::|.....|.:||||:||||:||||||||||:|..:|.||:||.|.:.|||||:||:
  Rat    63 EEHDILKKRELESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGFGGKYGVE 127

  Fly   130 EDRKDKSAVGWDHVEKVEKHASQKDYATGFGGKFGVQSDRVDKSAVGWDHIEKVEKHESQKDYSK 194
            .||.||||||:|:..:||||||||||:.||||::||:.|:.||:|:|:|:..:.||||||:||:|
  Rat   128 RDRADKSAVGFDYKGEVEKHASQKDYSHGFGGRYGVEKDKRDKAALGYDYKGETEKHESQRDYAK 192

  Fly   195 GFGGKFGVQEDRKDKSAVGWDHKEAPQKHASQVDHKVKPVIEGAKPS--NLRAKFENLAKNSEEE 257
            ||||::|:|:||.||||||::..|||     ...:|....||.|...  .|:||||::|    ||
  Rat   193 GFGGQYGIQKDRVDKSAVGFNEMEAP-----TTAYKKTTPIEAASSGARGLKAKFESMA----EE 248

  Fly   258 SRKRAEEQKRLREAKDKRDRE-------EAAKKTVAENTPRTSTEAPPPKGSRAAIQTGRTGGIG 315
            .|||.||:|..:.|:.:::|:       ||.:.:|..:.|  :..||.||
  Rat   249 KRKREEEEKAQQMARQQQERKAMVKMSREAQQPSVPVDEP--AAPAPLPK--------------- 296

  Fly   316 NAISAFNQMQSPVSETPPARKEPIIIPKAQPVKIELEAKEEPTASTTSAAVAPTPTVVPAREPET 380
                   ::.|.|  .|||  |..:.|:::||....|              .|.|: :|.|:|.
  Rat   297 -------KISSEV--WPPA--ESHLPPQSEPVGGRRE--------------YPVPS-LPTRQPP- 334

  Fly   381 APVAKAAAPPPDVVPQIEVETVDTPPRSEPQSPVYVPTPQPEVHAQVQVQPEPQPQADPEPVVEE 445
                          ||..:|..:.||...|::|           ..:||..||..:|.|||..|.
  Rat   335 --------------PQNPLEDNEEPPALPPRTP-----------EGLQVVEEPVYEAAPEPEPEP 374

  Fly   446 EPLYQNQAEIKAASPLPPTNGTVSEAVAPSGTATVPEEAIYANSDNLADYLEDTGIHAIALYDYQ 510
            ||.|::..|:.  .|.....|...:.:.|..|.::..:|.::.....|      ||.|:||||||
  Rat   375 EPDYEDVGELD--RPDEEAEGDYEDVLEPEDTPSLSYQAGHSAGAGGA------GISAVALYDYQ 431

  Fly   511 AADDDEISFDPDDVITHIEKIDDGWWRGLCKNRYGLFPANYVQVV 555
            ....||:|||||||||.||.:|:|||||.|...:||||||||:::
  Rat   432 GEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLL 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cortactin	NP_001247222.1	HS1_rep	84..119	CDD:396686	25/34 (74%)
		HS1_rep	121..156	CDD:396686	25/34 (74%)
		HS1_rep	158..193	CDD:396686	19/34 (56%)
		HS1_rep	195..229	CDD:396686	17/33 (52%)
		rne	<327..489	CDD:236766	39/161 (24%)
		SH3_Cortactin	502..554	CDD:212892	35/51 (69%)
Hcls1	NP_001011898.1	HS1_rep	82..117	CDD:396686	25/34 (74%)
		HS1_rep	119..154	CDD:396686	25/34 (74%)
		HS1_rep	156..191	CDD:396686	19/34 (56%)
		HS1_rep	193..>216	CDD:396686	14/22 (64%)
		tatB	<263..353	CDD:166942	30/147 (20%)
		SH3	425..476	CDD:418401	34/50 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8163
eggNOG	1	0.900	-	-		E1_28JSJ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1918
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1243441at2759
OrthoFinder	1	1.000	-	-		FOG0004044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105161
Panther	1	1.100	-	-	LDO	PTHR10829
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2789
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.830