Protein Alignment Cortactin and abp1

DIOPT Version :9

• Sequence 1: NP_001247222.1
• Gene: Cortactin / 42491
• FlyBaseID: FBgn0025865
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_594921.1
• Gene: abp1 / 2542979
• PomBaseID: SPAPJ760.02c
• Length: 857
• Species: Schizosaccharomyces pombe
• Alignment Length: 793
• Identity: 174/793 - (21%)
• Similarity: 240/793 - (30%)
• Gaps: 336/793 - (42%)

  Fly    48 SGRTAGTIDMDKLREETEQADLDKKKQLLKDQNAGYGYGGKFGVEKDRMDKSAVGHDYQGKVGKH 112
            :||.:..::||.:......|.                 |.|:.|........:          ||
pombe   116 TGRESSDLNMDDIIRRVADAS-----------------GSKYSVHTSNSTPQS----------KH 153

  Fly   113 ASQKDYSDGFGGKFGV----------------------QEDRKDKSAVGWDHVEKVEKHASQKDY 155
            .:..|.|..||....|                      |:|.||.|   ||...|      |.:.
pombe   154 NAFYDASQTFGSTAKVAPAPAPSTKTPLANISKPVVQAQKDSKDNS---WDDSSK------QSNT 209

  Fly   156 ATGFGGKFGVQSD-RVDKSAVGWDHIEKVEKHESQKDYSKGFGG----------------KFGVQ 203
            .|.     ...|: ||..:| .|....:.||.:..|.....||.                :..||
pombe   210 QTA-----NTTSNLRVPVNA-SWSDAGRKEKSQENKPKPTPFGSGGPSKPTPFESHGPAKQISVQ 268

  Fly   204 EDRKDKSAV-----GWDHKEAPQKHA-SQVDH-------KVKPVIEGAKPS-------------- 241
            .....|.::     |..::.|...|| :..||       |::|......||
pombe   269 PSEHPKPSISTTTTGSSYRSAESSHAPTTPDHFKLTPLTKLEPQPPSGSPSKKPVSELEELHTAG 333

  Fly   242 --NL---RAKFENLAKNSEEESRKRAEE---------------------QKRLREAKDKRDREEA 280
              ||   ||.||     .:|.|.|..|.                     .|:...:....|::|.
pombe   334 NVNLSARRALFE-----KKESSTKNVENPVSHHLKSPVRTSFPPASTTASKQDSPSTVPVDKQET 393

  Fly   281 AK---------KTVAENTPRTSTEA---------------PP--PK--------GSRAAIQTGRT 311
            ||         :|.|:..||.|..|               ||  ||        .|:|.....:.
pombe   394 AKPINKQVSSNETSAQEEPRESVAALRARFAKANVSENNDPPTFPKTAAKISSFNSKAGTSFAKP 458

  Fly   312 GGIGNAISAFNQMQSPVS------ETPPA----------------RKEPIII------PKAQPVK 348
            ....|..:..:..:.|.|      ..|||                ..:|.:|      |.|.||.
pombe   459 RPFTNNPNPISAPEKPTSGESLSLNPPPAMPKVFPERDISSASQKAAQPSVITPSVPQPPAAPVV 523

  Fly   349 IELEAKEEPTASTT-----------SAAVAPTPTVVPAR-------------EPETAPVAK--AA 387
            .|..:..:|.|:..           :|.|.|....||.|             :|..||||.  .:
pombe   524 PEAPSVHQPPAAPVAPEVPSAPQRPAAPVVPEAPSVPQRPAVPVVPEALSVPQPPVAPVAPEVPS 588

  Fly   388 APPPDVVPQI-EVETVDTPP--------RSEPQSPVY--------VPTPQ-----PEV-----HA 425
            .|.|.|.|.: |..:|..||        .|.||.|..        ||.|.     |||     ..
pombe   589 VPQPPVAPVVPEAPSVPQPPVAPVAPEVPSVPQRPAVPVVPEAPSVPQPPAAPVVPEVPSVPQRP 653

  Fly   426 QVQVQPE----PQPQADP-------------EPVVEEEPLYQNQAEIKAASPLPPTNGT------ 467
            .|.|.||    |||.|.|             .|||.|    ..|.......||||.:.|
pombe   654 AVPVVPEAPSVPQPPAAPVVPEVPSVPQPPAVPVVPE----AGQLNEPVVPPLPPHDETQEPQVG 714

  Fly   468 ----VSEAVAPSGTATV------PEEA----------------------IYANSDNL-----ADY 495
                .:|...|:.|..:      |||.                      :..||...     ::|
pombe   715 GDVKATEHTQPTKTPAIVIYDYSPEEENEIELVENEQIQILEFVDDGWWLGENSKGQQGLFPSNY 779

  Fly   496 LEDTGIHAI------------------ALYDYQAADDDEISFDPDDVITHIEKIDDGWWRGLCKN 542
            :|.||.:..                  |:|||||.:|:|:||..|::|.:::.:|..||.|.|..
pombe   780 VEITGPNETANNPPAEPQAGGPGKSVKAIYDYQAQEDNELSFFEDEIIANVDCVDPNWWEGECHG 844

  Fly   543 RYGLFPANYVQVV 555
            ..||||:|||:.:
pombe   845 HRGLFPSNYVEEI 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cortactin	NP_001247222.1	HS1_rep	84..119	CDD:396686	6/34 (18%)
		HS1_rep	121..156	CDD:396686	12/56 (21%)
		HS1_rep	158..193	CDD:396686	8/35 (23%)
		HS1_rep	195..229	CDD:396686	9/55 (16%)
		rne	<327..489	CDD:236766	68/297 (23%)
		SH3_Cortactin	502..554	CDD:212892	24/69 (35%)
abp1	NP_594921.1	ADF_drebrin_like	5..138	CDD:200437	5/38 (13%)
		SH3	729..782	CDD:302595	6/52 (12%)
		SH3_Abp1_fungi_C2	804..856	CDD:212894	24/51 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	65	1.000	Domainoid score	I2835
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10829
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	3.060