DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cortactin and Hcls1

DIOPT Version :10

Sequence 1:NP_524426.2 Gene:Cortactin / 42491 FlyBaseID:FBgn0025865 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_032251.2 Gene:Hcls1 / 15163 MGIID:104568 Length:486 Species:Mus musculus


Alignment Length:559 Identity:233/559 - (41%)
Similarity:334/559 - (59%) Gaps:77/559 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MWKASAGHQIQATSAASAEDDDWETDPDFVNDVSEQEQRWGSKTIDGSGRTAGTIDMDKLREE-T 64
            |||:..||.:..  :...:.|||:||||||||:||:|||||:|||:|||||. .|::.:||.: :
Mouse     1 MWKSVVGHDVSV--SVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTE-HINIHQLRNKVS 62

  Fly    65 EQADLDKKKQLLKDQNAGYGYGGKFGVEKDRMDKSAVGHDYQGKVGKHASQKDYSDGFGGKFGVQ 129
            |:.|:.|||:|.....|.:||||:||||:||||||||||:|...|.||:||.|.:.|||||:||:
Mouse    63 EEHDILKKKELESGPKASHGYGGRFGVERDRMDKSAVGHEYVADVEKHSSQTDAARGFGGKYGVE 127

  Fly   130 EDRKDKSAVGWDHVEKVEKHASQKDYATGFGGKFGVQSDRVDKSAVGWDHIEKVEKHESQKDYSK 194
            .||.||||||:|:..:||||||||||:.||||::||:.|:.||:|:|:|:..:.||||||:||:|
Mouse   128 RDRADKSAVGFDYKGEVEKHASQKDYSHGFGGRYGVEKDKRDKAALGYDYKGETEKHESQRDYAK 192

  Fly   195 GFGGKFGVQEDRKDKSAVGWDHKEAPQKHASQVDHKVKPVIEGAKPSNLRAKFENLAKNSEEESR 259
            ||||::|:|:||.||||||::..|||.. |.:....::....||:  .|:||||:||    ||.|
Mouse   193 GFGGQYGIQKDRVDKSAVGFNEMEAPTT-AYKKTTPIEAASSGAR--GLKAKFESLA----EEKR 250

  Fly   260 KRAEEQKRLREAKDKRDREEAAKKTVAENTPRTSTEAPPPKGSRAAIQTGRTGGIGNAISAFNQM 324
            ||.||:|..:.|:.:::|:...|.:.....|....|.|                     :|..|:
Mouse   251 KREEEEKAQQMARQQQERKAVVKMSREVQQPSMPVEEP---------------------AAPAQL 294

  Fly   325 QSPVSET--PPARKEPIIIPKAQPVKIELEAKEEPTASTTSAAVAPTPTVVPAREPETAPVAKAA 387
            ...:|..  |||  |..:.|::|||:...|              .|.|: :|.|:   :|:    
Mouse   295 PKKISSEVWPPA--ESHLPPESQPVRSRRE--------------YPVPS-LPTRQ---SPL---- 335

  Fly   388 APPPDVVPQIEVETVDTPPRSEPQSPVYVP-TPQPEVHAQVQVQPEPQPQADPEPVVEEEPLYQN 451
                    |..:|..:.||...|::|..:. ..:|...|..:::|||:|..:|||  |.||.|::
Mouse   336 --------QNHLEDNEEPPALPPRTPEGLQVVEEPVYEAAPELEPEPEPDYEPEP--ETEPDYED 390

  Fly   452 QAEIKAASPLPPTNGTVSEAVAPSGTATVPEEAIYANSDNLADYLEDTGIHAIALYDYQAADDDE 516
            ..|:....  ....|...:.:.|..|.::..:|..:.....|      ||.||||||||....||
Mouse   391 VGELDRQD--EDAEGDYEDVLEPEDTPSLSYQAGPSAGAGGA------GISAIALYDYQGEGSDE 447

  Fly   517 ISFDPDDVITHIEKIDDGWWRGLCKNRYGLFPANYVQVV 555
            :||||||:||.||.:|:|||||.|:..:||||||||:::
Mouse   448 LSFDPDDIITDIEMVDEGWWRGQCRGHFGLFPANYVKLL 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CortactinNP_524426.2 HS1_rep 84..119 CDD:460497 25/34 (74%)
HS1_rep 121..156 CDD:460497 25/34 (74%)
HS1_rep 158..193 CDD:460497 19/34 (56%)
HS1_rep 195..230 CDD:460497 18/34 (53%)
rne <327..489 CDD:236766 39/164 (24%)
SH3_Cortactin 502..554 CDD:212892 35/51 (69%)
Hcls1NP_032251.2 Involved in HAX-1 binding. /evidence=ECO:0000250 27..66 23/39 (59%)
Cortactin 1 79..115 25/35 (71%)
HS1_rep 82..117 CDD:460497 25/34 (74%)
Cortactin 2 116..152 23/35 (66%)
HS1_rep 119..154 CDD:460497 25/34 (74%)
Cortactin 3 153..189 19/35 (54%)
HS1_rep 156..191 CDD:460497 19/34 (56%)
Cortactin 4, truncated 190..212 15/21 (71%)
HS1_rep 193..>218 CDD:460497 15/24 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..430 64/266 (24%)
SH3 437..485 CDD:473055 32/47 (68%)

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