DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cortactin and Hcls1

DIOPT Version :9

Sequence 1:NP_001247222.1 Gene:Cortactin / 42491 FlyBaseID:FBgn0025865 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_032251.2 Gene:Hcls1 / 15163 MGIID:104568 Length:486 Species:Mus musculus


Alignment Length:561 Identity:234/561 - (41%)
Similarity:332/561 - (59%) Gaps:81/561 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MWKASAGHQIQATSAASAEDDDWETDPDFVNDVSEQEQRWGSKTIDGSGRTAGTIDMDKLREE-T 64
            |||:..||.:..  :...:.|||:||||||||:||:|||||:|||:|||||. .|::.:||.: :
Mouse     1 MWKSVVGHDVSV--SVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTE-HINIHQLRNKVS 62

  Fly    65 EQADLDKKKQLLKDQNAGYGYGGKFGVEKDRMDKSAVGHDYQGKVGKHASQKDYSDGFGGKFGVQ 129
            |:.|:.|||:|.....|.:||||:||||:||||||||||:|...|.||:||.|.:.|||||:||:
Mouse    63 EEHDILKKKELESGPKASHGYGGRFGVERDRMDKSAVGHEYVADVEKHSSQTDAARGFGGKYGVE 127

  Fly   130 EDRKDKSAVGWDHVEKVEKHASQKDYATGFGGKFGVQSDRVDKSAVGWDHIEKVEKHESQKDYSK 194
            .||.||||||:|:..:||||||||||:.||||::||:.|:.||:|:|:|:..:.||||||:||:|
Mouse   128 RDRADKSAVGFDYKGEVEKHASQKDYSHGFGGRYGVEKDKRDKAALGYDYKGETEKHESQRDYAK 192

  Fly   195 GFGGKFGVQEDRKDKSAVGWDHKEAPQKHASQVDHKVKPVIEGAKPS--NLRAKFENLAKNSEEE 257
            ||||::|:|:||.||||||::..|||     ...:|....||.|...  .|:||||:||    ||
Mouse   193 GFGGQYGIQKDRVDKSAVGFNEMEAP-----TTAYKKTTPIEAASSGARGLKAKFESLA----EE 248

  Fly   258 SRKRAEEQKRLREAKDKRDREEAAKKTVAENTPRTSTEAPPPKGSRAAIQTGRTGGIGNAISAFN 322
            .|||.||:|..:.|:.:::|:...|.:.....|....|.|                     :|..
Mouse   249 KRKREEEEKAQQMARQQQERKAVVKMSREVQQPSMPVEEP---------------------AAPA 292

  Fly   323 QMQSPVSET--PPARKEPIIIPKAQPVKIELEAKEEPTASTTSAAVAPTPTVVPAREPETAPVAK 385
            |:...:|..  |||  |..:.|::|||:...|              .|.|: :|.|:   :|:  
Mouse   293 QLPKKISSEVWPPA--ESHLPPESQPVRSRRE--------------YPVPS-LPTRQ---SPL-- 335

  Fly   386 AAAPPPDVVPQIEVETVDTPPRSEPQSPVYVP-TPQPEVHAQVQVQPEPQPQADPEPVVEEEPLY 449
                      |..:|..:.||...|::|..:. ..:|...|..:::|||:|..:|||  |.||.|
Mouse   336 ----------QNHLEDNEEPPALPPRTPEGLQVVEEPVYEAAPELEPEPEPDYEPEP--ETEPDY 388

  Fly   450 QNQAEIKAASPLPPTNGTVSEAVAPSGTATVPEEAIYANSDNLADYLEDTGIHAIALYDYQAADD 514
            ::..|:....  ....|...:.:.|..|.::..:|..:.....|      ||.||||||||....
Mouse   389 EDVGELDRQD--EDAEGDYEDVLEPEDTPSLSYQAGPSAGAGGA------GISAIALYDYQGEGS 445

  Fly   515 DEISFDPDDVITHIEKIDDGWWRGLCKNRYGLFPANYVQVV 555
            ||:||||||:||.||.:|:|||||.|:..:||||||||:::
Mouse   446 DELSFDPDDIITDIEMVDEGWWRGQCRGHFGLFPANYVKLL 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CortactinNP_001247222.1 HS1_rep 84..119 CDD:396686 25/34 (74%)
HS1_rep 121..156 CDD:396686 25/34 (74%)
HS1_rep 158..193 CDD:396686 19/34 (56%)
HS1_rep 195..229 CDD:396686 17/33 (52%)
rne <327..489 CDD:236766 39/164 (24%)
SH3_Cortactin 502..554 CDD:212892 35/51 (69%)
Hcls1NP_032251.2 Involved in HAX-1 binding. /evidence=ECO:0000250 27..66 23/39 (59%)
Cortactin 1 79..115 25/35 (71%)
HS1_rep 82..117 CDD:280396 25/34 (74%)
Cortactin 2 116..152 23/35 (66%)
HS1_rep 119..154 CDD:280396 25/34 (74%)
Cortactin 3 153..189 19/35 (54%)
HS1_rep 156..191 CDD:280396 19/34 (56%)
Cortactin 4, truncated 190..212 15/21 (71%)
HS1_rep 193..>218 CDD:280396 15/24 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..430 65/264 (25%)
SH3 437..485 CDD:302595 32/47 (68%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 84 1.000 Domainoid score I8246
eggNOG 1 0.900 - - E1_28JSJ
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 399 1.000 Inparanoid score I1927
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1243441at2759
OrthoFinder 1 1.000 - - FOG0004044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_105161
Panther 1 1.100 - - LDO PTHR10829
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5379
SonicParanoid 1 1.000 - - X2789
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.860

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