Protein Alignment Cortactin and Dbnl

DIOPT Version :10

• Sequence 1: NP_524426.2
• Gene: Cortactin / 42491
• FlyBaseID: FBgn0025865
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_001139780.1
• Gene: Dbnl / 13169
• MGIID: 700006
• Length: 436
• Species: Mus musculus
• Alignment Length: 550
• Identity: 141/550 - (25%)
• Similarity: 217/550 - (39%)
• Gaps: 153/550 - (27%)

  Fly    29 FVNDVSEQEQR-WGSKTIDGSG---RTAGTID--MDKLREETEQADLDKKKQLLKDQNAGYGYGG 87
            :|..|:|:... |...|.:|:.   |.|||.:  :::|.||.....:......:||.|:|.   .
Mouse    16 YVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEELVEELNSGKVMYAFCRVKDPNSGL---P 77

  Fly    88 KFGVEKDRMDKSAVGHDYQGKVGKHASQKDYSDGFGGKFGVQEDRKDKSAVGWDHVEKVEKHASQ 152
            ||           |..::.|:                  ||.:.||...|   :||      ::.
Mouse    78 KF-----------VLINWTGE------------------GVNDVRKGACA---NHV------STM 104

  Fly   153 KDYATGFGGKFGVQSDRVDKSAVGWDHIEKVEKHESQKDYSKGFGGKFGVQEDRKDKSAVGWDHK 217
            .::..|.......:::            |.||.....:..:|..|..:...::......||
Mouse   105 ANFLKGAHVTINARAE------------EDVEPECIMEKVAKASGANYSFHKESTSFQDVG---- 153

  Fly   218 EAPQKHASQVDHKVKPV--IEGAKPSNLRAKFENLAKNSEEESRKRAEEQK-RLREAKDKRDREE 279
              ||.....|..|...:  |:.....|..||.|...:|...|.::||||:: ||.|.:.:|:.:|
Mouse   154 --PQAPVGSVYQKTNAISEIKRVGKDNFWAKAEKEEENRRLEEKRRAEEERQRLEEERRERELQE 216

  Fly   280 AAKKTVAENTPRTSTEAPPPKGSRAAIQTGRTGGIGNAISAFNQMQSPVSETPPARKEPIIIPKA 344
            ||::.........|..||.|        :.|||         ...|..||.|   |:|.....:.
Mouse   217 AARREQRYQEQHRSAGAPSP--------SSRTG---------EPEQEAVSRT---RQEWESAGQQ 261

  Fly   345 QPVKIELEAKEEPTASTTSAAVAPTPTVVPAREPETAPVAKAAAPPPDVVPQIEVETVDTPPRSE 409
            .|...|:..::|...||||         |.:.:|     .|..:|    ..|.::...:|....|
Mouse   262 APHPREIFKQKERAMSTTS---------VTSSQP-----GKLRSP----FLQKQLTQPETSYGRE 308

  Fly   410 PQSPVYVPT------PQPEVHAQVQVQPEPQPQADPE--PVVEEEPLYQNQAEIKAASPLPPTNG 466
            |.:||..|.      |.|...:..|.:.||..:..||  .:.||.||.|.|.
Mouse   309 PTAPVSRPAAGVCEEPAPSTLSSAQTEEEPTYEVPPEQDTLYEEPPLVQQQG------------- 360

  Fly   467 TVSEAVAPSGTATVPEEAIYANSDNLADYLED-----TGIHAIALYDYQAADDDEISFDPDDVIT 526
                                |.|:::.:|::.     .|:.|.||||||||||.||||||:::||
Mouse   361 --------------------AGSEHIDNYMQSQGFSGQGLCARALYDYQAADDTEISFDPENLIT 405

  Fly   527 HIEKIDDGWWRGLCKN-RYGLFPANYVQVV 555
            .||.||:|||||...: .:|:||||||:::
Mouse   406 GIEVIDEGWWRGYGPDGHFGMFPANYVELI 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cortactin	NP_524426.2	HS1_rep	84..119	CDD:460497	4/34 (12%)
		HS1_rep	121..156	CDD:460497	7/34 (21%)
		HS1_rep	158..193	CDD:460497	4/34 (12%)
		HS1_rep	195..230	CDD:460497	6/34 (18%)
		rne	<327..489	CDD:236766	37/169 (22%)
		SH3_Cortactin	502..554	CDD:212892	35/52 (67%)
Dbnl	NP_001139780.1	ADF_drebrin_like	3..138	CDD:200437	33/174 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	185..341		49/193 (25%)
		PRK13335	238..>341	CDD:139494	32/132 (24%)
		SH3_Abp1_eu	381..434	CDD:212893	35/52 (67%)