Protein Alignment Cortactin and Cttn

DIOPT Version :10

• Sequence 1: NP_524426.2
• Gene: Cortactin / 42491
• FlyBaseID: FBgn0025865
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_031829.2
• Gene: Cttn / 13043
• MGIID: 99695
• Length: 546
• Species: Mus musculus
• Alignment Length: 666
• Identity: 254/666 - (38%)
• Similarity: 310/666 - (46%)
• Gaps: 234/666 - (35%)

  Fly     1 MWKASAGHQIQATSAASAED---DDWETDPDFVNDVSEQEQRWGSKTIDGSGRTAGTIDMDKLRE 62
            ||||||||.:..|.    :|   |||||||||||||||:|||||:||:.|||... .|::.||||
Mouse     1 MWKASAGHAVSITQ----DDGGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQE-HINIHKLRE 60

  Fly    63 ET-EQADLDKKKQLLKDQNAGYGYGGKFGVEKDRMDKSAVGH----------------------- 103
            .. ::....|:|:|.....|.:|||||||||:||||:|||||
Mouse    61 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDRSAVGHEYQSKLSKHCSQVDSVRGFGGKF 125

  Fly   104 --------------DYQGKVGKHASQKDYSDGFGGKFGVQEDRKDKSAVGWDHVEKVEKHASQKD 154
                          :||||..|||||||||.|||||:|||.||.||||||:|:..|.|||.||||
Mouse   126 GVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQKD 190

  Fly   155 YATGFGGKFGVQSDRVDKSAVGWDHIEKVEKHESQKDYSKGFGGKFGVQEDRKDKSAVGWDHKEA 219
            |:.|||||:|:..|:|||||||:::..|.|||||||||.||||||||||.||:||.|:||||:|.
Mouse   191 YSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEK 255

  Fly   220 PQKHASQVDHKV----------------------------------------------------- 231
            .|.|.||.|:|.
Mouse   256 LQLHESQKDYKTGFGGKFGVQSERQDSSAVGFDYKERLAKHESQQDYAKGFGGKYGVQKDRMDKN 320

  Fly   232 ---------------KPV-IEG--AKPSNLRAKFENLAKNSEEESRKRAEEQKRLREAKDKRDRE 278
                           |.| ||.  :|.||:||.||||||..|:|.|::||.::..|.||:::::|
Mouse   321 ASTFEEVVQVPSAYQKTVPIEAVTSKTSNIRANFENLAKEREQEDRRKAEAERAQRMAKERQEQE 385

  Fly   279 EAAKKTVAENTPRTSTEAPPPKGSRAAIQTGRTGGIGNAISAFNQMQSPVSETPPARKEPIIIPK 343
            ||.:|  .|...|...:.||...|                      ..|:.:.||:..   |...
Mouse   386 EARRK--LEEQARAKKQTPPASPS----------------------PQPIEDRPPSSP---IYED 423

  Fly   344 AQPVKIELEAKEEPTASTTSAAVAPTPTVVPAREPETAPVAKAAAPPPDVVPQIEVETVDTPPRS 408
            |.|.|.|...:                    ..|||               |:..:|....|...
Mouse   424 AAPFKAEPSYR--------------------GSEPE---------------PEYSIEAAGIPEAG 453

  Fly   409 EPQSPVYVPTPQPEVHAQVQVQPEPQPQADPEPVVEEEPLYQNQAEIKAASPLPPTNGTVSEAVA 473
            ..|...|.                            .||:|:
Mouse   454 SQQGLTYT----------------------------SEPVYE----------------------- 467

  Fly   474 PSGTATVPEEAIYANSDNLADYLEDTGIHAIALYDYQAADDDEISFDPDDVITHIEKIDDGWWRG 538
               |...|.. ..|..|....|..|.||.||||||||||.||||||||||:||:||.||||||||
Mouse   468 ---TTEAPGH-YQAEDDTYDGYESDLGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRG 528

  Fly   539 LCKNRYGLFPANYVQV 554
            :||.||||||||||::
Mouse   529 VCKGRYGLFPANYVEL 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cortactin	NP_524426.2	HS1_rep	84..119	CDD:460497	29/71 (41%)
		HS1_rep	121..156	CDD:460497	25/34 (74%)
		HS1_rep	158..193	CDD:460497	23/34 (68%)
		HS1_rep	195..230	CDD:460497	24/34 (71%)
		rne	<327..489	CDD:236766	22/161 (14%)
		SH3_Cortactin	502..554	CDD:212892	44/51 (86%)
Cttn	NP_031829.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		17/30 (57%)
		Cortactin 1	80..116		19/35 (54%)
		HS1_rep	83..116	CDD:460497	18/32 (56%)
		Cortactin 2	117..153		9/35 (26%)
		HS1_rep	120..155	CDD:460497	11/34 (32%)
		Cortactin 3	154..190		25/35 (71%)
		HS1_rep	157..192	CDD:460497	25/34 (74%)
		Cortactin 4	191..227		22/35 (63%)
		HS1_rep	194..228	CDD:460497	22/33 (67%)
		Cortactin 5	228..264		25/35 (71%)
		HS1_rep	231..266	CDD:460497	24/34 (71%)
		Cortactin 6	265..301		1/35 (3%)
		HS1_rep	268..303	CDD:460497	0/34 (0%)
		Cortactin 7, truncated	302..324		0/21 (0%)
		HS1_rep	305..>330	CDD:460497	0/24 (0%)
		PspC_subgroup_1	<325..>440	CDD:468201	43/176 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..424		26/95 (27%)
		Casc1_N	358..>400	CDD:464947	16/43 (37%)
		SH3_Cortactin	492..544	CDD:212892	44/51 (86%)