DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cortactin and cttn

DIOPT Version :9

Sequence 1:	NP_001247222.1	Gene:	Cortactin / 42491	FlyBaseID:	FBgn0025865	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_031755572.1	Gene:	cttn / 100038122	XenbaseID:	XB-GENE-492434	Length:	569	Species:	Xenopus tropicalis

Alignment Length:	669	Identity:	267/669 - (39%)
Similarity:	338/669 - (50%)	Gaps:	217/669 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWKASAGHQIQATSAASAEDDDWETDPDFVNDVSEQEQRWGSKTIDGSGRTAGTIDMDKLREETE 65
            |||::|||.:   |.::.|.||||||||||||::|:|||||:||::|||... .|::.||||:..
Frog     1 MWKSAAGHSL---SISTDETDDWETDPDFVNDINEKEQRWGAKTVEGSGHQE-HINIHKLREKVS 61

  Fly    66 QADLD-KKKQLLKDQNAGYGYGGKFGVEKDRMDKSAVGH-------------------------- 103
            ....: |:|:|.....|.:|||||||||||||||.||||
Frog    62 HEHQEIKEKELEIGPKASHGYGGKFGVEKDRMDKMAVGHEYQTKLSKHCSQLDATKGFGGKFGVQ 126

  Fly   104 -----------DYQGKVGKHASQKDYSDGFGGKFGVQEDRKDKSAVGWDHVEKVEKHASQKDYAT 157
                       ||:||..||||||||:.|||||:|||.||.||||.|:|:..|.|||.||.||.|
Frog   127 TDRVDQSAVNFDYKGKTEKHASQKDYATGFGGKYGVQADRVDKSAHGFDYKAKTEKHESQIDYTT 191

  Fly   158 GFGGKFGVQSDRVDKSAVGWDHIEKVEKHESQKDYS----------------------------- 193
            |||||||||:|||||||||:|:..|.||||||||||
Frog   192 GFGGKFGVQADRVDKSAVGYDYQGKTEKHESQKDYSKGFGGKYGVDKENVDKSALGFDYQGKTEK 256

  Fly   194 --------KGFGGKFGVQEDRKDKSAVGWDHKEAPQKHASQVDH--------------------- 229
                    ||||||||||.||:|..|:||||:|..|.|.||.|:
Frog   257 HESQKDYVKGFGGKFGVQTDRQDACALGWDHQEKLQLHESQKDYSKGFGGKYGVQKDRMDKAAAS 321

  Fly   230 ------------KVKPV-IEGAKPSNLRAKFENLAKNSEEESRKRAEEQKRLREAKDKRDREEAA 281
                        |.:|| :||:|.|::||.||||||:.|||.||:||.::..|..:::|::|:|.
Frog   322 FEDIEKVSSSYQKTRPVEVEGSKASSIRANFENLAKDKEEEDRKKAEAERAQRMERERREQEQAR 386

  Fly   282 KK--TVAENTPRTSTEAPPPKGSRAAIQTGRTGGIGNAISAFNQMQSPVSETPPARKEPIIIPKA 344
            ::  ..|::.|                                .:.||   .|.|...||:....
Frog   387 RRQEVGAQSVP--------------------------------SLWSP---GPTAASAPILPDTD 416

  Fly   345 QPVKIELEAKEEPTASTTSAAVAPTPTVVPAREPETAPVAKAAAPPPDVVPQIEVETVDTPPRSE 409
            .|:...|:.:|                               :|.||            |||.|
Frog   417 SPIVFSLQEQE-------------------------------SAKPP------------TPPAS- 437

  Fly   410 PQSPVYVPTPQPEVHAQVQVQPEPQPQADP---EPVVEEEPLYQNQAEIKAASPLPPTNGTVSEA 471
            |::|:.|  |:..::.....:.|.:|...|   |||..|||.||:....|.|:         .||
Frog   438 PKAPIKV--PESPIYEDATPEYESEPHRAPPVAEPVYAEEPDYQDAEMHKEAA---------QEA 491

  Fly   472 VAPSGTATVPEEAIYANSDNLAD-YLEDTGIHAIALYDYQAADDDEISFDPDDVITHIEKIDDGW 535
            |.        |.|.|..::|..| |.||.||.||||||||||.||||||||||:||:||.|||||
Frog   492 VY--------ESADYQEAENTYDEYNEDVGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDGW 548

  Fly   536 WRGLCKNRYGLFPANYVQV 554
            |||.||..|||||||||::
Frog   549 WRGFCKECYGLFPANYVEL 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cortactin	NP_001247222.1	HS1_rep	84..119	CDD:396686	30/71 (42%)
		HS1_rep	121..156	CDD:396686	23/34 (68%)
		HS1_rep	158..193	CDD:396686	28/34 (82%)
		HS1_rep	195..229	CDD:396686	22/33 (67%)
		rne	<327..489	CDD:236766	38/164 (23%)
		SH3_Cortactin	502..554	CDD:212892	43/51 (84%)
cttn	XP_031755572.1	HS1_rep	81..115	CDD:396686	19/33 (58%)
		HS1_rep	118..153	CDD:396686	11/34 (32%)
		HS1_rep	155..189	CDD:396686	22/33 (67%)
		HS1_rep	192..227	CDD:396686	28/34 (82%)
		HS1_rep	229..263	CDD:396686	0/33 (0%)
		HS1_rep	266..301	CDD:396686	23/34 (68%)
		HS1_rep	303..>329	CDD:396686	0/25 (0%)
		PRK10263	<394..>507	CDD:236669	41/210 (20%)
		SH3_Cortactin	515..567	CDD:212892	43/51 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7259
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3834
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1878
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1243441at2759
OrthoFinder	1	1.000	-	-		FOG0004044
OrthoInspector	1	1.000	-	-		otm47580
Panther	1	1.100	-	-	O	PTHR10829
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5379
SonicParanoid	1	1.000	-	-		X2789
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190