DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mvl and SMF2

DIOPT Version :9

Sequence 1:	NP_001262795.1	Gene:	Mvl / 42490	FlyBaseID:	FBgn0011672	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_011917.1	Gene:	SMF2 / 856447	SGDID:	S000001092	Length:	549	Species:	Saccharomyces cerevisiae

Alignment Length:	533	Identity:	146/533 - (27%)
Similarity:	244/533 - (45%)	Gaps:	119/533 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LIPDDDSTNVGFSFRKLWAFTGPGFLMSIAYLDPGNIESDMQSGAAAKYKILWVLLWATVLGLLM 125
            |.|:..|.::..:.||...|.|||.::|::|:||||..:.:.:|:|.:||:|:.:|.:..:....
Yeast    41 LQPNSTSQSMIGTLRKYARFIGPGLMVSVSYMDPGNYSTAVAAGSAHRYKLLFSVLVSNFMAAFW 105

  Fly   126 QRLAARLGVVTGLHLAEMCYRQYKRLPRWI---LWIMIEIAIIGSDMQEVIGTAIAIYLLSNKVV 187
            |.|.||||.||||.||:.|   .|.||..:   |:|:.|:|||.:|:.||:||||::.:|.:  :
Yeast   106 QYLCARLGAVTGLDLAQNC---KKHLPFGLNITLYILAEMAIIATDLAEVVGTAISLNILFH--I 165

  Fly   188 PLWGGVLITIVDTFTFLFLDK-----YGLRKLEFLFGTLITIMAVSFGYE--YIVSAPNQGEVLE 245
            ||..||::|:||....|...|     .|:|..|.....|:.:..|.|..|  |....|.: |:..
Yeast   166 PLALGVILTVVDVLIVLLAYKPNGSMKGIRIFEAFVSLLVVLTVVCFTVELFYAKLGPAK-EIFS 229

  Fly   246 GMFVPWCSNCNSNVLLQAVGVVGAVIMPHNLYLHSALVKSR----------------DID----- 289
            | |:|..:....:.|..::.::||.:|||:|||.|.:|:.|                |:|
Yeast   230 G-FLPSKAVFEGDGLYLSLAILGATVMPHSLYLGSGVVQPRLREYDIKNGHYLPDANDMDNNHDN 293

  Fly   290 -RRQTKKVSEANFYFFIEASVALF-VSFIINLFVVAVFAHGMYGKTNNDVVEVCKDKSMYEDAKM 352
             |...:.:||...:...|..::|| |:..:|..::.|....:||.|.|           .|:|.:
Yeast   294 YRPSYEAISETLHFTITELLISLFTVALFVNCAILIVSGATLYGSTQN-----------AEEADL 347

  Fly   353 SFVDNVNGTAIIDADLYKGGLFLGCTFGAVAMYIWGVGILAAGQSSTMTGTYAGQFSMEGFLNLQ 417
            ..:.|     ::.:.|.||           |..::.:.:|.:|||:.:..|.:||...|||||..
Yeast   348 FSIYN-----LLCSTLSKG-----------AGTVFVLALLFSGQSAGIVCTLSGQMVSEGFLNWT 396

  Fly   418 WPRWCRVLVTRCIAIIPTFCLAMFSKMEDLTSMNDILNAVMSLQLPFAAIPTIAFTSCAAIMGEF 482
            .....|...||.:||.|...|.:.:....|:...:....|:||.|||.:.|.:.|||...||...
Yeast   397 VSPALRRSATRAVAITPCLILVLVAGRSGLSGALNASQVVLSLLLPFVSAPLLYFTSSKKIMRVQ 461

  Fly   483 VN-----------------------------GLGNK-----------------------IVSILL 495
            :|                             |:|:.                       :::|::
Yeast   462 LNRTKELSRTTDKKPVADRTEDDETIELEEMGIGSSSQERSLVSPAPEYKDMSNGMIVTVLAIIV 526

  Fly   496 TIVVIGVNLYFVV 508
            .:::.|:|.|.::
Yeast   527 WLIISGLNFYMLL 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvl	NP_001262795.1	nramp	75..479	CDD:162246	134/436 (31%)
Mvl	NP_001262795.1	Nramp	97..486	CDD:279852	125/450 (28%)
SMF2	NP_011917.1	nramp	55..458	CDD:162246	134/436 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345361
Domainoid	1	1.000	165	1.000	Domainoid score	I821
eggNOG	1	0.900	-	-		E1_COG1914
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	194	1.000	Inparanoid score	I890
Isobase	1	0.950	-	0	Normalized mean entropy	S1387
OMA	1	1.010	-	-		QHG54724
OrthoFinder	1	1.000	-	-		FOG0000712
OrthoInspector	1	1.000	-	-		otm46851
orthoMCL	1	0.900	-	-		OOG6_100775
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2295
SonicParanoid	1	1.000	-	-		X461
TreeFam	1	0.960	-	-
	14	13.640