Protein Alignment Mvl and SMF2

DIOPT Version :10

• Sequence 1: NP_001262795.1
• Gene: Mvl / 42490
• FlyBaseID: FBgn0011672
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_011917.1
• Gene: SMF2 / 856447
• SGDID: S000001092
• Length: 549
• Species: Saccharomyces cerevisiae
• Alignment Length: 533
• Identity: 146/533 - (27%)
• Similarity: 244/533 - (45%)
• Gaps: 119/533 - (22%)

  Fly    61 LIPDDDSTNVGFSFRKLWAFTGPGFLMSIAYLDPGNIESDMQSGAAAKYKILWVLLWATVLGLLM 125
            |.|:..|.::..:.||...|.|||.::|::|:||||..:.:.:|:|.:||:|:.:|.:..:....
Yeast    41 LQPNSTSQSMIGTLRKYARFIGPGLMVSVSYMDPGNYSTAVAAGSAHRYKLLFSVLVSNFMAAFW 105

  Fly   126 QRLAARLGVVTGLHLAEMCYRQYKRLPRWI---LWIMIEIAIIGSDMQEVIGTAIAIYLLSNKVV 187
            |.|.||||.||||.||:.|   .|.||..:   |:|:.|:|||.:|:.||:||||::.:|.:  :
Yeast   106 QYLCARLGAVTGLDLAQNC---KKHLPFGLNITLYILAEMAIIATDLAEVVGTAISLNILFH--I 165

  Fly   188 PLWGGVLITIVDTFTFLFLDK-----YGLRKLEFLFGTLITIMAVSFGYE--YIVSAPNQGEVLE 245
            ||..||::|:||....|...|     .|:|..|.....|:.:..|.|..|  |....|.: |:..
Yeast   166 PLALGVILTVVDVLIVLLAYKPNGSMKGIRIFEAFVSLLVVLTVVCFTVELFYAKLGPAK-EIFS 229

  Fly   246 GMFVPWCSNCNSNVLLQAVGVVGAVIMPHNLYLHSALVKSR----------------DID----- 289
            | |:|..:....:.|..::.::||.:|||:|||.|.:|:.|                |:|
Yeast   230 G-FLPSKAVFEGDGLYLSLAILGATVMPHSLYLGSGVVQPRLREYDIKNGHYLPDANDMDNNHDN 293

  Fly   290 -RRQTKKVSEANFYFFIEASVALF-VSFIINLFVVAVFAHGMYGKTNNDVVEVCKDKSMYEDAKM 352
             |...:.:||...:...|..::|| |:..:|..::.|....:||.|.|           .|:|.:
Yeast   294 YRPSYEAISETLHFTITELLISLFTVALFVNCAILIVSGATLYGSTQN-----------AEEADL 347

  Fly   353 SFVDNVNGTAIIDADLYKGGLFLGCTFGAVAMYIWGVGILAAGQSSTMTGTYAGQFSMEGFLNLQ 417
            ..:.|     ::.:.|.||           |..::.:.:|.:|||:.:..|.:||...|||||..
Yeast   348 FSIYN-----LLCSTLSKG-----------AGTVFVLALLFSGQSAGIVCTLSGQMVSEGFLNWT 396

  Fly   418 WPRWCRVLVTRCIAIIPTFCLAMFSKMEDLTSMNDILNAVMSLQLPFAAIPTIAFTSCAAIMGEF 482
            .....|...||.:||.|...|.:.:....|:...:....|:||.|||.:.|.:.|||...||...
Yeast   397 VSPALRRSATRAVAITPCLILVLVAGRSGLSGALNASQVVLSLLLPFVSAPLLYFTSSKKIMRVQ 461

  Fly   483 VN-----------------------------GLGNK-----------------------IVSILL 495
            :|                             |:|:.                       :::|::
Yeast   462 LNRTKELSRTTDKKPVADRTEDDETIELEEMGIGSSSQERSLVSPAPEYKDMSNGMIVTVLAIIV 526

  Fly   496 TIVVIGVNLYFVV 508
            .:::.|:|.|.::
Yeast   527 WLIISGLNFYMLL 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mvl	NP_001262795.1	nramp	75..479	CDD:162246	134/436 (31%)
SMF2	NP_011917.1	nramp	55..458	CDD:162246	134/436 (31%)