DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mvl and NRAMP5

DIOPT Version :9

Sequence 1:	NP_001262795.1	Gene:	Mvl / 42490	FlyBaseID:	FBgn0011672	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_193614.1	Gene:	NRAMP5 / 827613	AraportID:	AT4G18790	Length:	530	Species:	Arabidopsis thaliana

Alignment Length:	533	Identity:	231/533 - (43%)
Similarity:	320/533 - (60%)	Gaps:	61/533 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 NQLHHQQILNETTYLKPAAKQAYFSDEKVLIPDDDSTNVGFSFRKLWAFTGPGFLMSIAYLDPGN 96
            ::||.....|:...::....:.|.|     :|.       ||:.|||.|||||||||||:|||||
plant    37 DELHESPPENQILNVEEDRDKTYDS-----VPP-------FSWAKLWKFTGPGFLMSIAFLDPGN 89

  Fly    97 IESDMQSGAAAKYKILWVLLWATVLGLLMQRLAARLGVVTGLHLAEMCYRQYKRLPRWILWIMIE 161
            ||.|:|:||.|.|.:||:|||||::|||||.|:||:||.||.||||:|..:|....|.:||.|.|
plant    90 IEGDLQAGAVAGYSLLWLLLWATLMGLLMQLLSARIGVATGRHLAEICRSEYPSWARILLWFMAE 154

  Fly   162 IAIIGSDMQEVIGTAIAIYLLSNKVVPLWGGVLITIVDTFTFLFLDKYGLRKLEFLFGTLITIMA 226
            :|:||:|:|||||:|||:.:|:...:|:|.||:||..|.|...:|:|.|:||||.||..||..||
plant   155 VALIGADIQEVIGSAIALQILTRGFLPIWVGVIITSFDCFLISYLEKCGMRKLEGLFAVLIATMA 219

  Fly   227 VSFGYEYIVSAPNQGEVLEGMFVPWCSNCNSNVLLQAVGVVGAVIMPHNLYLHSALVKSRDIDRR 291
            :||.:.:..:.|:..|:..|:.:|   ...|..:.:||||||.||.|||::||||||:||..|.:
plant   220 LSFAWMFNETKPSVEELFIGIIIP---KLGSKTIREAVGVVGCVITPHNVFLHSALVQSRKTDPK 281

  Fly   292 QTKKVSEANFYFFIEASVALFVSFIINLFVVAVFAHGMYGKTNNDVVEVCKDKSMYEDAKMSFVD 356
            :..:|.||..|:.||:|.||||||:|||||.||||.|.||....|.:.:
plant   282 EINRVQEALNYYTIESSAALFVSFMINLFVTAVFAKGFYGTKQADSIGL---------------- 330

  Fly   357 NVNGTAIIDADLYKGGLFLGCTFGAVAMYIWGVGILAAGQSSTMTGTYAGQFSMEGFLNLQWPRW 421
             ||....:. :.|.||:|       ..:||||:|:||||||||:||||||||.|||||:||..:|
plant   331 -VNAGYYLQ-EKYGGGVF-------PILYIWGIGLLAAGQSSTITGTYAGQFIMEGFLDLQMEQW 386

  Fly   422 CRVLVTRCIAIIPT-FCLAMFSKME-DLTSMNDILNAVMSLQLPFAAIPTIAFTSCAAIMGEFVN 484
            ....:||..||:|| |...||:..| .|..:|:.||.:.|:|:|||.||.:...|...|||.|..
plant   387 LSAFITRSFAIVPTMFVAIMFNTSEGSLDVLNEWLNILQSMQIPFAVIPLLTMVSNEHIMGVFKI 451

  Fly   485 GLGNKIVSILLTIVVIGVNLY----FVVVQVENMEIKGGLLALVCIF--AILYILFNLYLVIHMA 543
            |...:.::..:.:.|:.:|.|    |.:.:||      |.|....:|  .:.||.|.:|||.:.:
plant   452 GPSLEKLAWTVAVFVMMINGYLLLDFFMAEVE------GFLVGFLVFGGVVGYISFIIYLVSYRS 510

  Fly   544 ACMGNQRLMNSRW 556
            :       .:|.|
plant   511 S-------QSSSW 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvl	NP_001262795.1	nramp	75..479	CDD:162246	201/405 (50%)
Mvl	NP_001262795.1	Nramp	97..486	CDD:279852	186/390 (48%)
NRAMP5	NP_193614.1	SLC5-6-like_sbd	68..446	CDD:294310	201/405 (50%)
NRAMP5	NP_193614.1	Nramp	90..453	CDD:279852	186/390 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	360	1.000	Domainoid score	I196
eggNOG	1	0.900	-	-		E1_COG1914
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55471
Inparanoid	1	1.050	429	1.000	Inparanoid score	I420
OMA	1	1.010	-	-		QHG54724
OrthoDB	1	1.010	-	-		D666470at2759
OrthoFinder	1	1.000	-	-		FOG0000712
OrthoInspector	1	1.000	-	-		otm2579
orthoMCL	1	0.900	-	-		OOG6_100775
Panther	1	1.100	-	-	O	PTHR11706
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X461
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840