DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mvl and NRAMP3

DIOPT Version :9

Sequence 1:	NP_001262795.1	Gene:	Mvl / 42490	FlyBaseID:	FBgn0011672	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_179896.1	Gene:	NRAMP3 / 816847	AraportID:	AT2G23150	Length:	509	Species:	Arabidopsis thaliana

Alignment Length:	528	Identity:	243/528 - (46%)
Similarity:	332/528 - (62%)	Gaps:	59/528 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QLHHQQ--ILNETTYLKPAAKQAYFSDEKVLI-----PDDDSTNVG------FSFRKLWAFTGPG 84
            ||.:.:  ::||    :...:.||...|||.|     .||....||      ||::|||.|||||
plant     3 QLENNEPLLINE----EEEEETAYDETEKVHIVRNEEEDDLEHGVGCGGAPPFSWKKLWLFTGPG 63

  Fly    85 FLMSIAYLDPGNIESDMQSGAAAKYKILWVLLWATVLGLLMQRLAARLGVVTGLHLAEMCYRQYK 149
            ||||||:|||||:|.|:|:||.|.|.:||:|:|||.:|||:|.|:|||||.||.||||:|..:|.
plant    64 FLMSIAFLDPGNLEGDLQAGAVAGYSLLWLLMWATAMGLLVQLLSARLGVATGRHLAELCRDEYP 128

  Fly   150 RLPRWILWIMIEIAIIGSDMQEVIGTAIAIYLLSNKVVPLWGGVLITIVDTFTFLFLDKYGLRKL 214
            ...|.:||:|.|:|:||||:|||||:||||.:|||.::|||.||:||.:|.|.||||:.||:|||
plant   129 TWARMVLWVMAELALIGSDIQEVIGSAIAIKILSNGILPLWAGVVITALDCFVFLFLENYGIRKL 193

  Fly   215 EFLFGTLITIMAVSFGYEYIVSAPNQGEVLEGMFVPWCSNCNSNVLLQAVGVVGAVIMPHNLYLH 279
            |.:|..||..|.|||.:.:..:.|:..|:|.|:.||   ..:|..:.:||||||.:|||||::||
plant   194 EAVFAVLIATMGVSFAWMFGQAKPSGSELLIGILVP---KLSSRTIQKAVGVVGCIIMPHNVFLH 255

  Fly   280 SALVKSRDIDRRQTKKVSEANFYFFIEASVALFVSFIINLFVVAVFAHGMYGKTNNDVVEVCKDK 344
            ||||:||::|:||..:|.||..|:.||:::|||:||:|||||..|||.|.|   |.|:
plant   256 SALVQSREVDKRQKYRVQEALNYYTIESTIALFISFLINLFVTTVFAKGFY---NTDL------- 310

  Fly   345 SMYEDAKMSFVDNVNGTAIIDA-----DLYKGGLFLGCTFGAVAMYIWGVGILAAGQSSTMTGTY 404
                         .|...:::|     :.|.||:|       ..:|||.:|:||||||||:||||
plant   311 -------------ANSIGLVNAGQYLQEKYGGGVF-------PILYIWAIGLLAAGQSSTITGTY 355

  Fly   405 AGQFSMEGFLNLQWPRWCRVLVTRCIAIIPTFCLAM-FSKME-DLTSMNDILNAVMSLQLPFAAI 467
            ||||.|.||||.:..:|.|.|:||..|||||..:|: |...| .|..:|:.||.:.|:|:|||.|
plant   356 AGQFIMGGFLNFKMKKWLRALITRSCAIIPTIIVALVFDSSEATLDVLNEWLNVLQSIQIPFALI 420

  Fly   468 PTIAFTSCAAIMGEFVNGLGNKIVSILLTIVVIGVNLYFVVVQVENMEIKGGL-LALVCIFAILY 531
            |.:...|...|||.|..|...|.::.|:..:||.:|.|.::....| |:.|.: ...|.:|...|
plant   421 PLLCLVSKEQIMGSFKIGPLYKTIAWLVAALVIMINGYLLLEFFSN-EVSGIVYTGFVTLFTASY 484

  Fly   532 ILFNLYLV 539
            ..|.|||:
plant   485 GAFILYLI 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvl	NP_001262795.1	nramp	75..479	CDD:162246	206/410 (50%)
Mvl	NP_001262795.1	Nramp	97..486	CDD:279852	191/395 (48%)
NRAMP3	NP_179896.1	SLC5-6-like_sbd	54..432	CDD:382020	206/410 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	360	1.000	Domainoid score	I196
eggNOG	1	0.900	-	-		E1_COG1914
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	429	1.000	Inparanoid score	I420
OMA	1	1.010	-	-		QHG54724
OrthoDB	1	1.010	-	-		D666470at2759
OrthoFinder	1	1.000	-	-		FOG0000712
OrthoInspector	1	1.000	-	-		otm2579
orthoMCL	1	0.900	-	-		OOG6_100775
Panther	1	1.100	-	-	O	PTHR11706
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X461
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840