DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mvl and SLC11A1

DIOPT Version :9

Sequence 1:	NP_001262795.1	Gene:	Mvl / 42490	FlyBaseID:	FBgn0011672	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_000569.3	Gene:	SLC11A1 / 6556	HGNCID:	10907	Length:	550	Species:	Homo sapiens

Alignment Length:	544	Identity:	306/544 - (56%)
Similarity:	384/544 - (70%)	Gaps:	32/544 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GGDGPGGSSGASGGGSQRSNQLHHQQILNETTYLKPAAKQA-----YFSDEKVLIPDDDSTNVG- 71
            |..||...||:|.|           .|.:.|:...|..:||     |.| ||:.|||   |..|
Human     3 GDKGPQRLSGSSYG-----------SISSPTSPTSPGPQQAPPRETYLS-EKIPIPD---TKPGT 52

  Fly    72 FSFRKLWAFTGPGFLMSIAYLDPGNIESDMQSGAAAKYKILWVLLWATVLGLLMQRLAARLGVVT 136
            ||.||||||||||||||||:|||||||||:|:||.|.:|:|||||||||||||.|||||||||||
Human    53 FSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVT 117

  Fly   137 GLHLAEMCYRQYKRLPRWILWIMIEIAIIGSDMQEVIGTAIAIYLLSNKVVPLWGGVLITIVDTF 201
            |..|.|:|:..|.::||.:||:.||:||:|||||||||||||..|||...:||||||||||||||
Human   118 GKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVDTF 182

  Fly   202 TFLFLDKYGLRKLEFLFGTLITIMAVSFGYEYIVSAPNQGEVLEGMFVPWCSNCNSNVLLQAVGV 266
            .|||||.|||||||..||.||||||::|||||:|:.|.||.:|.|:|:|.|..|....||||||:
Human   183 FFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPELLQAVGI 247

  Fly   267 VGAVIMPHNLYLHSALVKSRDIDRRQTKKVSEANFYFFIEASVALFVSFIINLFVVAVFAHGMYG 331
            |||:|||||:||||||||||:|||.:...:.|||.||.|||::||.|||||||||:|||....|.
Human   248 VGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQ 312

  Fly   332 KTNNDVVEVCKDKSMYEDAKMSFVDNVNGTAIIDADLYKGGLFLGCTFGAVAMYIWGVGILAAGQ 396
            |||.....:|.:.|:::.||:..::|    |.:..|:|:||:.|||.||..|:|||.:|:|||||
Human   313 KTNQAAFNICANSSLHDYAKIFPMNN----ATVAVDIYQGGVILGCLFGPAALYIWAIGLLAAGQ 373

  Fly   397 SSTMTGTYAGQFSMEGFLNLQWPRWCRVLVTRCIAIIPTFCLAMFSKMEDLTSMNDILNAVMSLQ 461
            ||||||||||||.|||||.|:|.|:.|||:||..||:||..:|:|..:.||:.:||:||.:.||.
Human   374 SSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLL 438

  Fly   462 LPFAAIPTIAFTSCAAIMGEFVNGLGNKIVSILLTIVVIGVNLYFVVVQVENMEIKG--GLLALV 524
            ||||.:|.:.|||...:|.||.|||.||:|:..:.::|..:||||||..:.::....  ||.||:
Human   439 LPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALL 503

  Fly   525 CIFAILYILFNLYLVIHMAACMGN 548
               |..|:..:.|||  ...|:.:
Human   504 ---AAAYLGLSTYLV--WTCCLAH 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvl	NP_001262795.1	nramp	75..479	CDD:162246	257/403 (64%)
Mvl	NP_001262795.1	Nramp	97..486	CDD:279852	240/388 (62%)
SLC11A1	NP_000569.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		16/53 (30%)
		nramp	56..456	CDD:162246	257/403 (64%)
		Nramp	78..463	CDD:279852	240/388 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155484
Domainoid	1	1.000	510	1.000	Domainoid score	I320
eggNOG	1	0.900	-	-		E1_COG1914
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	599	1.000	Inparanoid score	I960
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54724
OrthoDB	1	1.010	-	-		D252569at33208
OrthoFinder	1	1.000	-	-		FOG0000712
OrthoInspector	1	1.000	-	-		otm41634
orthoMCL	1	0.900	-	-		OOG6_100775
Panther	1	1.100	-	-	O	PTHR11706
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2295
SonicParanoid	1	1.000	-	-		X461
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800