DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mvl and SLC11A2

DIOPT Version :9

Sequence 1:	NP_001262795.1	Gene:	Mvl / 42490	FlyBaseID:	FBgn0011672	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001366375.1	Gene:	SLC11A2 / 4891	HGNCID:	10908	Length:	597	Species:	Homo sapiens

Alignment Length:	529	Identity:	313/529 - (59%)
Similarity:	394/529 - (74%)	Gaps:	25/529 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GPGGSSGASGGGSQRSNQLHHQQILNETTYLKPAAKQAYFS---DEKVLIPDDDSTNVGFSFRKL 77
            |..|.|.:.|    ..|..:....|:::    |...:.||:   :||:.||:::.:  .||||||
Human    45 GDHGESASLG----NINPAYSNPSLSQS----PGDSEEYFATYFNEKISIPEEEYS--CFSFRKL 99

  Fly    78 WAFTGPGFLMSIAYLDPGNIESDMQSGAAAKYKILWVLLWATVLGLLMQRLAARLGVVTGLHLAE 142
            |||||||||||||||||||||||:||||.|.:|:||:||.||::|||:|||||||||||||||||
Human   100 WAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAE 164

  Fly   143 MCYRQYKRLPRWILWIMIEIAIIGSDMQEVIGTAIAIYLLSNKVVPLWGGVLITIVDTFTFLFLD 207
            :|:|||.::||.|||:|:|:||||||||||||:||||.|||...:||||||||||.|||.|||||
Human   165 VCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLD 229

  Fly   208 KYGLRKLEFLFGTLITIMAVSFGYEYIVSAPNQGEVLEGMFVPWCSNCNSNVLLQAVGVVGAVIM 272
            ||||||||..||.||||||::|||||:...|:|.:||:|||||.||.|.:..:.||||:||||||
Human   230 KYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIM 294

  Fly   273 PHNLYLHSALVKSRDIDRRQTKKVSEANFYFFIEASVALFVSFIINLFVVAVFAHGMYGKTNNDV 337
            |||:||||||||||.::|...::|.|||.|||||:.:|||||||||:|||:|||...:||||..|
Human   295 PHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQV 359

  Fly   338 VEVCKDKSMYEDAKMSFVDNVNGTAIIDADLYKGGLFLGCTFGAVAMYIWGVGILAAGQSSTMTG 402
            ||||.:.|. ..|.:...||    :.:..|:||||:.|||.||..|:|||.||||||||||||||
Human   360 VEVCTNTSS-PHAGLFPKDN----STLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTG 419

  Fly   403 TYAGQFSMEGFLNLQWPRWCRVLVTRCIAIIPTFCLAMFSKMEDLTSMNDILNAVMSLQLPFAAI 467
            ||:|||.|||||||:|.|:.||::||.||||||..:|:|..:|.||.|||.||.:.|||||||.|
Human   420 TYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALI 484

  Fly   468 PTIAFTSCAAIMGEFVNGLGNKIVSILLTIVVIGVNLYFVVVQVENMEIKGGLLALVCIFAIL-- 530
            |.:.|||...:|.:|.||||.:|...:|.:::..:|:|||||.|.::    |.:||..:.|::
Human   485 PILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDL----GHVALYVVAAVVSV 545

  Fly   531 -YILFNLYL 538
             |:.|..||
Human   546 AYLGFVFYL 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvl	NP_001262795.1	nramp	75..479	CDD:162246	274/403 (68%)
Mvl	NP_001262795.1	Nramp	97..486	CDD:279852	255/388 (66%)
SLC11A2	NP_001366375.1	nramp	97..496	CDD:162246	274/403 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	510	1.000	Domainoid score	I320
eggNOG	1	0.900	-	-		E1_COG1914
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55471
Inparanoid	1	1.050	599	1.000	Inparanoid score	I960
Isobase	1	0.950	-	0	Normalized mean entropy	S1387
OMA	1	1.010	-	-		QHG54724
OrthoDB	1	1.010	-	-		D252569at33208
OrthoFinder	1	1.000	-	-		FOG0000712
OrthoInspector	1	1.000	-	-		otm41634
orthoMCL	1	0.900	-	-		OOG6_100775
Panther	1	1.100	-	-	LDO	PTHR11706
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2295
SonicParanoid	1	1.000	-	-		X461
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.820