DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mvl and Slc11a1

DIOPT Version :9

Sequence 1:	NP_001262795.1	Gene:	Mvl / 42490	FlyBaseID:	FBgn0011672	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_006245281.1	Gene:	Slc11a1 / 316519	RGDID:	1601463	Length:	549	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	301/543 - (55%)
Similarity:	385/543 - (70%)	Gaps:	21/543 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QRSNQLHHQQILNETTYLKPA-----AKQAYFSDEKVLIPDDDSTNVG-FSFRKLWAFTGPGFLM 87
            ||.|:..:..|   ::...||     ::..|.| ||:.||   ||..| ||.|||||||||||||
  Rat     9 QRVNRPSYGSI---SSLPSPAPQPEPSRNTYLS-EKIPIP---STEQGTFSLRKLWAFTGPGFLM 66

  Fly    88 SIAYLDPGNIESDMQSGAAAKYKILWVLLWATVLGLLMQRLAARLGVVTGLHLAEMCYRQYKRLP 152
            |||:|||||||||:|:||.|::|:|||||||||||||.||||||||||||..|.|:|:..|.::|
  Rat    67 SIAFLDPGNIESDLQAGAVAEFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEICHLYYPKVP 131

  Fly   153 RWILWIMIEIAIIGSDMQEVIGTAIAIYLLSNKVVPLWGGVLITIVDTFTFLFLDKYGLRKLEFL 217
            |.:||:.||:||:||||||||||||:..|||...:||||||||||||||.|||||.|||||||..
  Rat   132 RILLWLTIELAIVGSDMQEVIGTAISFNLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAF 196

  Fly   218 FGTLITIMAVSFGYEYIVSAPNQGEVLEGMFVPWCSNCNSNVLLQAVGVVGAVIMPHNLYLHSAL 282
            ||.||||||::|||||:|:.|:||.:|:|:|:|.|..|....||||||:|||:|||||:||||||
  Rat   197 FGFLITIMALTFGYEYVVARPSQGALLKGLFLPSCPGCGQPELLQAVGIVGAIIMPHNIYLHSAL 261

  Fly   283 VKSRDIDRRQTKKVSEANFYFFIEASVALFVSFIINLFVVAVFAHGMYGKTNNDVVEVCKDKSMY 347
            ||||::||.:...|.|||.||..||::||||||||||||:|||....|.:||.:...:|.:.|::
  Rat   262 VKSREVDRTRRGDVREANMYFLTEATIALFVSFIINLFVMAVFGQAFYQQTNEEAFNICANSSLH 326

  Fly   348 EDAKMSFVDNVNGTAIIDADLYKGGLFLGCTFGAVAMYIWGVGILAAGQSSTMTGTYAGQFSMEG 412
            ..||:...||    ..:..|:|:||:.|||.||..|:|||.||:|||||||||||||||||.|||
  Rat   327 NYAKIFPRDN----NTVSVDIYQGGVILGCLFGPAALYIWAVGLLAAGQSSTMTGTYAGQFVMEG 387

  Fly   413 FLNLQWPRWCRVLVTRCIAIIPTFCLAMFSKMEDLTSMNDILNAVMSLQLPFAAIPTIAFTSCAA 477
            ||.|:|.|:.|||:||..||:||..:|:|..:.||:.:||:||.:.||.||||.:|.:.|||..|
  Rat   388 FLKLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPA 452

  Fly   478 IMGEFVNGLGNKIVSILLTIVVIGVNLYFVVVQVENMEIKGGLLALVCIFAILYILFNLYLVIHM 542
            :|.||.||..:|:::..:..:|..:|||||:..:.::. ......||.:.||.|:....||....
  Rat   453 VMQEFANGWLSKVITSCIMALVCAINLYFVISYLPSLP-HPAYFGLVALLAIGYLGLTAYLAWTC 516

  Fly   543 AACMGNQRLMNSRWVQRFV--LP 563
            ....|.:.|.:|.. |||:  ||
  Rat   517 CIAHGAKFLTHSSH-QRFLYGLP 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvl	NP_001262795.1	nramp	75..479	CDD:162246	257/403 (64%)
Mvl	NP_001262795.1	Nramp	97..486	CDD:279852	240/388 (62%)
Slc11a1	XP_006245281.1	nramp	54..454	CDD:162246	257/403 (64%)
Slc11a1	XP_006245281.1	Nramp	76..461	CDD:279852	240/388 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349368
Domainoid	1	1.000	508	1.000	Domainoid score	I312
eggNOG	1	0.900	-	-		E1_COG1914
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54724
OrthoDB	1	1.010	-	-		D252569at33208
OrthoFinder	1	1.000	-	-		FOG0000712
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100775
Panther	1	1.100	-	-	O	PTHR11706
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X461
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.760