DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mvl and pdt1

DIOPT Version :9

Sequence 1:	NP_001262795.1	Gene:	Mvl / 42490	FlyBaseID:	FBgn0011672	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_594537.1	Gene:	pdt1 / 2542283	PomBaseID:	SPAC27F1.08	Length:	521	Species:	Schizosaccharomyces pombe

Alignment Length:	531	Identity:	158/531 - (29%)
Similarity:	252/531 - (47%)	Gaps:	101/531 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 NQLHHQQILNETTYLKPAAKQAYFSDEKVLIPDDDSTNVGFSFRKLW-----------AFTGPGF 85
            |:|:.:|  |:|.           ....:|:.|......|||  |.|           .|.||||
pombe    30 NELNPEQ--NDTR-----------RSTDLLLEDKYGIQTGFS--KYWKKCTYGIREYCKFIGPGF 79

  Fly    86 LMSIAYLDPGNIESDMQSGAAAKYKILWVLLWATVLGLLMQRLAARLGVVTGLHLAEMCYRQYKR 150
            |:::||:||||..:|:.:|:..:||:|:::..:.:..:.:|.|..|||.|||:.||..|...|.|
pombe    80 LIAVAYIDPGNYSTDLDAGSRFQYKLLFIVFLSNLFAVYLQSLCIRLGSVTGMDLARNCREHYNR 144

  Fly   151 LPRWILWIMIEIAIIGSDMQEVIGTAIAIYLLSNKVVPLWGGVLITIVDTFTFLFL-----DKYG 210
            ...|..:::.|||||.:|:.||||||:|:.:|.:  :||..||:|||:|....|..     ....
pombe   145 YICWSFYVLAEIAIIATDIAEVIGTAVALKILMH--IPLVAGVVITILDVLLVLIAWRPEGSMLS 207

  Fly   211 LRKLEFLFGTLITIMAVSF----GYEYIVSAPNQGEVLEGMFVPWCSNCNSNVLLQAVGVVGAVI 271
            :|..|.....|:.::|:||    |..:|..|   |.|.:| |:|..:..:...|..::|::||.:
pombe   208 VRIFETAVALLVLVVAISFAVVLGRVHIGGA---GTVFKG-FLPSSTVFSREGLYSSIGILGATV 268

  Fly   272 MPHNLYLHSALVKSR----DIDRRQTKKVSEANFY----FFIEASVAL-FVSFIINLFVVAVFAH 327
            |||:|:|.|.||::|    |:.|.....|.:.:.|    ..|:.|:.. .|...::||..|:|
pombe   269 MPHSLFLGSGLVQTRLRDLDVRRGNYTPVGDCSDYRPTHETIKHSLTYSIVEVALSLFTFALF-- 331

  Fly   328 GMYGKTNNDVVEVCKDKSMYEDAKMSFVDNVNGTAIIDA----DLYKGGLFLGCTFGAVAMYIWG 388
                 ||:.::.|         |...|. |.:|....|.    ||.|..:.:.|.      .::.
pombe   332 -----TNSSILIV---------AGAVFY-NTSGADTSDLFSIYDLLKEYVSISCG------RLFA 375

  Fly   389 VGILAAGQSSTMTGTYAGQFSMEGFLNLQWPRWCRVLVTRCIAIIPTFCLAMFSKMEDLTSMNDI 453
            |.:|.:|.|:....|.|||...||::|.....|.|.::||.|||||  ||.: |.....:.:|.:
pombe   376 VALLFSGMSAGYVCTIAGQIVSEGYINWNLRPWLRRVITRAIAIIP--CLVV-SAAVGQSGLNQV 437

  Fly   454 LNA---VMSLQLPFAAIPTIAFTSCAAIM-----------GEFVN-------GLGNKIVSILLTI 497
            |||   .:|:.|||...|.:.||....:|           |:.:.       |....||:..:.:
pombe   438 LNASQVCLSILLPFLTFPLVMFTCSRKVMRVVSDSTNEETGQLIRETHDYSLGWTMTIVTWAIWL 502

  Fly   498 VVIGVNLYFVV 508
            .:..:||..:|
pombe   503 FLTALNLLLIV 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvl	NP_001262795.1	nramp	75..479	CDD:162246	140/439 (32%)
Mvl	NP_001262795.1	Nramp	97..486	CDD:279852	128/431 (30%)
pdt1	NP_594537.1	nramp	69..466	CDD:162246	138/428 (32%)
pdt1	NP_594537.1	Nramp	93..466	CDD:279852	126/404 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	159	1.000	Domainoid score	I1005
eggNOG	1	0.900	-	-		E1_COG1914
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	190	1.000	Inparanoid score	I1060
OMA	1	1.010	-	-		QHG54724
OrthoFinder	1	1.000	-	-		FOG0000712
OrthoInspector	1	1.000	-	-		oto101541
orthoMCL	1	0.900	-	-		OOG6_100775
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2295
SonicParanoid	1	1.000	-	-		X461
TreeFam	1	0.960	-	-
	12	11.760