Protein Alignment Mvl and Slc11a2

DIOPT Version :10

• Sequence 1: NP_001262795.1
• Gene: Mvl / 42490
• FlyBaseID: FBgn0011672
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: XP_011243789.1
• Gene: Slc11a2 / 18174
• MGIID: 1345279
• Length: 598
• Species: Mus musculus
• Alignment Length: 544
• Identity: 323/544 - (59%)
• Similarity: 394/544 - (72%)
• Gaps: 27/544 - (4%)

  Fly     1 MSSNEAYHEPGAGGD-GPGGSSGASGGGSQRSNQLHHQQILNE--TTYLKPAAKQAYFSDEKVLI 62
            :...|...:.||.|| |...|.||.......|:..|......|  |||.          |||:.|
Mouse    33 LDPKEKMPDDGASGDHGDSASLGAINPAYSNSSLPHSTGDSEEPFTTYF----------DEKIPI 87

  Fly    63 PDDDSTNVGFSFRKLWAFTGPGFLMSIAYLDPGNIESDMQSGAAAKYKILWVLLWATVLGLLMQR 127
            |:::.:  .|||||||||||||||||||||||||||||:||||.|.:|:|||||.||::|||:||
Mouse    88 PEEEYS--CFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWVLLLATIVGLLLQR 150

  Fly   128 LAARLGVVTGLHLAEMCYRQYKRLPRWILWIMIEIAIIGSDMQEVIGTAIAIYLLSNKVVPLWGG 192
            |||||||||||||||:|:|||.::||.|||:|:|:||||||||||||:||||.|||...||||||
Mouse   151 LAARLGVVTGLHLAEVCHRQYPKVPRIILWLMVELAIIGSDMQEVIGSAIAINLLSAGRVPLWGG 215

  Fly   193 VLITIVDTFTFLFLDKYGLRKLEFLFGTLITIMAVSFGYEYIVSAPNQGEVLEGMFVPWCSNCNS 257
            |||||.|||.|||||||||||||..||.||||||::||||||...|:|.:||.|||||.|..|.:
Mouse   216 VLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYITVKPSQSQVLRGMFVPSCPGCRT 280

  Fly   258 NVLLQAVGVVGAVIMPHNLYLHSALVKSRDIDRRQTKKVSEANFYFFIEASVALFVSFIINLFVV 322
            ..:.||||:|||||||||:||||||||||.::|...::|.|||.|||||:.:|||||||||:|||
Mouse   281 PQVEQAVGIVGAVIMPHNMYLHSALVKSRQVNRANKQEVREANKYFFIESCIALFVSFIINVFVV 345

  Fly   323 AVFAHGMYGKTNNDVVEVCKDKSMYEDAKMSFVDNVNGTAIIDADLYKGGLFLGCTFGAVAMYIW 387
            :|||...:.|||..||||||:.|. ..|.:...||    :.:..|:||||:.|||.||..|:|||
Mouse   346 SVFAEAFFEKTNKQVVEVCKNNSS-PHADLFPSDN----STLAVDIYKGGVVLGCYFGPAALYIW 405

  Fly   388 GVGILAAGQSSTMTGTYAGQFSMEGFLNLQWPRWCRVLVTRCIAIIPTFCLAMFSKMEDLTSMND 452
            .||||||||||||||||:|||.|||||||:|.|:.||::||.||||||..:|:|..:|.||.|||
Mouse   406 AVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVILTRSIAIIPTLLVAVFQDVEHLTGMND 470

  Fly   453 ILNAVMSLQLPFAAIPTIAFTSCAAIMGEFVNGLGNKIVSILLTIVVIGVNLYFVVVQVENMEIK 517
            .||.:.|||||||.||.:.|||...:|.||.||:|.:|...:|.::|..:|:|||||.|:.:
Mouse   471 FLNVLQSLQLPFALIPILTFTSLRPVMSEFSNGIGWRIAGGILVLIVCSINMYFVVVYVQEL--- 532

  Fly   518 GGLLALVCIFAIL---YILFNLYL 538
             |.:||..:.|::   |:.|..||
Mouse   533 -GHVALYVVAAVVSVAYLTFVFYL 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mvl	NP_001262795.1	nramp	75..479	CDD:162246	276/403 (68%)
Slc11a2	XP_011243789.1	nramp	98..497	CDD:162246	276/403 (68%)