DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mvl and smf-1

DIOPT Version :9

Sequence 1:	NP_001262795.1	Gene:	Mvl / 42490	FlyBaseID:	FBgn0011672	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001024792.2	Gene:	smf-1 / 180939	WormBaseID:	WBGene00004876	Length:	562	Species:	Caenorhabditis elegans

Alignment Length:	493	Identity:	284/493 - (57%)
Similarity:	370/493 - (75%)	Gaps:	8/493 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 SDEKVLIPDDDSTNVGFSFRKLWAFTGPGFLMSIAYLDPGNIESDMQSGAAAKYKILWVLLWATV 120
            |.|:|.||.|| ....|||:|||||||||||||||||||||||||:||||.|.||:|||||.|.:
Worm    36 SQERVDIPVDD-VEKAFSFKKLWAFTGPGFLMSIAYLDPGNIESDLQSGAQAAYKLLWVLLSAHI 99

  Fly   121 LGLLMQRLAARLGVVTGLHLAEMCYRQYKRLPRWILWIMIEIAIIGSDMQEVIGTAIAIYLLSNK 185
            :|:|:||::||||||:|.|:||:.|:.|.||||.|||:||||||:.|||||||||||||:|||..
Worm   100 IGMLLQRMSARLGVVSGKHMAEVAYQFYPRLPRIILWLMIEIAIVCSDMQEVIGTAIAIFLLSKG 164

  Fly   186 VVPLWGGVLITIVDTFTFLFLDKYGLRKLEFLFGTLITIMAVSFGYEYIVSAPNQGEVLEGMFVP 250
            .|||:.||.|||:||||||.:|:||:||||.:||.||..|.||||||::|..|..|||:.||.||
Worm   165 FVPLYVGVFITILDTFTFLLIDRYGIRKLELIFGFLILTMTVSFGYEFVVVKPPIGEVISGMVVP 229

  Fly   251 WCSNCNSNVLLQAVGVVGAVIMPHNLYLHSALVKSRDIDRRQTKKVSEANFYFFIEASVALFVSF 315
            ||:.|.....:||:.|||||||||||||||||||||.:||:..::|:|||.||.:|:::|||:||
Worm   230 WCAGCGKGEFMQAISVVGAVIMPHNLYLHSALVKSRRVDRKDRRRVAEANKYFTLESAIALFLSF 294

  Fly   316 IINLFVVAVFAHGMYGKTNNDVVEVCKDKSMYEDAKMSFVDNVNGTAIIDADLYKGGLFLGCTFG 380
            .||||||||||||:|.|||.||.|:|..:....||.:.    .|.|..::.|:||||::|||.||
Worm   295 FINLFVVAVFAHGLYQKTNADVREMCIARHDIPDADIF----PNNTEPVEVDIYKGGIYLGCQFG 355

  Fly   381 AVAMYIWGVGILAAGQSSTMTGTYAGQFSMEGFLNLQWPRWCRVLVTRCIAIIPTFCLAMFSK-M 444
            |:||:|||:||.||||||||||||.|||.||||:.::||:|.|||:||.|||.||..|..:|: :
Worm   356 AIAMFIWGIGIFAAGQSSTMTGTYTGQFVMEGFVKIEWPKWKRVLITRAIAITPTLVLTFYSQGV 420

  Fly   445 EDLTSMNDILNAVMSLQLPFAAIPTIAFTSCAAIMGEFVNGLGNKIVSILLTIVVIGVNLYFVVV 509
            ::||.|||.||.|..:|||||.||.|.|||...||.:|.:....:|.:::.:.:::.:|:||:..
Worm   421 QNLTGMNDFLNCVQMIQLPFALIPIITFTSSRKIMHDFRSSKVFQIFALITSALILSINVYFISD 485

  Fly   510 QV-ENMEIKGGLLALVCIFAILYILFNLYLVIH-MAAC 545
            .| ..:..:..::.::......|:||.|||.:: :.:|
Worm   486 YVFSRLGSEWYIIMVLAPITFAYVLFVLYLALYCLVSC 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvl	NP_001262795.1	nramp	75..479	CDD:162246	259/404 (64%)
Mvl	NP_001262795.1	Nramp	97..486	CDD:279852	241/389 (62%)
smf-1	NP_001024792.2	nramp	54..455	CDD:162246	259/404 (64%)
smf-1	NP_001024792.2	Nramp	76..462	CDD:279852	241/389 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158881
Domainoid	1	1.000	492	1.000	Domainoid score	I182
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55471
Inparanoid	1	1.050	569	1.000	Inparanoid score	I579
Isobase	1	0.950	-	0	Normalized mean entropy	S1387
OMA	1	1.010	-	-		QHG54724
OrthoDB	1	1.010	-	-		D252569at33208
OrthoFinder	1	1.000	-	-		FOG0000712
OrthoInspector	1	1.000	-	-		otm14190
orthoMCL	1	0.900	-	-		OOG6_100775
Panther	1	1.100	-	-	LDO	PTHR11706
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2295
SonicParanoid	1	1.000	-	-		X461
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890