DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mvl and slc11a2

DIOPT Version :9

Sequence 1:	NP_001262795.1	Gene:	Mvl / 42490	FlyBaseID:	FBgn0011672	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_012811868.1	Gene:	slc11a2 / 100144712	XenbaseID:	XB-GENE-487563	Length:	560	Species:	Xenopus tropicalis

Alignment Length:	526	Identity:	316/526 - (60%)
Similarity:	397/526 - (75%)	Gaps:	23/526 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SNQLHHQQILNETTYLKPAAK----QAYFSDEKVLIPDDDSTNVGFSFRKLWAFTGPGFLMSIAY 91
            |.:...:|.|::|: .:||.:    ..|| |||:.||:|: |:..||||||||||||||||||||
Frog    14 SGETLSKQNLSDTS-PEPAVEVEPFATYF-DEKIPIPEDE-THSWFSFRKLWAFTGPGFLMSIAY 75

  Fly    92 LDPGNIESDMQSGAAAKYKILWVLLWATVLGLLMQRLAARLGVVTGLHLAEMCYRQYKRLPRWIL 156
            |||||||||:|||:.|.:|:|||||.||::|||:|||||||||||||||||:|.|||.::||.||
Frog    76 LDPGNIESDLQSGSVAGFKLLWVLLAATIIGLLLQRLAARLGVVTGLHLAEVCNRQYPKVPRIIL 140

  Fly   157 WIMIEIAIIGSDMQEVIGTAIAIYLLSNKVVPLWGGVLITIVDTFTFLFLDKYGLRKLEFLFGTL 221
            |:|:|:||||||||||||:|||:.|||..::||||||||||:|||.|||||||||||||..||.|
Frog   141 WLMVELAIIGSDMQEVIGSAIALNLLSAGIIPLWGGVLITIIDTFFFLFLDKYGLRKLEAFFGFL 205

  Fly   222 ITIMAVSFGYEYIVSAPNQGEVLEGMFVPWCSNCNSNVLLQAVGVVGAVIMPHNLYLHSALVKSR 286
            |||||::|||||:..:|||||:|:|||.|:|.:|.:..|.||||:|||||||||:||||||||||
Frog   206 ITIMALTFGYEYVRVSPNQGELLKGMFFPYCKDCGAPQLEQAVGIVGAVIMPHNMYLHSALVKSR 270

  Fly   287 DIDRRQTKKVSEANFYFFIEASVALFVSFIINLFVVAVFAHGMYGKTNNDVVEVCKDKSMYEDAK 351
            :|:|...|:|.|||.|||||:|:|||:||:||:|||||||...|||||.:|...|.:||
Frog   271 EINRANKKEVREANKYFFIESSIALFISFLINVFVVAVFAEAFYGKTNQEVFNECLNKS------ 329

  Fly   352 MSFVDNV--NGTAIIDADLYKGGLFLGCTFGAVAMYIWGVGILAAGQSSTMTGTYAGQFSMEGFL 414
             |...|:  |.|..:..|::|||:.|||.|||.|:|||.||||||||||||||||:|||.|||||
Frog   330 -SPQSNLFPNNTDPLQVDIFKGGVVLGCFFGAPALYIWAVGILAAGQSSTMTGTYSGQFVMEGFL 393

  Fly   415 NLQWPRWCRVLVTRCIAIIPTFCLAMFSKMEDLTSMNDILNAVMSLQLPFAAIPTIAFTSCAAIM 479
            ||:|.|:.||.:||.|||.||..:|:|..::.||.|||.||.:.|||||||.||.:.|||..::|
Frog   394 NLKWSRFARVFLTRSIAITPTLLVAIFQDVQHLTGMNDFLNVLQSLQLPFALIPILTFTSLPSVM 458

  Fly   480 GEFVNGLGNKIVSILLTIVVIGVNLYFVVVQVENMEIKGGLLAL---VCIFAILYILFNLYLVIH 541
            .||.||:|.||...:|.::|..:|:|||||.|..:    |.:|.   ..:.::.|:.|..||...
Frog   459 SEFANGIGWKIAGGILILIVCSINMYFVVVYVSAL----GHIAYYVGAAVLSVAYLCFVAYLTWQ 519

  Fly   542 MAACMG 547
            ....:|
Frog   520 CLVALG 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mvl	NP_001262795.1	nramp	75..479	CDD:162246	274/405 (68%)
Mvl	NP_001262795.1	Nramp	97..486	CDD:279852	256/390 (66%)
slc11a2	XP_012811868.1	nramp	59..458	CDD:162246	274/405 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	518	1.000	Domainoid score	I307
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55471
Inparanoid	1	1.050	609	1.000	Inparanoid score	I908
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252569at33208
OrthoFinder	1	1.000	-	-		FOG0000712
OrthoInspector	1	1.000	-	-		otm48850
Panther	1	1.100	-	-	LDO	PTHR11706
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2295
SonicParanoid	1	1.000	-	-		X461
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190