DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc93AB and DYNC2H1

DIOPT Version :9

Sequence 1:	NP_001262793.1	Gene:	Dhc93AB / 42485	FlyBaseID:	FBgn0013812	Length:	4496	Species:	Drosophila melanogaster
Sequence 2:	NP_001073932.1	Gene:	DYNC2H1 / 79659	HGNCID:	2962	Length:	4314	Species:	Homo sapiens

Alignment Length:	4781	Identity:	1213/4781 - (25%)
Similarity:	2116/4781 - (44%)	Gaps:	903/4781 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LPIPREDCG----NFIIYGDLATRTIDQLSALVEEVLVPLLSNEDNYRNWPIMVAQDVQKHVHSL 159
            |.:.|.|.|    |.|.:||    |.|::  ||...|.|.:..::|..: .|:|:..::..:.||
Human    51 LRVQRSDAGISFSNTIEFGD----TKDKV--LVFFKLRPEVITDENLHD-NILVSSMLESPISSL 108

  Fly   160 KSTVHQVKGQVSGETILAMPVGVEKIVKAAKELVETEQC--QFDLYLKSAIE------GVVIKWA 216
            ...|.||                     .|..|::.::.  .||..|::.:.      |:|::.:
Human   109 YQAVRQV---------------------FAPMLLKDQEWSRNFDPKLQNLLSELEAGLGIVLRRS 152

  Fly   217 -TQIHEV-IKESPSNAFANGQNPTPHTEFTFW------NNRLKNLSFIYDQLRNERIRAMALILE 273
             |.:.:: .||..:....     ||..||.||      .|:         |:..||......:.|
Human   153 DTNLTKLKFKEDDTRGIL-----TPSDEFQFWIEQAHRGNK---------QISKERANYFKELFE 203

  Fly   274 YSMSAYHPCFQTLFKNVVTALAEAKDITLYLNPLKRPLQH--------LEEID--------FAEC 322
            .....::.........||..:...:|:   ::.:.|..:|        |..:|        |.:.
Human   204 TIAREFYNLDSLSLLEVVDLVETTQDV---VDDVWRQTEHDHYPESRMLHLLDIIGGSFGRFVQK 265

  Fly   323 KPLLIPFMNTVGILWGNSRYYC-QSAKITVLLQE----ICNLIIHQA-KRYLDPSSIFHSDIDEA 381
            |      :.|:. ||.:..|.. :|.|..:.:.|    :||.:..|. :||:.     |...:|
Human   266 K------LGTLN-LWEDPYYLVKESLKAGISICEQWVIVCNHLTGQVWQRYVP-----HPWKNE- 317

  Fly   382 MQRLTLSIQILKFFRELFDYYKERLATFFTEPEERPPILWTFHPNSVFKRFNAFLERLTTIQWFF 446
                       |:|.|..|...:||        |....:.|.|...::
Human   318 -----------KYFPETLDKLGKRL--------EEVLAIRTIHEKFLY----------------- 346

  Fly   447 FTVIEFLKLEKVEIGGLRGRQLSTRITDVY-----VEFNQY----FTAFASKSYDVLDPDDHEFD 502
                 ||...:.:|..|      ||:.:.:     |::|.|    :.|..|:...::.|.:.:..
Human   347 -----FLPASEEKIICL------TRVFEPFTGLNPVQYNPYTEPLWKAAVSQYEKIIAPAEQKIA 400

  Fly   503 EDFKGFQTRILELDMKLAAILCQAFDDCHNLESIFKLISIVGSVLDRPKI-KEEFTQRYAEIVRM 566
            ...|.:.:.|.:...:|             |::..|...:|    .||.| ||...:|...:.|:
Human   401 GKLKNYISEIQDSPQQL-------------LQAFLKYKELV----KRPTISKELMLERETLLARL 448

  Fly   567 LDDEMTICESIYDKQMELKK-----VGDNLYP--NYNCPPVAAFIRWCHQLETRITAPVKNFKAL 624
            :|       ||.|.:::.:.     .||...|  ..|...|...|.|..|||.::...:|..:||
Human   449 VD-------SIKDFRLDFENRCRGIPGDASGPLSGKNLSEVVNSIVWVRQLELKVDDTIKIAEAL 506

  Fly   625 QHEITK----TEKSQEIVERYEILMVKLGSCKTQFFDDWAGQLDGQIEEN-------LKKSLIAR 678
            ..::..    .:.:::::::.::.       :.:.||||:..:...:.::       ....::..
Human   507 LSDLPGFRCFHQSAKDLLDQLKLY-------EQEQFDDWSRDIQSGLSDSRSGLCIEASSRIMEL 564

  Fly   679 DRRHNSLILNFSAALFSILREVHYMQQM------KIEGIPQIAIDFAEKSDVFRSYTLNLEKTID 737
            |.....|.:::|..|..:||||..:..:      ||:.:..||..|.:::.:       |::...
Human   565 DSNDGLLKVHYSDRLVILLREVRQLSALGFVIPAKIQQVANIAQKFCKQAII-------LKQVAH 622

  Fly   738 WYNSIQEGSSPVELRLIEPEIKMI-------DDLVEI------GVNQLVW-NSSDILSYLDKLRK 788
            :||||.:       ::|:.:..|:       :.:::.      |.:|:.| |..::..|:.|
Human   623 FYNSIDQ-------QMIQSQRPMMLQSALAFEQIIKNSKAGSGGKSQITWDNPKELEGYIQK--- 677

  Fly   789 PVAALQNRMDHTQGNLRQIRKIMGVWAKQPLFERRDCKKDTVLSIDERPDRTSKRYAEIQAASIE 853
                |||..:......|::||    |      ....|:|..||                    :.
Human   678 ----LQNAAERLATENRKLRK----W------HTTFCEKVVVL--------------------MN 708

  Fly   854 IHKLLQDNMLQFDMESKQDDAVWLSYVDFVDNIVYENILKTVGVSVGYLAENMDPENNYAPLFES 918
            |..|.|....:   :..|:....|:.|:                :.|:.|.:|.....:
Human   709 IDLLRQQQRWK---DGLQELRTGLATVE----------------AQGFQASDMHAWKQH------ 748

  Fly   919 RLELVEPNLVFVPSLDPEDPMGFNNMLIELMRDIMKMGSLIKRLKPNEKRNYVEMIKENQDIIDM 983
                                  :|:.|.:.:....:||              :|.:.||...|:
Human   749 ----------------------WNHQLYKALEHQYQMG--------------LEALNENLPEIN- 776

  Fly   984 RREILNGVDLVMEEAS-RFCRQFERYSYLWLDDREECMEYFLEYGRMLDPDEIELILINDPNQPP 1047
                   :||..::.. :|...||          |...:|:.|..|          .|..|||
Human   777 -------IDLTYKQGRLQFRPPFE----------EIRAKYYREMKR----------FIGIPNQ-- 812

  Fly  1048 PQPCQPTIEAFREQI---------DNYESLFNEIEDIGPFQVFSS-------WF---QVDVRPFR 1093
               .:...||..|.|         ..:.::|::.||:  |:..|:       |.   |||:....
Human   813 ---FKGVGEAGDESIFSIMIDRNASGFLTIFSKAEDL--FRRLSAVLHQHKEWIVIGQVDMEALV 872

  Fly  1094 QALLNTVCKWGNMFK---------EHLVTTVTSSLMNLS---------HFIRKADEGLLQTVKEK 1140
            :..|.||..|...||         |.|.:.|....:|::         ..|:|..:.|:.::|:
Human   873 EKHLFTVHDWEKNFKALKIKGKEVERLPSAVKVDCLNINCNPVKTVIDDLIQKLFDLLVLSLKK- 936

  Fly  1141 DYEGLVSIMAYLMQVKERAAKTDEMFEPMQETIQ-----LLKYYDM-DIPEEVNVLLQELPEQWA 1199
                  ||.|:|.::.....:..|:...|.::::     .|:|..: :...|:..|.||..::..
Human   937 ------SIQAHLHEIDTFVTEAMEVLTIMPQSVEEIGDANLQYSKLQERKPEILPLFQEAEDKNR 995

  Fly  1200 NTKKIASTVKQQVSPLQA----------TEVVSIRNKIALF----ESHIQLF---REVFKTYDFF 1247
            ..:.:|....:.:|.|:|          :..:.|:::|.:.    :|.:|::   .|.||.
Human   996 LLRTVAGGGLETISNLKAKWDKFELMMESHQLMIKDQIEVMKGNVKSRLQIYYQELEKFKA---- 1056

  Fly  1248 RFDCYKP---------YLLMDRIN----------DDMFLCESEMRDIQESGSLFEVNIPEFKVLK 1293
            |:|..||         :..:|:..          ||:   |...:.:.:....|.:..|.|.:..
Human  1057 RWDQLKPGDDVIETGQHNTLDKSAKLIKEKKIEFDDL---EVTRKKLVDDCHHFRLEEPNFSLAS 1118

  Fly  1294 QCRKELRMLKQLWDYV-----NIVATSIDDWKTTPWRKVDVENMDIECKKFAKDIRLLDKEMRPW 1353
            ...|::....|:|.:.     .....:.:||.|                 |.....|.::.:..|
Human  1119 SISKDIESCAQIWAFYEEFQQGFQEMANEDWIT-----------------FRTKTYLFEEFLMNW 1166

  Fly  1354 D-----------TFINLESTV---KNMLTSLRAV-GELQNPAIRERHWNQLMNSTKSLAALPKEV 1403
            .           ..:.|:|.|   |.::..|:.| ||..:|    .||..|..    |..||:
Human  1167 HDRLRKVEEHSVMTVKLQSEVDKYKIVIPILKYVRGEHLSP----DHWLDLFR----LLGLPR-- 1221

  Fly  1404 TVKFIMDHETTLAELLGLNLHECEE-------EVKNIVDKAVKEMSMEKILRDLN-----TTWTV 1456
                    .|:|.:||..:|....:       ::|::..:|..|:::.:.||:|:     ..:|:
Human  1222 --------GTSLEKLLFGDLLRVADTIVAKAADLKDLNSRAQGEVTIREALRELDLWGVGAVFTL 1278

  Fly  1457 MEFDHELHPRTGCNLLKASEELIETLEDNQVCLQNLITSKYIAHFLEEVSTWQNKLMIADQVITV 1521
            :::: :...|| ..|:|..::::..:.||:..||:|..|.|...|.::||.|:.||...|:.:..
Human  1279 IDYE-DSQSRT-MKLIKDWKDIVNQVGDNRCLLQSLKDSPYYKGFEDKVSIWERKLAELDEYLQN 1341

  Fly  1522 WFEVQRTWTHLESIFMSSEDIRKQLPVDSDRFDNIDAEFRVLMDEMSVSSNVVASTNRSGLIERL 1586
            ...:||.|.:||.||.     |..||.:..||:.:|.:||.:|.::...:.|...|..:|:...|
Human  1342 LNHIQRKWVYLEPIFG-----RGALPKEQTRFNRVDEDFRSIMTDIKKDNRVTTLTTHAGIRNSL 1401

  Fly  1587 EHLQKELTLCEKALAEYLETKRLAFPRFYFVSSADLLDVLSNGIQPEMVTKHLTKLFDSIARLKF 1651
            ..:..:|..|:|:|.|:||.||.|||||||:...|||::|.....|.::..||.|||..|..:.|
Human  1402 LTILDQLQRCQKSLNEFLEEKRSAFPRFYFIGDDDLLEILGQSTNPSVIQSHLKKLFAGINSVCF 1466

  Fly  1652 NRDESNEINTASGMYAKDGEYVEFNELASIRGPVEVWLNRIQAAMRASLRHYVMEAVIAYEEKQR 1716
              ||.::..||  |.:.:||.|.|.....:...||.|||.:...|:.:|...:.|.|......|.
Human  1467 --DEKSKHITA--MKSLEGEVVPFKNKVPLSNNVETWLNDLALEMKKTLEQLLKECVTTGRSSQG 1527

  Fly  1717 EQWLFDYPAQVSLCGSQIWWSTEVNIAFSRLEEGYDNAIKDYYKKQISQLSLLITLLLGELSK-- 1779
            ......:|:|:.....||           :..|..:|||||:...||.      |.|:.:|.:
Human  1528 AVDPSLFPSQILCLAEQI-----------KFTEDVENAIKDHSLHQIE------TQLVNKLEQYT 1575

  Fly  1780 ---------GDRQ------KIMTICTIDVHSRDVVAKMIQAKLDSGSAFMWQSQLRHRFDDVEKD 1829
                     |:.:      |:..:....:|:.|||.::.|.::.:...:.|:.|||. :...:..
Human  1576 NIDTSSEDPGNTESGILELKLKALILDIIHNIDVVKQLNQIQVHTTEDWAWKKQLRF-YMKSDHT 1639

  Fly  1830 CFANICDAEFQYCHEYLGNTPRLVITPLTDRCYITLTQSLHLVMGGAPAGPAGTGKTETTKDLGR 1894
            |...:.|:||||.:||.||..:||.|||||:||:||||::.:.:||.|.|||||||||:.|.||.
Human  1640 CCVQMVDSEFQYTYEYQGNASKLVYTPLTDKCYLTLTQAMKMGLGGNPYGPAGTGKTESVKALGG 1704

  Fly  1895 AIGISVYVFNCSEQMDYQSCGNIYKGLAQTGAWGCFDEFNRITVEVLSVVAVQVKSVQDAIRDKK 1959
            .:|..|.||||.|.:|.:|.|.|:.||.:.|||||||||||:...|||.|::|::::|||:::.:
Human  1705 LLGRQVLVFNCDEGIDVKSMGRIFVGLVKCGAWGCFDEFNRLEESVLSAVSMQIQTIQDALKNHR 1769

  Fly  1960 DKFNFMGEMISCVPTVGIFITMNP---GYAGRTELPENLKALFRPCAMVVPDFELICEIMLVAEG 2021
            .....:|:.:......||||||||   ||.||.:||:|||.||||.||..||.|||.|::|.:||
Human  1770 TVCELLGKEVEVNSNSGIFITMNPAGKGYGGRQKLPDNLKQLFRPVAMSHPDNELIAEVILYSEG 1834

  Fly  2022 FQDARVLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKR------GDPGRPEEEVLM 2080
            |:||:||:||.:.::.|.:|||:.|.||||||||:|:||..:|:|.|      ......|..:::
Human  1835 FKDAKVLSRKLVAIFNLSRELLTPQQHYDWGLRALKTVLRGSGNLLRQLNKSGTTQNANESHIVV 1899

  Fly  2081 RALRDFNIPKIITDDMPVFMGLISDLFPALDVPRKRDQDFERTVKQAASDLLLQPEDNFILKVVQ 2145
            :|||...:.|....|...|..||.|:||.:::......:....:||...:...:...|.|.|.::
Human  1900 QALRLNTMSKFTFTDCTRFDALIKDVFPGIELKEVEYDELSAALKQVFEEANYEIIPNQIKKALE 1964

  Fly  2146 LEELLEVRHSVFIVGNAGTGKTQVWK----TLLRTYQNIKRKPIFNDLNPKAVTNDELFGIINPA 2206
            |.|.|..|..|.|||.:|.||:.:|:    .|.:|.:.:|:    ..:||||:...:|.|.|:..
Human  1965 LYEQLCQRMGVVIVGPSGAGKSTLWRMLRAALCKTGKVVKQ----YTMNPKAMPRYQLLGHIDMD 2025

  Fly  2207 TREWKDGLFSVLMRDQANITGDQPKWIVLDGDIDPMWIESLNTVMDDNKVLTLASNERIALTPSM 2271
            ||||.||:.:...|.......|...||:.||||||.||||||:|:|||::||:.|.|||...|::
Human  2026 TREWSDGVLTNSARQVVREPQDVSSWIICDGDIDPEWIESLNSVLDDNRLLTMPSGERIQFGPNV 2090

  Fly  2272 RLLFEISNLRTATPATVSRAGILYINPQDLGWNPYVTSWVETRKIPAE-KSNLVMLFDKYIPPSL 2335
            ..:||..:|..|:|||:||.|:::::.::...|..:.||:  |..||| ::||......|...:|
Human  2091 NFVFETHDLSCASPATISRMGMIFLSDEETDLNSLIKSWL--RNQPAEYRNNLENWIGDYFEKAL 2153

  Fly  2336 ETIRVRFKKITPVAEMAHI----QMLCHLLNCFLIPANTPADCPKEWHELYFVFACIWAFGSAMF 2396
            :.:   .|:...|.|.:.:    ..|.||..|            ::..|  |:...|...|..:
Human  2154 QWV---LKQNDYVVETSLVGTVMNGLSHLHGC------------RDHDE--FIINLIRGLGGNL- 2200

  Fly  2397 QDQAIDYRVEFSK---WWVNEFKTVKFPPG-GTVFDYFLDSETKTFLPWTEKIPKFELDSD---- 2453
               .:..|:||:|   .|..|     .||. ....|.:.||.......:..|.|: :|.:|
Human  2201 ---NMKSRLEFTKEVFHWARE-----SPPDFHKPMDTYYDSTRGRLATYVLKKPE-DLTADDFSN 2256

  Fly  2454 ---LPLQAVIVHTSESIR-LRFFLD-LLMDKKHPVMLVGNAGCGKTVLVNEKLQSLSENYAVTTI 2513
               ||    ::.|.:..| |.:|.. |..|.|.|.:|||..||||.:|:......| .:..:.|:
Human  2257 GLTLP----VIQTPDMQRGLDYFKPWLSSDTKQPFILVGPEGCGKGMLLRYAFSQL-RSTQIATV 2316

  Fly  2514 PFNYYTTS-EMLQKILE--KPLEKKAGRNYGPPGNKLLCYFVDDINMPEVDAYGTVQPHTLMRQH 2575
            ..:..||| .:|||:.:  ..:....||.|.|...:.|..::.|||:|::|.:||......::|.
Human  2317 HCSAQTTSRHLLQKLSQTCMVISTNTGRVYRPKDCERLVLYLKDINLPKLDKWGTSTLVAFLQQV 2381

  Fly  2576 LDYGHWYDRNKLTLKDIHNCQYVACMNPTSGSFTINPRLQRH-----------FCVLAVSFPGPE 2629
            |.|..:||.| |....:.|.|.||.|  ::|.     ||.||           .|  ::.:|..|
Human  2382 LTYQGFYDEN-LEWVGLENIQIVASM--SAGG-----RLGRHKLTTRFTSIVRLC--SIDYPERE 2436

  Fly  2630 SITVMYSSILAQHFANAEQKFTPIVTRMTPN-----IVAATIALHNKCLQVFLPTAIK------S 2683
            .:..:|.:.|           .|::.:...|     ..:....|....:||:.....|      |
Human  2437 QLQTIYGAYL-----------EPVLHKNLKNHSIWGSSSKIYLLAGSMVQVYEQVRAKFTVDDYS 2490

  Fly  2684 HYIFNLRDISNVFQGLLFSSTECLTGSTD-----LIRLWQHETQRVYSDKLTDDKDIDSFTKMQH 2743
            ||.|....::....||.....|  .||::     ::.:..:|.:|::.||:...|::..|
Human  2491 HYFFTPCILTQWVLGLFRYDLE--GGSSNHPLDYVLEIVAYEARRLFRDKIVGAKELHLF----- 2548

  Fly  2744 DIVKKSFEEID-ESVIFD--KPNIYC-----HFAGGIGDP-KYMPIKGWP-------ELHKLLQE 2792
            ||:..|..:.| .|.|.|  ..:.|.     |.:|....| :.:|..|.|       :|..::::
Human  2549 DIILTSVFQGDWGSDILDNMSDSFYVTWGARHNSGARAAPGQPLPPHGKPLGKLNSTDLKDVIKK 2613

  Fly  2793 AMSSYNDLVAAMNLVLFEDAMMHVCRINRILESPRGSALLVGVGGSGKQSLARLAAFISSLEVVQ 2857
            .:..|......::::||.:.:.::.||:|:|..|.||.||.|..|.|::::..|.:.:....:..
Human  2614 GLIHYGRDNQNLDILLFHEVLEYMSRIDRVLSFPGGSLLLAGRSGVGRRTITSLVSHMHGAVLFS 2678

  Fly  2858 IQLKKGYGVNDLKNEFSGLYLKAGLKNVGIMFLMTDAQIPSEDFLVLINDMLATGEIPDLFPDDE 2922
            .::.:||.:...||:...:...||::...::.|:.|.|.....||.:||.:|::||:|.|:..:|
Human  2679 PKISRGYELKQFKNDLKHVLQLAGIEAQQVVLLLEDYQFVHPTFLEMINSLLSSGEVPGLYTLEE 2743

  Fly  2923 IENIIAGVRNEVKGAGLVDTRENCWKFFIDRVRKQLKIVLCFSPVGSTLRVRSRKFPAIINATSI 2987
            :|.::..::::....|....   .:.:|..|:::.|.|||......|...:.....||:.....:
Human  2744 LEPLLLPLKDQASQDGFFGP---VFNYFTYRIQQNLHIVLIMDSANSNFMINCESNPALHKKCQV 2805

  Fly  2988 NWFHEWPQEALISVAMNFLAQ---------NKVLPENHRDSV----AKFMAYVHTSVNTTSKVYL 3039
            .|...|...::..:.....::         .|...|..::||    .|....:|.|    .|.|
Human  2806 LWMEGWSNSSMKKIPEMLFSETGGGEKYNDKKRKEEKKKNSVDPDFLKSFLLIHES----CKAY- 2865

  Fly  3040 QNERRYNYTTPKSYLEQINLYIKLLNHKNEDLQSKIERLENGLEKLRSTALQVADLKVKLAVQEI 3104
                   ..||..|:..:::|..:.:.|.::|..:...|:.|:.||......|.:|..|...|.:
Human  2866 -------GATPSRYMTFLHVYSAISSSKKKELLKRQSHLQAGVSKLNEAKALVDELNRKAGEQSV 2923

  Fly  3105 ELKEKNEAADALIEIVGIETEKVQTEKAVADEEEMKVALIADEVSKKQRDCEEDLLKAEPALMAA 3169
            .||.|.:.|||.::::.:..:....:|...:..:.::|....::.:::...:::|.:.:|.:..|
Human  2924 LLKTKQDEADAALQMITVSMQDASEQKTELERLKHRIAEEVVKIEERKNKIDDELKEVQPLVNEA 2988

  Fly  3170 QDALNTLNKANLTELKSFGSPPGAVTNVTAAVMVLLSQGGKVPKDRSWKAAKIAMAKVDTFLDSL 3234
            :.|:..:...:|:|::|...||..:.::...|:.|:.     ..|.||.:.|..:||... .:.:
Human  2989 KLAVGNIKPESLSEIRSLRMPPDVIRDILEGVLRLMG-----IFDTSWVSMKSFLAKRGV-REDI 3047

  Fly  3235 INYDKENIHPEITKAIQPYL--KDPEFEPEFVRSKSGAAAGLCAWVINIIKFYEVYCDVEPKRKA 3297
            ..:|..||..||.::::..|  ....|:|:..:..|.|||.|.|||...|::..|...:.|....
Human  3048 ATFDARNISKEIRESVEELLFKNKGSFDPKNAKRASTAAAPLAAWVKANIQYSHVLERIHPLETE 3112

  Fly  3298 LAAANAELAAAQDKLAGIKRKVMSLEEQLGKLTADFEKATADKLRCQQEADATQATIALANRLVG 3362
            .|...:.|...:|:...::..:.|:.:::.:|...|:..|::..:.:.|....|.||..|..|:.
Human  3113 QAGLESNLKKTEDRKRKLEELLNSVGQKVSELKEKFQSRTSEAAKLEAEVSKAQETIKAAEVLIN 3177

  Fly  3363 GLASENVRWAEAVNNFVKQGITLPGDILLITAFISYVGCFTKGFRIDLLLKMWTPFLKSIDPPIP 3427
            .|..|:.||...|....::..|||....|..|||:|:....:..| ...|:.||   ||..
Human  3178 QLDREHKRWNAQVVEITEELATLPKRAQLAAAFITYLSAAPESLR-KTCLEEWT---KSAG---- 3234

  Fly  3428 TTENLDPLSLLTDDTTIAIWTNEGLPSDRMSIENATIL-------SNSDRWPLMIDPQLQGVKWI 3485
             .|..|....|..::...||.:||||||.:|||||.::       |.|...|.:|||..|..:|:
Human  3235 -LEKFDLRRFLCTESEQLIWKSEGLPSDDLSIENALVILQIIGLKSWSRVCPFLIDPSSQATEWL 3298

  Fly  3486 KQKYGED-LKVIRLGQRSYLDIIEKSINAGCNVLIENIDENLDPVLDSLLGRNLIKKGK--AIKI 3547
            |....:. |:||.....:::..:|.::..|..::|:.:| .::|||..||.|:|:.:|.  .::|
Human  3299 KTHLKDSRLEVINQQDSNFITALELAVRFGKTLIIQEMD-GVEPVLYPLLRRDLVAQGPRYVVQI 3362

  Fly  3548 GDKEIEYNSNFRLILHTKLANPHYKPEMQAQTTLINFTVTRDGLEDQLLAEVVKAERPDLEELKA 3612
            |||.|:||..|||.|.|:..||...|:..:..|.:|||.||.||..||||..::.|:|||||.|.
Human  3363 GDKIIDYNEEFRLFLSTRNPNPFIPPDAASIVTEVNFTTTRSGLRGQLLALTIQHEKPDLEEQKT 3427

  Fly  3613 DLTKQQNDFKIMLKKLEDDLLSRLSSAGENILGDTALVENLETTKSTASEIEQKVAEAKITSKEI 3677
            .|.:|:.|.||.|.|||:.||..|:::..|||.:..|:|:|..||::::.|::.:.|:......:
Human  3428 KLLQQEEDKKIQLAKLEESLLETLATSQGNILENKDLIESLNQTKASSALIQESLKESYKLQISL 3492

  Fly  3678 DKAREYYRPAAARASLLYFILNELNTINPIYQFSLKAFSVVFQKAIAKAEPGDTLDLRVSNLIDC 3742
            |:.|:.|.|.|..||.:|||:::|:.||.:|:|||.||..:||:|:...:..:..:.|:.:||..
Human  3493 DQERDAYLPLAESASKMYFIISDLSKINNMYRFSLAAFLRLFQRALQNKQDSENTEQRIQSLISS 3557

  Fly  3743 ITYSVFQYTSRGLFECDKLIFASQM---------------TFQILLMNEEVTSAELDFLLRFPIK 3792
            :.:.|::|..|.||:.|:|:||...               ||..:::.:.:..|:    .:..|:
Human  3558 LQHMVYEYICRCLFKADQLMFALHFVRGMHPELFQENEWDTFTGVVVGDMLRKAD----SQQKIR 3618

  Fly  3793 PHVTSPVDFLTNQSWG-GICSLASKDEFRNLDRDIETSSKRWKKLVESELPEKEKFPQEWKNKTA 3856
            ..:.|.:|  ..:||. ....:|....::.|..:   .:..|:....:.:.|:| ||.....|.:
Human  3619 DQLPSWID--QERSWAVATLKIALPSLYQTLCFE---DAALWRTYYNNSMCEQE-FPSILAKKVS 3677

  Fly  3857 L-QRLCMIRALRPDRMTYALADFIEEKLGSKYVESRAMEFAKSYEEASPSTPIFFILSPGVNPLK 3920
            | |::.:::||||||:..|:|.|..:.||.|.|....:...:.|:|.....||..|:|||.:|.:
Human  3678 LFQQILVVQALRPDRLQSAMALFACKTLGLKEVSPLPLNLKRLYKETLEIEPILIIISPGADPSQ 3742

  Fly  3921 DVEALGKQMGFSMDLGN-------FHNVSLGQGQEAIAEAAMDTAAKHGHWVVLQNIHLVRKWLP 3978
            :::          :|.|       :|.|::||||..:|...:...|::|.|:.|:|:|||..|||
Human  3743 ELQ----------ELANAERSGECYHQVAMGQGQADLAIQMLKECARNGDWLCLKNLHLVVSWLP 3797

  Fly  3979 VLEKKLE-YYAEDSHPDYRMFLSAE--PASTPSAHIIPQGILESSIKITNEPPTGMLANLHKALD 4040
            ||||:|. ...:|:   :|::|:||  |..||.       :|:||:|||.|.|.|:..||.:..:
Human  3798 VLEKELNTLQPKDT---FRLWLTAEVHPNFTPI-------LLQSSLKITYESPPGLKKNLMRTYE 3852

  Fly  4041 NFTQETLEMSGKEAEFKA-ILFSLCYFHAVVAERRKFGPQGWNKIYPFNVGDLNISVSVLYNYLE 4104
            ::|.|  ::|.|:...:| .||||.:|||...|||.:.||||.|.|.|::.||....:::....:
Human  3853 SWTPE--QISKKDNTHRAHALFSLAWFHAACQERRNYIPQGWTKFYEFSLSDLRAGYNIIDRLFD 3915

  Fly  4105 ANAKVPWEDLRYLFGEIMYGGHITDDWDRRLCITYLEEYMQPDLVD-----GELFLAP-SFPAPP 4163
            ....|.||.:..|....:|||.|.:.:|.|:..:||:::....::|     .:..:.| |...|.
Human  3916 GAKDVQWEFVHGLLENAIYGGRIDNYFDLRVLQSYLKQFFNSSVIDVFNQRNKKSIFPYSVSLPQ 3980

  Fly  4164 NTDYQGYHTYVDEMMPAESPYLYGLHPNAEIGFLTTRAENIFRTVFEMQPRDAGAG--GGATVTR 4226
            :.....|...::::...:.|..:||..|     :...::.:..:....|.|..|..  .|:...|
Human  3981 SCSILDYRAVIEKIPEDDKPSFFGLPAN-----IARSSQRMISSQVISQLRILGRSITAGSKFDR 4040

  Fly  4227 E---DKVKQIVDEIIEKLPEEFNMVEIMNKV---EERTPYVIVAFQECERMNF--LTSEMKRSLK 4283
            |   :::..::: :.:||.:..|::.  .||   .:|....|::|...|:.|.  |...:.:||.
Human  4041 EIWSNELSPVLN-LWKKLNQNSNLIH--QKVPPPNDRQGSPILSFIILEQFNAIRLVQSVHQSLA 4102

  Fly  4284 ELDLGLKGELTITSDMEVLENSLFLDQVPPIWTQR-------------AYPSLLGLNNWFIDLCL 4335
            .|...::|...::|:::.|.::|...:.|..|..:             .....|.:.||
Human  4103 ALSKVIRGTTLLSSEVQKLASALLNQKCPLAWQSKWEGPEDPLQYLRGLVARALAIQNW------ 4161

  Fly  4336 RLRELETWSTDFVLPSCVWLAGFFNPQSLLTAIMQSTARRNDLPLDKMCLQCDVTKKQKEEFTTA 4400
                ::......:|...:.|:..|:|.:.|.|:.|.|||.....:|.:........:.:|.....
Human  4162 ----VDKAEKQALLSETLDLSELFHPDTFLNALRQETARAVGRSVDSLKFVASWKGRLQEAKLQI 4222

  Fly  4401 PRDGCCVHGIFMEGARWDIQQGIIMESRLKELYPSMPVINIRAITQDKQDLRNMY---EC---PV 4459
            .     :.|:.:||..:|..|  :.|::|..  ||:..:....:....||....|   ||   ||
Human  4223 K-----ISGLLLEGCSFDGNQ--LSENQLDS--PSVSSVLPCFMGWIPQDACGPYSPDECISLPV 4278

  Fly  4460 YKTRTRGPTTYVSNLNLKTKDKPGKWILAGVALLLQ 4495
            |.:..|  ...|:|:::.......:||..|.||.|:
Human  4279 YTSAER--DRVVTNIDVPCGGNQDQWIQCGAALFLK 4312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc93AB	NP_001262793.1	DHC_N1	204..782	CDD:285571	119/661 (18%)
		DHC_N2	1295..1708	CDD:285579	119/444 (27%)
		P-loop_NTPase	1841..2071	CDD:304359	124/238 (52%)
		P-loop_NTPase	2155..2290	CDD:304359	58/138 (42%)
		P-loop_NTPase	2448..2720	CDD:304359	77/310 (25%)
		P-loop_NTPase	2797..3064	CDD:304359	61/279 (22%)
		MT	3076..3419	CDD:289543	82/344 (24%)
		AAA_9	3447..3659	CDD:289547	90/221 (41%)
		Dynein_heavy	3799..4486	CDD:281078	185/734 (25%)
DYNC2H1	NP_001073932.1	Stem. /evidence=ECO:0000250	1..1650		399/1959 (20%)
		DHC_N1	162..639	CDD:285571	110/598 (18%)
		DHC_N2	1120..1519	CDD:285579	119/444 (27%)
		P-loop_NTPase	1651..1881	CDD:304359	123/229 (54%)
		AAA 1. /evidence=ECO:0000250	1651..1875		121/223 (54%)
		P-loop_NTPase	<1937..>1988	CDD:304359	16/50 (32%)
		AAA 2. /evidence=ECO:0000250	1938..2161		82/231 (35%)
		AAA_5	1974..2110	CDD:285029	59/139 (42%)
		AAA 3. /evidence=ECO:0000250	2251..2505		71/279 (25%)
		P-loop_NTPase	2285..2494	CDD:304359	60/230 (26%)
		AAA 4. /evidence=ECO:0000250	2617..2863		55/252 (22%)
		P-loop_NTPase	2618..>2829	CDD:304359	48/213 (23%)
		Stalk. /evidence=ECO:0000250	2881..3169		63/293 (22%)
		MT	2897..3229	CDD:289543	80/338 (24%)
		AAA_9	3253..3474	CDD:289547	90/221 (41%)
		Dynein_heavy	3622..4303	CDD:281078	186/737 (25%)
		AAA 6. /evidence=ECO:0000250	3697..3912		83/236 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810