DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dhc93AB and dhc-4

DIOPT Version :9

Sequence 1:NP_001262793.1 Gene:Dhc93AB / 42485 FlyBaseID:FBgn0013812 Length:4496 Species:Drosophila melanogaster
Sequence 2:NP_001338793.1 Gene:dhc-4 / 189209 WormBaseID:WBGene00012272 Length:2727 Species:Caenorhabditis elegans


Alignment Length:3286 Identity:566/3286 - (17%)
Similarity:1073/3286 - (32%) Gaps:1043/3286 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   769 VNQLVWNSSDILSYLDKLRKPVAALQN-----------RMDHTQGNLRQIRK--------IMGVW 814
            |.|..|:.   |:|.|:||:....:..           .....:...|::|:        :..:|
 Worm    25 VEQKSWHQ---LAYEDRLRRESRKIPKICRKQFLKWHVEQQEAKKKFRRLREKNRDESIYVAKLW 86

  Fly   815 ----AKQPLFERRDCKKDTVLSIDERPDR----------TSKRYAEIQAASIEIHKLLQDNMLQF 865
                .|.||..|.:.....|..:..:.:|          .::|||.|:..:....|.::|.:.:.
 Worm    87 YYVLKKHPLKPRVEWSFQRVHKLSPKNERIAQELEELMDCAERYALIENVADGYQKRVKDELARL 151

  Fly   866 DMESKQDDAVWLSYVDFVDN----IVYENILKTVGVSVGYLAENMDPENNYAPLFESRLELVEPN 926
            :...|        |...|.|    ::....|..:.:.:.:       ||....:||.. ||::|.
 Worm   152 NKIEK--------YHHHVKNNREILLRSQSLAAMKIRIFF-------ENRKGLIFEVN-ELIDPE 200

  Fly   927 LVFVPSLDPEDPMGFNNMLIELMRDI-----------MKMGSLIKRLKPNEKRNYVE--MIKENQ 978
            :              .|:.|:..|::           :.|..|.|..:..:|||.|:  :::|..
 Worm   201 V--------------GNIPIKKFREVTLTKVLEFSQEINMKLLKKNWRDEKKRNIVQNCIVQETT 251

  Fly   979 D-------------------------IIDMRREILNGVD---LVMEEASRFC-----RQFERYSY 1010
            :                         |:| |:..:|...   |:.|..|..|     |.......
 Worm   252 NAAFGTIQAYLKTLRNKPAFLSIDCMIVD-RKLWVNSEQIRLLLKEPISVMCALENVRMSTEDCE 315

  Fly  1011 LWLDDREECMEYFLEYGRMLDPDEIELILINDPNQPPPQPCQPTIEAFREQIDNY--------ES 1067
            .|.::...|:|....          |||:.:           |.|:.:...||:|        |.
 Worm   316 TWQEEAMICVEVLSH----------ELIVHH-----------PFIQPYAFLIDDYKVSPKLTEEE 359

  Fly  1068 LFNEIEDIGPFQV------------------FSSWFQVD--VRPFRQALLNTVCKWGNMFKEHLV 1112
            |....:|....|:                  .|.|.:||  :|.||           |..|..:.
 Worm   360 LIKMYDDSTHLQIRLTKAVKLLTIRCFVLRLESVWSEVDRRIRSFR-----------NQLKMAIR 413

  Fly  1113 TTVTSSLMNLSHFIRKADEGLLQTVKEKDYEGLVSIMAYLMQVKERAAKTDEMFEPMQETIQLLK 1177
            ...|:.|..|.|..||.|..|       .|..:...|     :....|:.|.|.:          
 Worm   414 RKFTTLLNKLLHDFRKYDRAL-------QYRSIDPSM-----MLSNKAQVDLMLQ---------- 456

  Fly  1178 YYDMDIPEEVNVLLQELPEQWANTKKIASTVKQQVSPLQA-TEVVSIRNKI-ALFESHIQLFREV 1240
                   .|:...:::..|.:....:|...:....|.|.. .::.|:|..: .....|...|::.
 Worm   457 -------NEIGDSVRQFVEVYDKVFEITQHISLDTSQLDTLLQLASLRLSLPQCINDHAHFFQKR 514

  Fly  1241 FKTYDFFRFDCYKPYLLMDRINDDMFLCESEMRDIQESGSLFEVNIPEFKVLKQCRKELRMLKQL 1305
            ..|  |..|...|...:|..:...|    .:::.:|..|:..||:    ..|.|..|...||..|
 Worm   515 IST--FLHFVTKKQSKVMSNVQKAM----EKLKIVQTMGNPQEVD----NYLTQMAKLRPMLDNL 569

  Fly  1306 WDYVNIVATSIDD---WKTTPWRKVDVENMDI-ECKKFAKDIRLLDK----------------EM 1350
                   .|.|:|   ::|.    ||::..|: :.:.|..:|..|..                |.
 Worm   570 -------ITEIEDLNKFETA----VDIQVSDVTKMRHFVGEIGSLQSLFEATSGYYKHVNAFFES 623

  Fly  1351 RPWDTFINLE-------------STVKNMLTSLRAVGELQNPAIRERHWNQLMNSTKSLAALPKE 1402
            |  .|.:|::             |..::.||:.||.......|..|      :::.|...|:.:.
 Worm   624 R--RTLVNIDASRNFIDQFTIQLSIFESSLTTHRAAKHFIAYARNE------VDAFKKNFAVAEV 680

  Fly  1403 VTVKFIMD-HETTLAELLGLNL---------HECE-------EEVKNIVDKAVKEMSMEKILRDL 1450
            ::.:.::| |...::|::|.:|         ..||       :::|.|...|.:|.:....|..:
 Worm   681 MSCRRLLDAHWLRMSEIVGFDLTPYANSSIAQICELGLEAHLQQLKPIAFSAEREATAADQLHAI 745

  Fly  1451 NTTWTVMEFDHELHPRTGCNLLKASEELIETLEDNQVCLQNLITSKYIAHFLEEVSTWQNKLMIA 1515
            .|.|:....:...:.:...:|.....||...::::...|:::...:.|..  :.:..|......|
 Worm   746 VTFWSQEPLEMRCYVQWKLSLALKLSELHHRVQNDINTLKHMTNVEQITD--DSLPQWIEWTARA 808

  Fly  1516 DQVITVWFEVQRTWTHLESIFMSSED-IRKQ---LPVDSDRFDNIDAEFRVLMDEMSVSSNVVAS 1576
            ::::..|.|.|:.|..:.:||::..| ::|:   |...:..|  |..|..||.||....      
 Worm   809 EKILKAWCETQQKWMRVANIFVTCRDTLQKEYELLRTCAKYF--IKIERNVLKDETIYR------ 865

  Fly  1577 TNRSGLIERLEHL----QK---ELTLCEKALAEYLETKRLAFPRFYFVSSADLLDVLSNGIQPEM 1634
                  :.:|.||    ||   .:::..:.:...|:..|:...|....|...||::.|.......
 Worm   866 ------VMQLPHLPCWIQKINSMVSIIIQGVRGLLDGMRMNNARLCLSSEVHLLNLFSTTSIETR 924

  Fly  1635 VTKHLTKLFDSIARLKFNRDESNEINTASGMYAKDGEYVEFNELASIRGPVEVWLNRIQAAMRAS 1699
            :...|...|.|:.||.|||  .|::.....:..|....:..:|:.| :.|.|: :..|:.|..:.
 Worm   925 LKLLLKDCFPSLRRLCFNR--RNQLEMVDLLEEKVTVDLTKSEIES-QEPCEL-IRSIEQAFASK 985

  Fly  1700 LRHYVMEAVIAYEEKQREQWLFDYPAQVSLCGSQIWWSTEVN-----IAFSRLEEGYDNAIKDYY 1759
            |..     :|.||.:.|.:       ..|..|:.:....|..     :..||:|       |.||
 Worm   986 LTD-----IITYERQDRSK-------AASRVGANVAELIETRQTLDPLFLSRVE-------KTYY 1031

  Fly  1760 --KKQISQLSLL--------------------------ITLLLGELSKGDRQKIMTI--CTID-- 1792
              .:.:.:.|||                          |.||:||:. ..|..::.:  |...  
 Worm  1032 IQHRSVQRQSLLTVDFVYSTEINRFIPRSLADSWSSGHIVLLIGEMC-STRSFVLRLANCMCSNL 1095

  Fly  1793 --VHSRDVVAKMIQAKLDSGSAF-MW----------QSQLRHRF-------------------DD 1825
              |:|..::......::..|.|. .|          .|||..:.                   |:
 Worm  1096 RIVNSHQLLEPAFLERVTKGIAMSSWFVLLENVDLLDSQLIFKLFKILASQVTSFPRLFLSSTDE 1160

  Fly  1826 VEKDCFANICDAEFQYCHEYLGNTP--RLVITPLTDRCYITLTQSLHLVMGGAPAGPAGTGKTET 1888
            ::.....||........||::..:|  :...:||:.    ..|.|:..:    ||....||:..:
 Worm  1161 IKNQLPTNIAVEHLGVFHEFVEVSPAFKFETSPLSS----VRTSSIPKL----PAQLVSTGQPPS 1217

  Fly  1889 TKD--LGRAIGISV---YVFNCSEQMDYQSCGNIYKGLAQTGAWGCFDEFNRITVEVLSVVAVQV 1948
            :..  |...||..:   .:..|...:..::.....:...:...|...|.|               
 Worm  1218 SPHSVLLEKIGAKIRNREISGCVGSLAKETLKETLQNFPEKIIWVYTDVF--------------- 1267

  Fly  1949 KSVQDAIRDKKDKFNFMGEMISCVPTVGIFITMNPGYAGRTELPENLKALFRPCAMVVPDFELIC 2013
              |:|.:..:.|:|       :...:..:|..::|...|.......     |.....:....:..
 Worm  1268 --VRDQMVTRSDEF-------AATQSGILFEVLSPATTGNGGSDSE-----RSYHSTISTSSVTI 1318

  Fly  2014 EIMLVAEGFQDARVLARKFITLYTLCKELLSKQDHYD---------------WGLRAIKSVLVVA 2063
            ..::|..||.:       |..::.....|..|:|.|.               |....::.::.: 
 Worm  1319 NTIVVFYGFSE-------FWNIFPFISPLFLKKDGYSAQTPPFLTLDDGSTYWPQENVQFLMCI- 1375

  Fly  2064 GSLKRGDPGRPEEEVL-MRALRDFNIP-KIITDDMPVFMGLISDLFPALDVPRKRDQDFERTVKQ 2126
                      |:||.. :..::.|:|| .::.:::            .:||.|.           
 Worm  1376 ----------PDEEGFHLNTVKKFDIPFHVVNENL------------KMDVARS----------- 1407

  Fly  2127 AASDLLLQPEDNFILKVVQLEELLEVRHSVFIVGNAGTGKTQVWKTLLRTYQNIKRKPIFNDLNP 2191
                                                       |    |...:.|...:||.::.
 Worm  1408 -------------------------------------------W----RKVWHKKYTELFNKISL 1425

  Fly  2192 KAVTNDELFGIINP------ATREWKDGLFSVLMRDQANITGDQPKWIVLDGDIDPMWIESLNTV 2250
            ..:.::.:..|::|      :|..|...||.|:..|                         |..|
 Worm  1426 VEIMDELVDRILSPMASHFKSTFLWPSTLFQVIYHD-------------------------LTEV 1465

  Fly  2251 MDDNKVLTLASNERIALTPSMRLLFEISNLRTATPATVSRAGILYINPQDLGWNPYVTSWVETRK 2315
            :..:::.::  |:.:.:|                 ..::.|..:.|...|.|            |
 Worm  1466 IPTSRITSV--NDTLRIT-----------------VVLATANFISIFADDQG------------K 1499

  Fly  2316 IPAEKSNLVMLFDKYIPPSLETIRVRFKKITPVAEMAHIQMLCHLLNCFLIPANTPADCPKEWHE 2380
            :           :||:..:|..||          |...|||              |.|       
 Worm  1500 V-----------EKYMGRALGAIR----------EKLSIQM--------------PDD------- 1522

  Fly  2381 LYFVFACIWAFGSAMFQDQAIDYRVEFSKWWVNEFKTVKFPPGGTVFDYFLDSETKTFLPWTEKI 2445
                 .|.|...   :||.....|      |.:|                         |:.:. 
 Worm  1523 -----ICNWKIS---YQDATKLVR------WEDE-------------------------PFCQS- 1547

  Fly  2446 PKFELDSDLPLQAVIVHTSESIRLRFFLDLLMDKKHPVMLVGNAGCGKTVLVNEKLQSLSENYAV 2510
               .:|.|..:..:::.|....||.|:...|:...|.:::.|.....||:.|....:.||.....
 Worm  1548 ---SIDKDSAIGNIMIVTPNMDRLLFYSIRLLASGHNILVHGPPYSRKTMFVKMISKFLSSTVGD 1609

  Fly  2511 TTIPFNYYT-TSEMLQKILEKPLEKKAGRNYGPPGNKLLCYFVDDINMPEVDAYGTVQP-HTLMR 2573
            .|:.|.:.. .|.:...:.:|......|.......:|.| |.|       :|.:...:| ..::.
 Worm  1610 LTVEFLWLDGKSRVGNDVAQKKFADVVGTCERAHQSKQL-YIV-------IDRFSFTEPLLPIIE 1666

  Fly  2574 QHLDYGHWYDRNKLTLKD----------------IHNCQ-----YVACMNPTSGSF-TINPRLQR 2616
            ..:|:..::...||...|                :|..:     :|....|.|..| ...|.:| 
 Worm  1667 FFVDHKTYWKDGKLCNSDAQIRMIIITDEEDYAWLHKTKALASTFVGIAMPASTKFKDQKPLVQ- 1730

  Fly  2617 HFCVLAVSFPGPESITVMYSSILAQHFANAEQKFTPIVTRMTPNIVAATIALHNKCLQVFLPTAI 2681
              .::|.:|.. :|.:..|..||        :.|:..:..:                       :
 Worm  1731 --SLIAANFTA-KSFSSEYHHIL--------ESFSSCIVEI-----------------------V 1761

  Fly  2682 KSHYIFNLRDI---SNVFQGLLFSSTECLTGSTDLIRLWQHETQRVYSD---------------K 2728
            :..|:.||..:   :.:.:...|:..:.......|:||:.||:.||..|               .
 Worm  1762 RKPYVENLSSMALATRLAKSFFFAFPDNCPDPDALLRLFIHESARVIGDAIDPIHRATFAQQFET 1826

  Fly  2729 LTDDKDIDSFTKMQHDIVKKSFEEIDESVI----------FDKPNIYCHF-AGGIGDP-KYMPIK 2781
            |.|:....:|..:...|.:.|.||.:|..:          ||.  ||... |..:.|. .|.|:.
 Worm  1827 LIDENFNTAFQAILKHIAQISEEEEEEEGVEKRMTASLDMFDL--IYSEVDAHDVVDGLAYEPVV 1889

  Fly  2782 GWPELHKLLQEAMSSYNDLVAAMNLVLFED--AMMHVCRINRILESPRGSALLVGVGGSGKQSLA 2844
            ...:..:.::..:..::.......:.||.|  ....|.|:.|::.......:|.....||:..:.
 Worm  1890 DRVQFQRSIENFLFEHHRNHTKDRVRLFVDWETSGWVQRVMRVIRQASEHMVLTAPPNSGRTQVV 1954

  Fly  2845 RLAAFISSLEVVQIQLKK--------------GYGVNDLKNEFSGLYLKAGLKNVGIMFLMTDAQ 2895
            :.|....:..::.:|:..              ...:|.:.|....:.:   |.::...:...:.:
 Worm  1955 KAACVACNATMMHMQVDATCYDTFISRWEYALSRAINIIANTNQHVVI---LVHLDFCYEKVEPR 2016

  Fly  2896 IPSEDFLVLINDMLATGEIPD---LFPDDEIENIIAGVRNEVKGAGLVDTRENCWKFFIDRVRKQ 2957
            ...:..|.:        |.|:   |..|:::..:         |..|::..:|        :..|
 Worm  2017 WMEQIKLWI--------ECPNTQHLVSDEQLHTM---------GEQLIECEKN--------LATQ 2056

  Fly  2958 LKIV--------LC-FSPVGSTLR--------VRSRKFPA-----IIN---ATSINW---FH--E 2992
            ::.:        :| :.|| .||:        :.:|.|.|     :::   .|..:|   ||  .
 Worm  2057 MQTIGLRLPGQRMCKYLPV-ETLKEPQALRKVLEARIFDALHVMFLVDPQFKTDFSWCTIFHVPT 2120

  Fly  2993 WPQEALISVAMNFLAQNKVLPENHRDSVAKFMAYVHTSVNTTSKVYLQNERRYNYTTPKSYL-EQ 3056
            ..:..|:|.....::..||      |..|:.:......|    |.|||:.....|.|..|.| |.
 Worm  2121 IEKSELLSKVSKIISDCKV------DEAAQIIVSTFFIV----KKYLQSIGIALYGTVFSQLFEV 2175

  Fly  3057 INLYIKLLNHKNEDLQSKIERLENGL------EKL---------RSTALQVADLKVKLAVQEIEL 3106
            .:.:..:...:.::|.::..||...|      |||         .:...::.:.:..|:....|.
 Worm  2176 ADCFQIVFREQKKELVAEGTRLNEALHTCEQIEKLAEMGKEVDIEAVQRRIVEKETMLSKMNRER 2240

  Fly  3107 KEKNEAADALIEIVGIETEKVQTEKAVADEEEMKVALIADEVSKKQ---RDCEEDLLKAEPALMA 3168
            ..|....:.|.|:|.::...::|.:  |:|..:|..:.| .||..|   |.|.|:|||      .
 Worm  2241 NTKGARMEVLSELVAVKATNLETMR--AEEAALKTTVEA-MVSAPQEEFRKCVEELLK------F 2296

  Fly  3169 AQDALNTLNKANLTELKSFGSPPGAVTNVTAAVMVLLSQGGKVPKDRSWKA--AKIAMAKVDTFL 3231
            :...:.||:|.         :.|.....:...::..:.:....||..:.:|  ..:.......|.
 Worm  2297 SNTDIKTLSKI---------TKPSVGIRLCCEMLRTIFEPNFKPKRHAAEAWTESLKFVSDKAFF 2352

  Fly  3232 DSLINYDKENIHPEITKAIQPYLKDPEFEPEFVRSKSGAAAGLCAWVINIIKFYEVYCDVEPKRK 3296
            ..|...|.:.:..:..|.::.|:...||....:..:|...|.||.|   |..|.|:.|       
 Worm  2353 IKLATCDADILTVDQMKVLKKYVDRAEFNANKIEHESVVCACLCRW---IGAFLELAC------- 2407

  Fly  3297 ALAAANAELAAAQDKLAGIKRKVMSLE---EQLGKLTADFEKATADKLRCQQEADATQATIA--- 3355
            .|.....::..:::....|::..:..|   .::.:|.:|.||.|. .:|..::..|....:.   
 Worm  2408 TLRVMEEQVEESKELREHIRQTEVRFENESSEMQQLKSDVEKLTV-LIRENEQVLANDRRLCDYR 2471

  Fly  3356 -LANRLVGGLASENVRWAEAVNNFVKQGITLPGDILLITAFISYVGCFTKGFRIDLLLKMWTPFL 3419
             .:..|:..|.....||...:....|:...|.|:.||.....:::.|..|...: :.:.|.|..|
 Worm  2472 LRSGDLLAALEPHRKRWKSQLKQNEKKQKELVGNTLLFAIHRAHLLCQEKAVTL-ICVSMCTSHL 2535

  Fly  3420 KSIDPPIPTTENLDPLSLLTDDTTIAIWTNEGLPSDRMSIENATI--LSNSDRWPLMI---DPQL 3479
                    |::|:.      .|:::|..:|         :.|..:  |.:|.|:.|.:   |..|
 Worm  2536 --------TSQNVQ------FDSSMASSSN---------VINRILRTLKSSRRFCLFLSTTDSLL 2577

  Fly  3480 QGVKWIKQKYGEDLKVIRLGQRSYLDI--------------IEKSINAGCNVLIENIDENLDPVL 3530
            |.|:.:            |...:||||              ::|.:.:....:..|:.|...|.:
 Worm  2578 QNVRSV------------LPGATYLDISPPLTWKEPQMAVSLQKHVYSIVPTVFYNLTEVPPPEM 2630

  Fly  3531 DSLLGRNLIKKGKAIKIGDKEIEYNSNFRLILHTKLANPHYKPEMQAQTTLINFTVTRDG-LEDQ 3594
            ..:|          :|..:||:.|               |.||.......|..|.....| :.||
 Worm  2631 YEIL----------MKSEEKEVCY---------------HNKPLELPDDILFVFVAKNLGHIPDQ 2670

  Fly  3595 L--LAEVV-------------KAERPDLEELKADLT 3615
            :  |.||:             |.||.:|..|..:.|
 Worm  2671 IRKLMEVIVVSIPLEPIEDREKIERNELSSLLGEFT 2706

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dhc93ABNP_001262793.1 DHC_N1 204..782 CDD:285571 4/12 (33%)
DHC_N2 1295..1708 CDD:285579 93/473 (20%)
P-loop_NTPase 1841..2071 CDD:304359 35/251 (14%)
P-loop_NTPase 2155..2290 CDD:304359 17/140 (12%)
P-loop_NTPase 2448..2720 CDD:304359 50/298 (17%)
P-loop_NTPase 2797..3064 CDD:304359 51/316 (16%)
MT 3076..3419 CDD:289543 72/369 (20%)
AAA_9 3447..3659 CDD:289547 41/204 (20%)
Dynein_heavy 3799..4486 CDD:281078
dhc-4NP_001338793.1 DHC_N2 599..990 CDD:369852 81/423 (19%)
SMC_prok_A <2413..>2502 CDD:274009 14/89 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5245
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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