Protein Alignment Rlip and ARHGAP29

DIOPT Version :9

• Sequence 1: NP_650933.2
• Gene: Rlip / 42484
• FlyBaseID: FBgn0026056
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_001315593.1
• Gene: ARHGAP29 / 9411
• HGNCID: 30207
• Length: 1261
• Species: Homo sapiens
• Alignment Length: 475
• Identity: 101/475 - (21%)
• Similarity: 181/475 - (38%)
• Gaps: 109/475 - (22%)

  Fly   186 VFGVSVSLATERSRCHDGVDIPLVVRDCIDFLQDHLKCEQ-IYKIEPIKTRLMHFKRLYNNREHD 249
            :||...:...::.  .||  ||.:::.|...:::...|.| ||::...|.:.....:...|..|.
Human   668 LFGAEFTQVAKKE--PDG--IPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHL 728

  Fly   250 SAVDELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAELQQ------------ 302
            ..:.|.:....|.:|||:||:||||.:...|...|.::|...:...::.|.::
Human   729 VDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMC 793

  Fly   303 ------------LLEQLPKCNRTLLAWVLLHFDAVIQQERHNKLNAQSLAMLLSPTL----QMSH 351
                        ||.|||..|...|.::::|...|:.....||:|:::|.::..|:|    ..:.
Human   794 IEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTA 858

  Fly   352 RLMVALLCHCNNLFADVQLIKYVPPLTSTSPKLPD---TPEDIQTELRKQDS------LLS---- 403
            .:.::.|...:|   ..:|:::   |.:.|.|:.|   .|:|:...:...|.      |||
Human   859 PITISSLAEYSN---QARLVEF---LITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEER 917

  Fly   404 QIHSEMNAGFITKKR-------EEQLWEVQRIITQLKRKLRTF--------EKKQEKTAEEVDNS 453
            .|...|.:.|.:.|.       |.:::|......:.:||....        :|.|....:|.:::
Human   918 DIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESA 982

  Fly   454 SSAPPAVASEDTTDSKPAGTPAVSTNNSISQEEPKT---------DTLTPKDAPNDFTIDPSTGF 509
            |.     ..||....||....:..:.|::.:..|:|         |.|.....||:.. ..:.|.
Human   983 SQ-----KIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERN-GRNMGN 1041

  Fly   510 ILLPK--SNPHRENLLR------------------LQIEYDELMEWQNELKARI------VAERN 548
            :.|.|  .||..|.:.|                  ||...|:..| ||.|.|:.      ..:..
Human  1042 VNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKIQDKQYE-QNSLTAKTTMIMPSALQEK 1105

  Fly   549 EVYRLKQLYEQQSINSQMAS 568
            .|....|:....|||:...|
Human  1106 GVTTSLQISGDHSINATQPS 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	46/209 (22%)
ARHGAP29	NP_001315593.1	BAR	220..436	CDD:299863
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..501
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	541..600
		C1	612..657	CDD:197519
		RhoGAP_PARG1	669..881	CDD:239874	48/221 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	981..1011		6/34 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1117..1153		4/9 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1178..1238
		Interaction with PTPN13/PTPL1. /evidence=ECO:0000269|PubMed:9305890	1258..1261

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910