DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rlip and AGD2

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_176283.1	Gene:	AGD2 / 842378	AraportID:	AT1G60860	Length:	776	Species:	Arabidopsis thaliana

Alignment Length:	715	Identity:	138/715 - (19%)
Similarity:	226/715 - (31%)	Gaps:	259/715 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDSPEEKEFPGLYASEAADAKSRKSKEESDFSEDHDHSKKDLLIGRRKDKKEKGKDRGYAALE 65
            |..|..|.||             ||:..:::..|.|.         .|.|....|...||....|
plant   112 MTVDLQEAKE-------------SRRRFDKAVHSYDQ---------AREKFVSLKKNTRGDIVAE 154

  Fly    66 GESSPEEELDTKSPSKSKKSKTFKFTSS----KSKEKREKSRDKSEKDSKH-----------AEE 115
                .||:|: .|.|..:||: |...:|    ::|:|.|.....|.....|           ::.
plant   155 ----LEEDLE-NSKSAFEKSR-FNLVNSLMTIEAKKKYEFLESISAIMDSHFKYFKLGYDLLSQL 213

  Fly   116 EPSVSHKV-----KEKERDK-EKDRDEPK----KKDKEEKRKEKDKKADKKD-----------KK 159
            ||.: |:|     :.||:.| |:||...:    :...|...::...|||..|           :|
plant   214 EPYI-HQVLTYAQQSKEQSKIEQDRFAQRIQEFRTQSELDSQQASAKADPSDVGGNHVYRAIPRK 277

  Fly   160 DKKSKQLSQQQDDVSAAEEVLALGYPVFGVSVSLATERSRCHDGVDIPLVVRDCIDFLQDHLKCE 224
            :.::..:|      :|.:||...|| :...|.||..:..|..              |:.|:....
plant   278 NVEANSVS------TADKEVTKQGY-LLKRSASLRADWKRRF--------------FVLDNHGSL 321

  Fly   225 QIYKIEPIKT-RLMH---------------FKRLYNNREHDSAVDELNLPTACSLLKLFLRELPE 273
            ..|:....|: :..|               |:..:|......::|...:....||:||...:
plant   322 YYYRNTGNKSAKSQHYYSGLGEHSSGVFGRFRTRHNRSASQGSLDCNMIDLRTSLIKLDAED--- 383

  Fly   274 PLLTTDLVARFEEVASHPKVTTQQAELQQLLEQLPKCNRTLLAWVLLHFDAVIQQERHNKLNAQS 338
                |||...| .:.|..|..|.|||          .....:.||             ||:.|
plant   384 ----TDLRLCF-RIISPQKTYTLQAE----------NGADRMDWV-------------NKITA-- 418

  Fly   339 LAMLLSPTLQMSHRLMVALLCHCNNLFADVQLIKYVPPL-TSTSPKLP----DTPEDIQTELRKQ 398
                             |:....|:.|......:|:... ||:.|...    :..||....|...
plant   419 -----------------AITIRLNSHFLQQSPARYLDKKNTSSGPATENLTLNQKEDYNQRLNVG 466

  Fly   399 DSLLSQIH------------------SEMNAG----------------FITKKR----EEQLWEV 425
            |.:|:.:.                  :.:|.|                .|:|.|    :.::||
plant   467 DDVLTILREIPGNNTCAECNAPDPDWASLNLGVLMCIECSGVHRNLGVHISKVRSLTLDVKVWE- 530

  Fly   426 QRIITQLKRKLRT--FEKKQEKTAEEVDNSSSAPPAVASEDTTDSKPAGTPAVSTNNSISQEEPK 488
             ..|..|.|.|..  .....|:....:|:.|                              |:..
plant   531 -PTILDLFRNLGNGYCNSVWEELLHHLDDDS------------------------------EKGS 564

  Fly   489 TDTLTPKDAPNDFTIDPSTGFILLPKSNPHRENLLRLQIEYDELMEWQNELKARI---VAERN-- 548
            ||||.....|:      |..:..|.:...:.:.|.:..:..|| .|..:...:||   |..||
plant   565 TDTLASVSKPS------SEDWFTLKEKYINGKYLEKALVVKDE-REANSTASSRIWEAVQSRNIR 622

  Fly   549 EVYRLKQLYEQQSINSQMASLASGSQAPPESDYERIIEHYTRENALLEHKKNMLGMELKEERRAC 613
            ::|||....:...||::...:         :|.:  :.|:...:|..|.||       :.:..||
plant   623 DIYRLIVKADANIINTKFDDI---------TDLD--VYHHHHVDAPDEVKK-------RHDPNAC 669

Fly 614 613
plant 670 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	34/196 (17%)
AGD2	NP_176283.1	BAR_SFC_plant	15..216	CDD:153290	30/131 (23%)
		PH	291..420	CDD:278594	34/193 (18%)
		PH_ACAP	293..425	CDD:270070	34/196 (17%)
		ArfGap	470..604	CDD:214518	26/172 (15%)
		ANK repeat	676..714	CDD:293786
		ANK	<684..763	CDD:238125
		Ank_4	686..737	CDD:290365
		ANK repeat	716..747	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910