Protein Alignment Rlip and Ralbp1

DIOPT Version :10

• Sequence 1: NP_650933.2
• Gene: Rlip / 42484
• FlyBaseID: FBgn0026056
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_114456.2
• Gene: Ralbp1 / 84014
• RGDID: 621134
• Length: 647
• Species: Rattus norvegicus
• Alignment Length: 648
• Identity: 221/648 - (34%)
• Similarity: 336/648 - (51%)
• Gaps: 110/648 - (16%)

  Fly     5 SPEE---KEFPGLYASEAADAKSRKSKEESDF--SEDHDHSKKDLLIGRRKDKKEKGKDRGYAAL 64
            |.||   .:|||||.:...........|..|.  .::.||.||     :.|.||::.:..||||.
  Rat    29 SSEEISPTKFPGLYRTGEPSPPHDILHEPPDIVSDDEKDHGKK-----KGKFKKKEKRTEGYAAF 88

  Fly    65 EGESSPEEELDTKSPSKSKKSK---TFKFTS-SKSKEKREKSRDKSEKDSKHAEEEPSVSHKVKE 125
            :.:||.:|   .:||||.|:||   .||..| ||.|||..|.::| .|:.||.||
  Rat    89 QEDSSGDE---AESPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEK-PKEEKHKEE---------- 139

  Fly   126 KERDKEKDRDEPKKKDKEEKRKEKDKK----AD-KKDKKDKKSKQLSQQQDDVSAAEEVLALGYP 185
                          |.||||.|||..|    || .|..|:||.|:...|:.:|...:....  .|
  Rat   140 --------------KHKEEKHKEKKCKDLTAADVVKQWKEKKKKKKPTQEPEVPQTDAPSL--RP 188

  Fly   186 VFGVSVSLATERSRCHDGVDIPLVVRDCIDFLQDH-LKCEQIYKIEPIKTRLMHFKRLYNNREHD 249
            :||..::.|.||:..:||:.:|.|.|:|:|:::.| :|||.||::..||:::...|..| :||..
  Rat   189 IFGAPLADAVERTMMYDGIRLPAVFRECVDYMEKHGMKCEGIYRVSGIKSKVDELKAAY-DREES 252

  Fly   250 SAVDELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAELQQLLEQLPKCNRTL 314
            ..::|....|..||||.:||:|||.|||.:|:.||||.........:..|.|:||.:||:.|..|
  Rat   253 PNLEEYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTEVEKVQEFQRLLRELPEYNHLL 317

  Fly   315 LAWVLLHFDAVIQQERHNKLNAQSLAMLLSPTLQMSHRLMVALLCHCNNLFADVQLIKYVPPL-- 377
            |:|:::|.|.||.:|...|:|.|:::::||||:|:|:|::..|..|...||..|.|.:...||
  Rat   318 LSWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVLFTHVQELFGTVVLKQVTRPLRW 382

  Fly   378 --TSTSPKLPDTPEDIQTELRKQDSLLSQIHSEMNAGFITKKREEQLWEVQRIITQLKRKLRTFE 440
              .:|.|.||:|...|:.|:|:|:.||:.:|.::..|.....:||:|||||||:|.||||||. .
  Rat   383 SNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLRE-A 446

  Fly   441 KKQE---KTAEEVDNSSSAPPAVASEDTTDSKPAGTPAVSTNNSISQEEPKTDTLTPKDAPNDFT 502
            |:||   |.|:|:       .:::.||                 :|:||..         .|:..
  Rat   447 KRQECETKIAQEI-------ASLSKED-----------------VSKEETN---------ENEEV 478

  Fly   503 IDPSTGFILLPKSNPHRENLLRLQIEYDELMEWQNELKARIVAERNEVYRLK----QLYEQQSIN 563
            |:     |||.:.|       .:..|.:||:..:..|:.:|.:|:.|:.||:    ::..:|...
  Rat   479 IN-----ILLAQEN-------EILTEQEELLAMEQFLRRQIASEKEEIDRLRAEIAEIQSRQHGR 531

  Fly   564 SQMASLASGSQAPPESDYER--IIEHYTRENALLEHKKNMLGMELKEERRACIALQVELRLQQ 624
            |:....:|.|::..|.:.|.  |:|...|:|..||.|.|.|...:.|||.|.:.|:|:|||.|
  Rat   532 SETEEYSSDSESESEDEEELQIILEDLQRQNEELEIKNNHLNQAVHEEREAIVELRVQLRLLQ 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	72/181 (40%)
Ralbp1	NP_114456.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..151		54/154 (35%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9PT60	102..119		7/16 (44%)
		Mediates association with membranes and could form transmembrane domains. /evidence=ECO:0000250|UniProtKB:Q15311	154..219		21/66 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..186		6/22 (27%)
		RhoGap_RalBP1	190..371	CDD:239846	72/181 (40%)
		Mediates interaction with RALA and RALB. /evidence=ECO:0000250|UniProtKB:Q15311	403..499		42/141 (30%)
		Smc	<413..>594	CDD:440809	68/226 (30%)
		Mediates interaction with REPS1 and REPS2. /evidence=ECO:0000269|PubMed:9395447, ECO:0000269|PubMed:9422736	500..647		31/95 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..550		5/24 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..647