DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rlip and Ralbp1

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001380593.1	Gene:	Ralbp1 / 84014	RGDID:	621134	Length:	647	Species:	Rattus norvegicus

Alignment Length:	648	Identity:	221/648 - (34%)
Similarity:	336/648 - (51%)	Gaps:	110/648 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SPEE---KEFPGLYASEAADAKSRKSKEESDF--SEDHDHSKKDLLIGRRKDKKEKGKDRGYAAL 64
            |.||   .:|||||.:...........|..|.  .::.||.||     :.|.||::.:..||||.
  Rat    29 SSEEISPTKFPGLYRTGEPSPPHDILHEPPDIVSDDEKDHGKK-----KGKFKKKEKRTEGYAAF 88

  Fly    65 EGESSPEEELDTKSPSKSKKSK---TFKFTS-SKSKEKREKSRDKSEKDSKHAEEEPSVSHKVKE 125
            :.:||.:|   .:||||.|:||   .||..| ||.|||..|.::| .|:.||.||
  Rat    89 QEDSSGDE---AESPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEK-PKEEKHKEE---------- 139

  Fly   126 KERDKEKDRDEPKKKDKEEKRKEKDKK----AD-KKDKKDKKSKQLSQQQDDVSAAEEVLALGYP 185
                          |.||||.|||..|    || .|..|:||.|:...|:.:|...:....  .|
  Rat   140 --------------KHKEEKHKEKKCKDLTAADVVKQWKEKKKKKKPTQEPEVPQTDAPSL--RP 188

  Fly   186 VFGVSVSLATERSRCHDGVDIPLVVRDCIDFLQDH-LKCEQIYKIEPIKTRLMHFKRLYNNREHD 249
            :||..::.|.||:..:||:.:|.|.|:|:|:::.| :|||.||::..||:::...|..| :||..
  Rat   189 IFGAPLADAVERTMMYDGIRLPAVFRECVDYMEKHGMKCEGIYRVSGIKSKVDELKAAY-DREES 252

  Fly   250 SAVDELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAELQQLLEQLPKCNRTL 314
            ..::|....|..||||.:||:|||.|||.:|:.||||.........:..|.|:||.:||:.|..|
  Rat   253 PNLEEYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTEVEKVQEFQRLLRELPEYNHLL 317

  Fly   315 LAWVLLHFDAVIQQERHNKLNAQSLAMLLSPTLQMSHRLMVALLCHCNNLFADVQLIKYVPPL-- 377
            |:|:::|.|.||.:|...|:|.|:::::||||:|:|:|::..|..|...||..|.|.:...||
  Rat   318 LSWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVLFTHVQELFGTVVLKQVTRPLRW 382

  Fly   378 --TSTSPKLPDTPEDIQTELRKQDSLLSQIHSEMNAGFITKKREEQLWEVQRIITQLKRKLRTFE 440
              .:|.|.||:|...|:.|:|:|:.||:.:|.::..|.....:||:|||||||:|.||||||. .
  Rat   383 SNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLRE-A 446

  Fly   441 KKQE---KTAEEVDNSSSAPPAVASEDTTDSKPAGTPAVSTNNSISQEEPKTDTLTPKDAPNDFT 502
            |:||   |.|:|:       .:::.||                 :|:||..         .|:..
  Rat   447 KRQECETKIAQEI-------ASLSKED-----------------VSKEETN---------ENEEV 478

  Fly   503 IDPSTGFILLPKSNPHRENLLRLQIEYDELMEWQNELKARIVAERNEVYRLK----QLYEQQSIN 563
            |:     |||.:.|       .:..|.:||:..:..|:.:|.:|:.|:.||:    ::..:|...
  Rat   479 IN-----ILLAQEN-------EILTEQEELLAMEQFLRRQIASEKEEIDRLRAEIAEIQSRQHGR 531

  Fly   564 SQMASLASGSQAPPESDYER--IIEHYTRENALLEHKKNMLGMELKEERRACIALQVELRLQQ 624
            |:....:|.|::..|.:.|.  |:|...|:|..||.|.|.|...:.|||.|.:.|:|:|||.|
  Rat   532 SETEEYSSDSESESEDEEELQIILEDLQRQNEELEIKNNHLNQAVHEEREAIVELRVQLRLLQ 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	72/181 (40%)
Ralbp1	NP_001380593.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..151		54/154 (35%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9PT60	102..119		7/16 (44%)
		Mediates association with membranes and could form transmembrane domains. /evidence=ECO:0000250\|UniProtKB:Q15311	154..219		21/66 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..186		6/22 (27%)
		RhoGap_RalBP1	190..371	CDD:239846	72/181 (40%)
		SMC_prok_B	<395..>594	CDD:274008	74/244 (30%)
		Mediates interaction with RALA and RALB. /evidence=ECO:0000250\|UniProtKB:Q15311	403..499		42/141 (30%)
		Mediates interaction with REPS1 and REPS2. /evidence=ECO:0000269\|PubMed:9395447, ECO:0000269\|PubMed:9422736	500..647		31/95 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..550		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..647
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340567
Domainoid	1	1.000	120	1.000	Domainoid score	I5612
eggNOG	1	0.900	-	-		E1_KOG4370
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2737
OMA	1	1.010	-	-		QHG49463
OrthoDB	1	1.010	-	-		D514124at2759
OrthoFinder	1	1.000	-	-		FOG0005056
OrthoInspector	1	1.000	-	-		otm45814
orthoMCL	1	0.900	-	-		OOG6_107500
Panther	1	1.100	-	-	LDO	PTHR12783
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.810