DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rlip and Gmip

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_030099716.1	Gene:	Gmip / 78816	MGIID:	1926066	Length:	1002	Species:	Mus musculus

Alignment Length:	435	Identity:	95/435 - (21%)
Similarity:	157/435 - (36%)	Gaps:	119/435 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 DIPLVVRDCIDFLQDH-LKCEQIYKIEPIKTRLMHFKRLYNNREHDSAVDEL--NLP-TACSLLK 265
            ::|.|:..|...::.. |..:.||::...:.|:   :||....|:..|:.||  |.| ...|:||
Mouse   574 EVPFVITRCTAEIEHRALGLQGIYRVSGSRVRV---ERLCQAFENGRALVELSGNSPHDITSVLK 635

  Fly   266 LFLRELPEPLLTTDLVARFEEVA--------SHPKVTTQQAE----LQQLLEQLPKCNRTLLAWV 318
            .||:||.:|::...|...|..:|        ..|.......|    |:.||.|||..|.:.|..:
Mouse   636 RFLQELTDPVVPFHLYDAFISLAKTLHADPGDDPGTPNPSPEIIRSLKTLLVQLPDSNYSTLRHL 700

  Fly   319 LLHFDAVIQQERHNKLNAQSLAMLLSPT-------------------LQMSH--RLMVALLCHCN 362
            :.|...|..:...||::|.:|.::..||                   |...|  :|:..|:.|..
Mouse   701 VAHLFRVAARFEENKMSANNLGIVFGPTLLRPPDGPRATGASPVACLLDSGHQAQLVEFLIVHYE 765

  Fly   363 NLFADVQLIKYVPPLTSTSPKLPDTPEDIQTELRKQDSLLSQ----------------IHSEMNA 411
            .:|...:|.....|||. .|.|  .|..:::..:...|||:|                .||.:
Mouse   766 QIFGMDELPLASEPLTQ-DPGL--APACLESSPQHPASLLAQDTQPLTIALDSSPDPKHHSAL-- 825

  Fly   412 GFITKKREEQLWEVQRIITQLKR-------------KLRTFEKKQEKTAEEV--------DNSSS 455
                    |:..||......|.|             :|.|.::.|.:  |||        |.||.
Mouse   826 --------EKCPEVTPPEKSLNRDFAIGSHVLGFFLQLATLQRDQRE--EEVEDTRDGAGDGSSH 880

  Fly   456 APPAVA---------SEDTTDSKPAGTPAVS--------TNNSISQEEPKTDTLTPKDAPNDFTI 503
            .|..:|         |.........|...|:        ..:.:.:|.|.|.:...:.:.....:
Mouse   881 CPEDLALGAQSRGHFSRQPVKYSRGGVRPVTHQLSSLALVASKLCEETPVTVSAVHRGSLRVRGL 945

  Fly   504 DPSTGFILLPKSNPHRENLLRLQIEYDELMEWQNELKARIVAERN 548
            .|:..   .|:.:|.|.|.|....|.       .:..||::::.|
Mouse   946 GPAAA---CPEGSPLRRNPLPKHFEI-------TQETARLLSKLN 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	50/199 (25%)
Gmip	XP_030099716.1	BAR	124..324	CDD:386243
		C1	503..548	CDD:197519
		RhoGAP	560..763	CDD:383032	48/191 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910