DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rlip and Appl1

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_660256.1	Gene:	Appl1 / 72993	MGIID:	1920243	Length:	707	Species:	Mus musculus

Alignment Length:	441	Identity:	85/441 - (19%)
Similarity:	151/441 - (34%)	Gaps:	145/441 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 KKSKQLSQQQDDVSAAEEVLALGYPVFGVSVSLATERSRCH--------DGVDIPL---VVRDCI 214
            |..|:..:|:..:...:||::.....|.   .:..|.|.||        |.:..|:   ..||
Mouse    63 KLLKEYEKQRFPLGGDDEVMSSTLQQFS---KVIDELSSCHAVLSTQLADAMMFPISQFKERD-- 122

  Fly   215 DFLQDHLKCEQIYKI--EPIKTRLMHFKRLYNNREHDSAVDELN--------------LPTACSL 263
              |::.|..:::::|  ......:..:.||...||:|....|:.              :...|:|
Mouse   123 --LKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCAL 185

  Fly   264 LKLFLRE---LPEPLL-------------TTDLVARFEEVASHPKVTTQQAE---------LQQL 303
            ..|..::   |.||||             :.:|..:.||..::...:.|...         :||.
Mouse   186 NTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNGQLEEFLANIGTSVQNVRREMDGDVETMQQT 250

  Fly   304 LEQLP----------------KCNRTLLAWVLLHFDAVIQQERHNKLNAQSLAMLLSPT------ 346
            :|.|.                ..||.|             ..:...|||::...|:|.|
Mouse   251 IEDLEVASDPLYLPDPDPTKFPINRNL-------------TRKAGYLNARNKTGLVSSTWDRQFY 302

  Fly   347 LQMSHRLM----------VAL-LCHCNNLFADVQLIKYVPPLTSTSPKLPDTPEDIQTELRKQDS 400
            ......||          :|: :.:|:.:..|.:..:|...:||..              .|:.|
Mouse   303 FTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFD--------------GKKSS 353

  Fly   401 LLSQIHSEMNAGFITKKREEQLWEVQRIITQLKRKLRTFEKKQEKTAEEVDNSS--SAPPAVASE 463
            :| |..|:       |..||.:..:..|..|:     ...:..|:||..|:.|:  :..|:.:.:
Mouse   354 IL-QAESK-------KDHEEWICTINNISKQI-----YLSENPEETAARVNQSALEAVTPSPSFQ 405

  Fly   464 DTTDS-KPAG-----TPAVSTNNSISQEEP-----KTDTLTPKDAPNDFTI 503
            ...:| :|.|     |...|::.|:..|..     ..|:|...|.|..|.|
Mouse   406 QRHESLRPGGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDI 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	47/265 (18%)
Appl1	NP_660256.1	Required for RAB5A binding. /evidence=ECO:0000250	1..428		77/411 (19%)
		BAR_APPL1	20..234	CDD:153315	34/177 (19%)
		BAR-PH_APPL	252..376	CDD:270067	28/158 (18%)
		PH	280..375	CDD:278594	23/116 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..433		7/35 (20%)
		F&H. /evidence=ECO:0000250	403..414		1/10 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..490
		PTB_APPL	489..624	CDD:269980
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..707
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910