DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rlip and BCR

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_004318.3	Gene:	BCR / 613	HGNCID:	1014	Length:	1271	Species:	Homo sapiens

Alignment Length:	425	Identity:	91/425 - (21%)
Similarity:	158/425 - (37%)	Gaps:	126/425 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KKDLLIGRRKDKKEKGKDRGYAALEGESSPEEE-LDTKSPS-----KSKKSKTFKFTSSKSKEK- 98
            |.|:...:|.:|..|..:|    |:.:.|.:|. |...|||     .|:..|::.|..|...|:
Human   795 KNDIQREKRANKGSKATER----LKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERA 855

  Fly    99 --REKSRDKSEK-------------------------------DSKHAEEEP------------- 117
              ||..|::.:|                               .:|..:|.|
Human   856 EWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSA 920

  Fly   118 ----------------SVSHKVKEKERDKEKDRDEPKKKDKEEKR-----------KEKDKKADK 155
                            |..:.|.:.:....:|..||...::.|..           .||.....|
Human   921 TGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTK 985

  Fly   156 KDKKDKKSKQ----LSQQQDDVSAAEE------VLALG-------------------YP------ 185
            ..|:|.:|..    ..|.|.|..|.::      |:|:.                   .|
Human   986 IPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTG 1050

  Fly   186 VFGVSVSLATERSRCHDGVDIPLVVRDCIDFLQDH-LKCEQIYKIEPIKTRLMHFKRLY--NNRE 247
            ||||.:::.|:|.|.    .:|.:||.|::.::.. ::...||::..:.|.:...|..:  ||::
Human  1051 VFGVKIAVVTKRERS----KVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKD 1111

  Fly   248 HDSAVDELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAELQQLLEQLPKCNR 312
            ....:.|:::......|||:.|||||||.|.:....|.|..:......:::.:..||..||:.|.
Human  1112 VSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANL 1176

  Fly   313 TLLAWVLLHFDAVIQQERHNKLNAQSLAMLLSPTL 347
            ....::|.|...|.::|..||::..:||.:..|||
Human  1177 LTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTL 1211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	46/164 (28%)
BCR	NP_004318.3	Kinase	1..426
		Bcr-Abl_Oligo	3..75	CDD:286168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..173
		BAT2_N	<81..174	CDD:284431
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..247
		Binding to ABL SH2-domain	197..385
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..392
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..476
		RhoGEF	502..690	CDD:279015
		PH_BCR_vertebrate	684..877	CDD:270173	22/85 (26%)
		C2_ABR	913..1033	CDD:176068	18/119 (15%)
		RhoGAP_Bcr	1052..1252	CDD:239852	46/164 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910