DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rlip and arhgap35b

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_003198691.2	Gene:	arhgap35b / 564565	ZFINID:	ZDB-GENE-060526-44	Length:	1517	Species:	Danio rerio

Alignment Length:	372	Identity:	86/372 - (23%)
Similarity:	155/372 - (41%)	Gaps:	77/372 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDSPEEKEFPGLYASEAADA--KSRKSKEESDFSEDHDHSKKDLLIGRRKDKKEKGKDRGYAAL 64
            |:|       |..|| |..||  |.|.|.|:|.:|..||.::..::..|..::.........:..
Zfish  1099 DYD-------PSDYA-EPMDAVSKPRPSYEDSIYSVPHDSTQGKIITIRNSNRIHSNGGGNGSDS 1155

  Fly    65 EGESSPEEELDTKSPSKSKKSKTFKFTSSKSKEKREKSRDKSEKDSKHAEEEPSVS----HKVKE 125
            ||:.|..|             :..||::::.|.:  ..||:|::..|.:....|.|    .::..
Zfish  1156 EGDGSSLE-------------RRRKFSAARVKPR--LYRDRSKRLGKFSSFRTSFSIGSDDEIGT 1205

  Fly   126 KERDKEKD------------RDEPKKKDKEEKRKEKDKKADKKDKKDKKSKQLSQQQDDVSAAEE 178
            ..|.||.|            .::|||::..:..:...|||..|.:            ..:|...|
Zfish  1206 LSRSKEDDVSPLKTDITNEEGEDPKKRNILKSLRRPGKKARPKPR------------HSISKPLE 1258

  Fly   179 VLALGYPVFGVSVSLATERSRCHDGVDIPLVVRDCIDFLQ-DHLKCEQIYKIEPIKTRLMHFKRL 242
            ....|.|:..|   ::.||       .||:.:..||.::: ..|..|.||::...|..:...:|.
Zfish  1259 SNYFGVPLVNV---VSFER-------PIPVFIDKCIRYIEATGLTTEGIYRVSGNKAEIEGMQRQ 1313

  Fly   243 YNNREHDSAVD----ELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAEL--- 300
            :   |.|..:|    :..:.|....:|.|..|||:||:.   .:..||:....|:..::..|
Zfish  1314 F---EQDHNLDFVEKDFTVNTVAGAMKSFFSELPDPLVP---YSSQEELVEAFKINDREQRLHTM 1372

  Fly   301 QQLLEQLPKCNRTLLAWVLLHFDAVIQQERHNKLNAQSLAMLLSPTL 347
            :.:|.:.|:.|..:..:|:.|.:.|.|..|.|.:.:::|::...|||
Zfish  1373 KDVLRRFPRENFDVFKYVMSHLNKVGQWNRVNLMTSENLSICFWPTL 1419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	41/169 (24%)
arhgap35b	XP_003198691.2	Ras_like_GTPase	29..245	CDD:206648
		Ras	<158..247	CDD:331851
		RhoGAP-FF1	261..340	CDD:318668
		FF	431..483	CDD:128718
		RhoGAP_p190	1262..1446	CDD:239838	43/174 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910