DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rlip and arhgap12a

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_021336423.1	Gene:	arhgap12a / 563267	ZFINID:	ZDB-GENE-050809-38	Length:	853	Species:	Danio rerio

Alignment Length:	382	Identity:	95/382 - (24%)
Similarity:	156/382 - (40%)	Gaps:	62/382 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DHSKK--------------DLLIGRRKDKKEKGKDRGYAALEGESSPEEELDTKSPSKSKKSKTF 88
            :|.||              .|||    ..|.:|...|:...:.:||.|..:|.|..|....||.
Zfish   482 EHGKKVRKNWTSYWTVLQGSLLI----FNKGQGGGSGWFGRDQKSSVEYSVDLKGGSVDWASKD- 541

  Fly    89 KFTSSKSKEKREKSRDKSE----KDSKHAEEEPSVSHKVKEK-------ERDKEKDRDEPKKKDK 142
              .|||......|:|..:|    .||.....:   .||...:       |.|:..:.|.|:..:.
Zfish   542 --KSSKKHVLELKTRQGTELLLQSDSDGLVND---WHKALTEAIHTYMWESDEAIEEDMPESPEN 601

  Fly   143 EEKRKEKDKKADKKDKKDKKSKQLSQQQDDVSAAEEVLALGYP--------------VFGVSVSL 193
            |:..||||:|..||.:..||:..:...:........||.||.|              |||.|:|.
Zfish   602 EKHDKEKDRKNSKKARDIKKTASMDNAEQKKKNKLVVLLLGRPTLQAVKDKGYIKDQVFGCSLSS 666

  Fly   194 ATERSRCHDGVDIPLVVRDCIDFLQDH-LKCEQIYKIEPIKTRLMHFKRLYNNREH----DSAVD 253
            ..:|    :...:|..|..||:.::.: |..:.:|::......:...:...|:.|.    ||..:
Zfish   667 LCQR----ENSTVPRFVWLCIEQVEKNGLGVDGLYRVSGNLAIIQKLRFAVNHEEKIDLGDSKWE 727

  Fly   254 ELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAELQQLLEQLPKCNRTLLAWV 318
            ::::.|..  ||:|.|||||||.|....:.|......|....:...::.|:::||:.|...:..:
Zfish   728 DIHVTTGA--LKMFFRELPEPLFTYTFFSDFISAIKMPDYKQKVQTVKDLMKKLPRPNHDTIQVL 790

  Fly   319 LLHFDAVIQQERHNKLNAQSLAMLLSPTLQMSHRLMVALLCHC--NNLFADVQLIKY 373
            ..|...|||....|::..||:|::..|||.........:..|.  .|...::.|::|
Zfish   791 FKHLKKVIQHVDENRMTTQSVAIVFGPTLLRPEIETANMAVHMVYQNQIVELILMEY 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	46/187 (25%)
arhgap12a	XP_021336423.1	SH3_ARHGAP12	11..70	CDD:213003
		SH3-WW_linker	67..233	CDD:318759
		WW	252..278	CDD:306827
		PH_ARHGAP9-like	470..580	CDD:270053	27/107 (25%)
		RhoGAP_ARHGAP27_15_12_9	660..846	CDD:239868	47/191 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910