DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rlip and Arhgap40

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001138487.1	Gene:	Arhgap40 / 545481	MGIID:	3649852	Length:	672	Species:	Mus musculus

Alignment Length:	394	Identity:	88/394 - (22%)
Similarity:	147/394 - (37%)	Gaps:	98/394 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 VFGVSV-SLATERSRCHDGVDIPLVVRDCIDFLQDH-LKCEQIYKIEPIKTRLMHFKRLYNNREH 248
            :|||.: ||.....|......:||:::..:..|:.. |..|.|.::...:.|:   |.|....|.
Mouse   318 LFGVPLHSLLEADHRVFPSTQVPLLLQALLSCLEKRGLDTEGILRVPGSQARV---KGLEQKLER 379

  Fly   249 D-----SAVDELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVASHPKVTTQQAELQQLLEQLP 308
            |     .:.|:::...|..|||.|||:||.||||.:.:..|..|...|.:..:...|..|:..||
Mouse   380 DFYAGLVSWDKVHPNDASDLLKRFLRKLPVPLLTAEYLPAFASVPDIPDLKQRLQALHLLVLLLP 444

  Fly   309 KCNRTLLAWVLLHFDAVIQQERHNKLNAQSLAMLLSPTLQMSHRLMVALLCHCNNLFADVQLIKY 373
            :.||..|..:|.....|..||:|||:...:::.::.|:|                         :
Mouse   445 EPNRNTLKALLEFLRKVAAQEQHNKMTLWNVSTVMVPSL-------------------------F 484

  Fly   374 VPPLTSTSPKLPDTPEDIQTELRKQDSLLSQIHSEMNAGFITKKREEQLWEVQRIITQLKRKLRT 438
            :|  ....|||        |:..||   |::..:|:....:  :.::.||.|...:....|||..
Mouse   485 LP--RGRPPKL--------TKGGKQ---LAEGAAEVVCMMV--QYQDLLWTVASFLVAQVRKLND 534

  Fly   439 FEKKQEKTAE----------EVDNSSS-----APPAVA---------SED--------------- 464
            ...::.:..:          .||...:     |.|.||         |.|
Mouse   535 SNGRRSQLCDGGLKTWLWRTHVDRDKAGEGLEATPKVAKIQVQATWPSMDLLQVPLNPSTRVTHV 599

  Fly   465 ----TTDSKPAGTPAVSTN--NSISQEEPKTDTLTPKDAPNDF---TIDPSTGFILLPKSNPHRE 520
                |....|...|...:.  ||:.....|..|....:...:.   .:||....:.|.::|||.|
Mouse   600 LKLFTEHLNPGSQPEEGSENPNSLLSHNTKPVTFLVYEVGGNIGERRLDPDAYLLDLYRANPHGE 664

  Fly   521 NLLR 524
            .::|
Mouse   665 WVIR 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	50/187 (27%)
Arhgap40	NP_001138487.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..68
Arhgap40	NP_001138487.1	RhoGAP	318..530	CDD:295372	62/254 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1372
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000