DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rlip and OPHN1

DIOPT Version :9

Sequence 1:	NP_650933.2	Gene:	Rlip / 42484	FlyBaseID:	FBgn0026056	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_002538.1	Gene:	OPHN1 / 4983	HGNCID:	8148	Length:	802	Species:	Homo sapiens

Alignment Length:	612	Identity:	112/612 - (18%)
Similarity:	206/612 - (33%)	Gaps:	185/612 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 HSKKDLLI--------------GRRKDKKEKGKDRGYAALEGESSPEEELDTKSPSKSKKSKTFK 89
            |:..||||              ..||.|.||..:|.|:.|:                     ...
Human   106 HNASDLLIKPLENFRKEQIGFTKERKKKFEKDGERFYSLLD---------------------RHL 149

  Fly    90 FTSSKSKEKREKSRDKSEKDSKHAEEEPSVS--HKVKEKERDKEKDRDEP--------------- 137
            ..|||.||.:.:..|......:|...|.|:.  ::::|.:..|:.:..||
Human   150 HLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLT 214

  Fly   138 --------------------------KKKDKEEKRKEKDKKADKKDK------------------ 158
                                      ..:::.|:.|::.|:|.:..|
Human   215 VELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWA 279

  Fly   159 -----------KDKKSKQLS----QQQDDVSAAEEVLALGYPV------------FGV------- 189
                       .:|::|.|:    :|:.........|.|.|.|            |.:
Human   280 LGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPG 344

  Fly   190 -----SVSLATER--SRCHDGVDIPL-------------------VVRDCIDFLQDH-LKCEQIY 227
                 ::|.|..|  ....||.: |:                   .||.||:.::.. :|.|.:|
Human   345 TITLQALSEANRRLWMEAMDGKE-PIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLY 408

  Fly   228 KIEPIKTRLMHFKRLYNNREHDSAVD----ELNLPTACSLLKLFLRELPEPLLTTDLVARFEEVA 288
            :......::......:.:.:....||    :.::.|..|.||.:||.|.||::|..|.......|
Human   409 RTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAA 473

  Fly   289 SHPKVTTQQAELQQLLEQLPKCNRTLLAWVLLHFDAVIQQERHNKLNAQSLAMLLSPTLQMSHRL 353
            ....:..:...:..|:.:||:.||.:|..::.|...|.:..:.|.:...::.::..|||..:...
Human   474 KSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQED 538

  Fly   354 MVALLCHC--NNLFADVQLIKYV------PPLTSTSPKLPDTPEDIQTELRKQDSLLSQIHSEMN 410
            .||.:.:.  .|:..:: ||::.      ||..|.:|.:|  |..:.....|..::..::..|..
Human   539 TVAAMMNIKFQNIVVEI-LIEHFGKIYLGPPEESAAPPVP--PPRVTARRHKPITISKRLLRERT 600

  Fly   411 AGFITKKREEQLWEVQR------IITQLK-RKLRTFEKKQEKTAEEVDNSSSAPPAVASEDTTDS 468
            . |.|...:|...|:|.      |.:.:: .|.....|...:.:.|.|....:|    |....|.
Human   601 V-FYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSP----SRPILDG 660

  Fly   469 KPAGTPAVSTNNSISQEEPKTDTLTPK 495
            |....|.|.....:|:.:.....:|||
Human   661 KLEPCPEVDVGKLVSRLQDGGTKITPK 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rlip	NP_650933.2	RhoGap_RalBP1	187..368	CDD:239846	43/220 (20%)
OPHN1	NP_002538.1	BAR_OPHN1	19..225	CDD:153317	26/139 (19%)
		PH	266..363	CDD:278594	12/96 (13%)
		BAR-PH_GRAF_family	267..370	CDD:269953	15/103 (15%)
		RhoGAP_Graf	363..559	CDD:239839	41/197 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	569..588		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..666		12/62 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..770		3/8 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	783..802
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910